Product References
Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through control of cell heme allocation by nitric oxide.
The Journal of biological chemistry
Biswas P,Stuehr DJ
Thu Jun 01 00:00:00 EDT 2023
Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway.
Cell communication and signaling : CCS
Liang X,Du W,Huang L,Xiang L,Pan W,Yang F,Zheng F,Xie Y,Geng L,Gong S,Xu W
Fri Jun 16 00:00:00 EDT 2023
DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.
The Journal of nutritional biochemistry
Zhao LP,Wu J,Quan W,Zhou Y,Hong H,Niu GY,Huang SB,Qiao CM,Zhao WJ,Cui C,Shen YQ
Mon May 01 00:00:00 EDT 2023
Expression of Tryptophan Metabolism Enzymes in Patients with Diffuse Large B-cell Lymphoma and NK/T-cell Lymphoma.
Cancer medicine
Guo D,Wang Y,Wu X,Gao Y,Wang A,Zhang Z,Zhao K,Wang X,Liu M,Zhang Y,Li M,Chen R,Sun J,Zhang Y
Thu Jun 01 00:00:00 EDT 2023
Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.
Research square
Buyukcelebi K,Chen X,Abdula F,Duval A,Ozturk H,Seker-Polat F,Jin Q,Yin P,Feng Y,Wei JJ,Bulun S,Yue F,Adli M
Thu Feb 09 00:00:00 EST 2023
DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.
Frontiers in immunology
Zhao LP,Wu J,Quan W,Zhou Y,Hong H,Niu GY,Li T,Huang SB,Qiao CM,Zhao WJ,Cui C,Shen YQ
Tue Feb 14 00:00:00 EST 2023
Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.
Journal of medicinal chemistry
Zhang Y,Li Y,Chen X,Chen X,Chen C,Wang L,Dong X,Wang G,Gu R,Li F,Han F,Chen D
Thu Aug 25 00:00:00 EDT 2022
Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice.
International journal of tryptophan research : IJTR
Sato M,Okuno A,Ishisono K,Yajima Y,Toyoda A
Fri Nov 04 00:00:00 EDT 2022
High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis.
BMC musculoskeletal disorders
Rong G,Zhang T,Xu Y,Zhang Z,Gui B,Hu K,Zhang J,Tang Z,Shen C
Wed Jun 22 00:00:00 EDT 2022
High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis.
BMC musculoskeletal disorders
Rong G,Zhang T,Xu Y,Zhang Z,Gui B,Hu K,Zhang J,Tang Z,Shen C
Wed Jun 22 00:00:00 EDT 2022
High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis.
BMC musculoskeletal disorders
Rong G,Zhang T,Xu Y,Zhang Z,Gui B,Hu K,Zhang J,Tang Z,Shen C
Wed Jun 22 00:00:00 EDT 2022
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Nature communications
Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG
Fri Oct 14 00:00:00 EDT 2022
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Nature communications
Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG
Fri Oct 14 00:00:00 EDT 2022
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Nature communications
Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG
Fri Oct 14 00:00:00 EDT 2022
Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Nature communications
Kim YS,Ko B,Kim DJ,Tak J,Han CY,Cho JY,Kim W,Kim SG
Fri Oct 14 00:00:00 EDT 2022
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
British journal of pharmacology
Chang Y,Han P,Wang Y,Jia C,Zhang B,Zhao Y,Li S,Li S,Wang X,Yang X,Wei W
Wed Jun 01 00:00:00 EDT 2022
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
British journal of pharmacology
Chang Y,Han P,Wang Y,Jia C,Zhang B,Zhao Y,Li S,Li S,Wang X,Yang X,Wei W
Wed Jun 01 00:00:00 EDT 2022
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
British journal of pharmacology
Chang Y,Han P,Wang Y,Jia C,Zhang B,Zhao Y,Li S,Li S,Wang X,Yang X,Wei W
Wed Jun 01 00:00:00 EDT 2022
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
British journal of pharmacology
Chang Y,Han P,Wang Y,Jia C,Zhang B,Zhao Y,Li S,Li S,Wang X,Yang X,Wei W
Wed Jun 01 00:00:00 EDT 2022
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
British journal of pharmacology
Chang Y,Han P,Wang Y,Jia C,Zhang B,Zhao Y,Li S,Li S,Wang X,Yang X,Wei W
Wed Jun 01 00:00:00 EDT 2022
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
British journal of pharmacology
Chang Y,Han P,Wang Y,Jia C,Zhang B,Zhao Y,Li S,Li S,Wang X,Yang X,Wei W
Wed Jun 01 00:00:00 EDT 2022
The Immunological Contribution of a Novel Metabolism-Related Signature to the Prognosis and Anti-Tumor Immunity in Cervical Cancer.
