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TCEB1 Antibody (A304-787A) in IHC
Detection of human TCEB1 by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-TCEB1 (Cat. No. A304-787A Lot1) used at a dilution of 1:1,000 (1µg/ml). Detection: DAB. Counterstain: IHC Hematoxylin (blue).
Product Details
A304-787A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 to 50 of Human Transcription elongation factor B polypeptide 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
TCEB1 is known as protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EloC; Elongin 15 kDa subunit; elongin C; Elongin-C; RNA polymerase II transcription factor SIII subunit C; SIII p15; Stromal membrane-associated protein SMAP1B homolog; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); Transcription elongation factor B polypeptide 1
Gene Aliases: 2610043E24Rik; 2610301I15Rik; AA407206; AI987979; AW049146; ELOC; SIII; TCEB1
UniProt ID: (Human) Q15369, (Mouse) P83940
Entrez Gene ID: (Human) 6921, (Mouse) 67923
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
viral process
positive regulation of transcription elongation from RNA polymerase II promoter
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
transcription, DNA-templated
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
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