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Product Details
H00006926-M02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
8H3
Immunogen
TBX3 (NP_005987, 311 a.a. approximately 410 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: KENGTSDESS SEQAAFNCFA QASSPAASTV GTSNLKDLCP SEGESDAEAE SKEEHGPEAC DAAKISTTTS EEPCRDKGSP AVKAHLFAAE RPRDSGRLDK
Target Information
T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bladder cancer related protein XHL; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3
Gene Aliases: D5Ertd189e; TBX3; TBX3-ISO; UMS; XHL
UniProt ID: (Human) O15119, (Mouse) P70324, (Rat) Q7TST9
Entrez Gene ID: (Human) 6926, (Mouse) 21386, (Rat) 353305
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
RNA polymerase II activating transcription factor binding
protein binding
sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
molecular_function
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
blood vessel development
in utero embryonic development
heart looping
outflow tract morphogenesis
atrioventricular bundle cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell aging
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
organ morphogenesis
specification of organ position
stem cell population maintenance
limbic system development
male genitalia development
female genitalia development
negative regulation of epithelial cell differentiation
mammary gland development
luteinizing hormone secretion
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
forelimb morphogenesis
embryonic digit morphogenesis
negative regulation of apoptotic process
negative regulation of myoblast differentiation
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
follicle-stimulating hormone secretion
mesoderm morphogenesis
palate development
ventricular septum morphogenesis
branching involved in mammary gland duct morphogenesis
mammary placode formation
cardiac muscle cell fate commitment
sinoatrial node cell development
cellular senescence
positive regulation of stem cell proliferation
heart morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
embryonic heart tube development
limb morphogenesis
regulation of cell proliferation
cardiac muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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