Cancers
Yu S,Li X,Ma M,Yang R,Zhang J,Wu S
Fri May 13 00:00:00 EDT 2022
The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.
Nutrients
Mudhish EA,Siddique AB,Ebrahim HY,Abdelwahed KS,King JA,El Sayed KA
Mon Apr 04 00:00:00 EDT 2022
TDO2 modulates liver cancer cell migration and invasion via the Wnt5a pathway.
International journal of oncology
Liu H,Xiang Y,Zong QB,Dai ZT,Wu H,Zhang HM,Huang Y,Shen C,Wang J,Lu ZX,Ponnambalam S,Chen K,Wu Y,Zhang TC,Liao XH
Wed Jun 01 00:00:00 EDT 2022
TDO2 modulates liver cancer cell migration and invasion via the Wnt5a pathway.
International journal of oncology
Liu H,Xiang Y,Zong QB,Dai ZT,Wu H,Zhang HM,Huang Y,Shen C,Wang J,Lu ZX,Ponnambalam S,Chen K,Wu Y,Zhang TC,Liao XH
Wed Jun 01 00:00:00 EDT 2022
TDO2 modulates liver cancer cell migration and invasion via the Wnt5a pathway.
International journal of oncology
Liu H,Xiang Y,Zong QB,Dai ZT,Wu H,Zhang HM,Huang Y,Shen C,Wang J,Lu ZX,Ponnambalam S,Chen K,Wu Y,Zhang TC,Liao XH
Wed Jun 01 00:00:00 EDT 2022
TDO2 modulates liver cancer cell migration and invasion via the Wnt5a pathway.
International journal of oncology
Liu H,Xiang Y,Zong QB,Dai ZT,Wu H,Zhang HM,Huang Y,Shen C,Wang J,Lu ZX,Ponnambalam S,Chen K,Wu Y,Zhang TC,Liao XH
Wed Jun 01 00:00:00 EDT 2022
Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.
Reproductive sciences (Thousand Oaks, Calif.)
Hutchinson AP,Yin P,Neale I,Coon JS,Kujawa SA,Liu S,Bulun SE
Tue Mar 01 00:00:00 EST 2022
Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy.
Cell reports
DeVito NC,Sturdivant M,Thievanthiran B,Xiao C,Plebanek MP,Salama AKS,Beasley GM,Holtzhausen A,Novotny-Diermayr V,Strickler JH,Hanks BA
Tue May 04 00:00:00 EDT 2021
Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.
Chemical research in toxicology
Tan B,Chen J,Qin S,Liao C,Zhang Y,Wang D,Li S,Zhang Z,Zhang P,Xu F
Mon Jul 19 00:00:00 EDT 2021
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.
Transgenic research
Li S,Li S,Zhao Y,Zhang B,Wang X,Yang X,Wang Y,Jia C,Chang Y,Wei W
Wed Dec 01 00:00:00 EST 2021
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.
Transgenic research
Li S,Li S,Zhao Y,Zhang B,Wang X,Yang X,Wang Y,Jia C,Chang Y,Wei W
Wed Dec 01 00:00:00 EST 2021
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.
