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TAOK2 Antibody (PA5-29249) in ICC/IF
TAOK2 Polyclonal Antibody detects TAOK2 protein at cytoplasm and nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: TAOK2 protein stained by TAOK2 Polyclonal Antibody (Product # PA5-29249) diluted at 1:500. Blue: Hoechst 33343 staining.
Product Details
PA5-29249
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 69 and 350 of Human TAOK2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546725
Product Specific Information
Recommended positive controls: mouse brain.
Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (93%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TAOK2 (TAO1) is a serine/threonine kinase that may be an important regulator of the stress-responsive p38 MAP kinase pathway. In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEK ) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonist to the stress -responsive p38 MAPK (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hKFC-C; Kinase from chicken homolog C; prostate derived STE20-like kinase PSK; prostate-derived STE20-like kinase 1; Prostate-derived sterile 20-like kinase 1; PSK-1; Serine/threonine-protein kinase TAO2; tao; TAO kinase 2TAO kinase 2; Thousand and one amino acid protein 2; Thousand and one amino acid protein kinase 2
Gene Aliases: 1110033K02Rik; B230344N16; KIAA0881; MAP3K17; mKIAA0881; PSK; PSK1; PSK1-BETA; TAO1; TAO2; TAOK2; UNQ2971/PRO7431
UniProt ID: (Human) Q9UL54, (Mouse) Q6ZQ29
Entrez Gene ID: (Human) 9344, (Mouse) 381921
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
mitogen-activated protein kinase kinase binding
nucleotide binding
protein kinase activity
MAP kinase kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPKK activity
regulation of cell growth
protein targeting to membrane
apoptotic process
response to stress
cellular response to DNA damage stimulus
regulation of cell shape
cell migration
actin cytoskeleton organization
G2 DNA damage checkpoint
positive regulation of stress-activated MAPK cascade
positive regulation of JNK cascade
focal adhesion assembly
stress-activated MAPK cascade
MAPK cascade
protein phosphorylation
regulation of mitotic cell cycle
phosphorylation
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
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