Proteintech

TBCA Polyclonal Antibody

TBCA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TBCA Antibody (12304-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer using 12304-1-AP (TBCA antibody) at dilution of 1:50 (under 10x lens).

TBCA Antibody in Immunoprecipitation (IP)

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Product Details

12304-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1500

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TBCA Fusion Protein Ag2950 (1-108 aa encoded by BC018210)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MADPRVRQI KIKTGVVKRL VKEKVMYEKE AKQQEEKIEK MRAEDGENYD IKKQAEILQE SRMMIPDCQR RLEAAYLDLQ RILENEKDLE EAEEYKEARL VLDSVKLEA (1-108 aa encoded by BC018210 )

Target Information

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Target-Sequencing of Female Infertility Pathogenic Gene Panel and a Novel TUBB8 Loss-of-Function Mutation.

Frontiers in genetics

Yuan H,Chen J,Li N,Miao H,Chen Y,Lyu S,Qiao Y,Yang G,Luo H,Chen L,Mao F,Huang L,He Y,Hu S,Miao C,Qian Y,Feng R

Sat Jul 16 00:00:00 EDT 2022

Spatio-temporal distribution of tubulin-binding cofactors and posttranslational modifications of tubulin in the cochlea of mice.

Histochemistry and cell biology

Juergens L,Bieniussa L,Voelker J,Hagen R,Rak K

Tue Dec 01 00:00:00 EST 2020

ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer.

Oncology reports

Guo L,Ma L,Liu C,Lei Y,Tang N,Huang Y,Huang G,Li D,Wang Q,Liu G,Tang M,Jing Z,Deng Y

Fri Mar 01 00:00:00 EST 2019

Tubulin cofactor A functions as a novel positive regulator of ccRCC progression, invasion and metastasis.

International journal of cancer

Zhang P,Ma X,Song E,Chen W,Pang H,Ni D,Gao Y,Fan Y,Ding Q,Zhang Y,Zhang X

Sun Dec 15 00:00:00 EST 2013

Tubulin cofactor A functions as a novel positive regulator of ccRCC progression, invasion and metastasis.

International journal of cancer

Zhang P,Ma X,Song E,Chen W,Pang H,Ni D,Gao Y,Fan Y,Ding Q,Zhang Y,Zhang X

Sun Dec 15 00:00:00 EST 2013

Tubulin cofactor A functions as a novel positive regulator of ccRCC progression, invasion and metastasis.

International journal of cancer

Zhang P,Ma X,Song E,Chen W,Pang H,Ni D,Gao Y,Fan Y,Ding Q,Zhang Y,Zhang X

Sun Dec 15 00:00:00 EST 2013

Tubulin cofactor A functions as a novel positive regulator of ccRCC progression, invasion and metastasis.

International journal of cancer

Zhang P,Ma X,Song E,Chen W,Pang H,Ni D,Gao Y,Fan Y,Ding Q,Zhang Y,Zhang X

Sun Dec 15 00:00:00 EST 2013

Bioinformatics

Protein Aliases: CFA; chaperonin cofactor A; co-chaperonin associated with a- & b-tubulin; cofactor A; TCP1-chaperonin cofactor A; tubulin cofactor a; Tubulin-folding cofactor A; Tubulin-specific chaperone A

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Gene Aliases: TBCA; Tbca13

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UniProt ID: (Human) O75347, (Mouse) P48428, (Rat) Q6PEC1

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Entrez Gene ID: (Human) 6902, (Mouse) 21371, (Rat) 366995

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Function(s)

protein binding poly(A) RNA binding beta-tubulin binding chaperone binding tubulin binding unfolded protein binding chaperonin

Process(es)

protein folding tubulin complex assembly post-chaperonin tubulin folding pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TBCA Polyclonal Antibody

TBCA Antibody (12304-1-AP) in IHC (P)

Product Details

12304-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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