Transgenic research
Li S,Li S,Zhao Y,Zhang B,Wang X,Yang X,Wang Y,Jia C,Chang Y,Wei W
Wed Dec 01 00:00:00 EST 2021
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.
Transgenic research
Li S,Li S,Zhao Y,Zhang B,Wang X,Yang X,Wang Y,Jia C,Chang Y,Wei W
Wed Dec 01 00:00:00 EST 2021
Tryptophan catabolism is dysregulated in leiomyomas.
Fertility and sterility
Chuang TD,Quintanilla D,Boos D,Khorram O
Fri Oct 01 00:00:00 EDT 2021
Tryptophan catabolism is dysregulated in leiomyomas.
Fertility and sterility
Chuang TD,Quintanilla D,Boos D,Khorram O
Fri Oct 01 00:00:00 EDT 2021
Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans.
Antioxidants (Basel, Switzerland)
Wyckelsma VL,Trepci A,Schwieler L,Venckunas T,Brazaitis M,Kamandulis S,Paulauskas H,Gapeyeva H,Pääsuke M,Gastaldello S,Imbeault S,Westerblad H,Erhardt S,Andersson DC
Fri Sep 10 00:00:00 EDT 2021
Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).
European journal of medicinal chemistry
Pan S,Zhou Y,Wang Q,Wang Y,Tian C,Wang T,Huang L,Nan J,Li L,Yang S
Tue Dec 01 00:00:00 EST 2020
Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.
Toxicology and applied pharmacology
Ebokaiwe AP,Njoya EM,Sheng Y,Zhang Z,Li S,Zhou Z,Qiang Z,Peng T,Hussein AA,Zhang G,Lu X,Li L,Wang F
Thu Oct 01 00:00:00 EDT 2020
Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO).
Bioorganic chemistry
Zhang S,Guo L,Yang D,Xing Z,Li W,Kuang C,Yang Q
Sun Nov 01 00:00:00 EDT 2020
Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.
Molecular metabolism
Hughey CC,James FD,Wang Z,Goelzer M,Wasserman DH
Wed May 01 00:00:00 EDT 2019
The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis.
Signal transduction and targeted therapy
Liang H,Chen M,Qi F,Shi L,Duan Z,Yang R,He J,Lou B,Li Y,Yang Q
Mon Feb 01 00:00:00 EST 2021
The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis.
Signal transduction and targeted therapy
Liang H,Chen M,Qi F,Shi L,Duan Z,Yang R,He J,Lou B,Li Y,Yang Q
Mon Feb 01 00:00:00 EST 2021
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
European journal of medicinal chemistry
Zhang S,Qi F,Fang X,Yang D,Hu H,Huang Q,Kuang C,Yang Q
Wed Dec 05 00:00:00 EST 2018
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
European journal of medicinal chemistry
Zhang S,Qi F,Fang X,Yang D,Hu H,Huang Q,Kuang C,Yang Q
Wed Dec 05 00:00:00 EST 2018
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Cancer cell
Tummala KS,Gomes AL,Yilmaz M,Graña O,Bakiri L,Ruppen I,Ximénez-Embún P,Sheshappanavar V,Rodriguez-Justo M,Pisano DG,Wagner EF,Djouder N
Mon Dec 08 00:00:00 EST 2014
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Cancer cell
Tummala KS,Gomes AL,Yilmaz M,Graña O,Bakiri L,Ruppen I,Ximénez-Embún P,Sheshappanavar V,Rodriguez-Justo M,Pisano DG,Wagner EF,Djouder N
Mon Dec 08 00:00:00 EST 2014
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Cancer cell
Tummala KS,Gomes AL,Yilmaz M,Graña O,Bakiri L,Ruppen I,Ximénez-Embún P,Sheshappanavar V,Rodriguez-Justo M,Pisano DG,Wagner EF,Djouder N
Mon Dec 08 00:00:00 EST 2014
