Product References
TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.
Neuropathology and applied neurobiology
van Hummel A,Sabale M,Przybyla M,van der Hoven J,Chan G,Feiten AF,Chung RS,Ittner LM,Ke YD
Sat Apr 01 00:00:00 EDT 2023
Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
Molecular therapy. Nucleic acids
Takeuchi T,Maeta K,Ding X,Oe Y,Takeda A,Inoue M,Nagano S,Fujihara T,Matsuda S,Ishigaki S,Sahashi K,Minakawa EN,Mochizuki H,Neya M,Sobue G,Nagai Y
Tue Mar 14 00:00:00 EDT 2023
Distinctive chaperonopathy in skeletal muscle associated with the dominant variant in DNAJB4.
Acta neuropathologica
Inoue M,Noguchi S,Inoue YU,Iida A,Ogawa M,Bengoechea R,Pittman SK,Hayashi S,Watanabe K,Hosoi Y,Sano T,Takao M,Oya Y,Takahashi Y,Miyajima H,Weihl CC,Inoue T,Nishino I
Wed Feb 01 00:00:00 EST 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 EDT 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 EDT 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 EDT 2023
Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Science advances
Licht-Murava A,Meadows SM,Palaguachi F,Song SC,Jackvony S,Bram Y,Zhou C,Schwartz RE,Froemke RC,Orr AL,Orr AG
Fri Apr 21 00:00:00 EDT 2023
Pathological Comparison of TDP-43 Between Motor Neurons and Interneurons Expressed by a Tetracycline Repressor System on the Mouse Artificial Chromosome.
Yonago acta medica
Togai S,Hamamichi S,Kazuki Y,Hiratsuka M
Wed Feb 01 00:00:00 EST 2023
Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system.
Progress in neurobiology
Reale LA,Dyer MS,Perry SE,Young KM,Dickson TC,Woodhouse A,Blizzard CA
Sat Jul 01 00:00:00 EDT 2023
Pathologically mislocalised TDP-43 in upper motor neurons causes a die-forward spread of ALS-like pathogenic changes throughout the mouse corticomotor system.
Progress in neurobiology
Reale LA,Dyer MS,Perry SE,Young KM,Dickson TC,Woodhouse A,Blizzard CA
Sat Jul 01 00:00:00 EDT 2023
Tandem detergent-extraction and immunoprecipitation of proteinopathy: Scalable enrichment of ALS-associated TDP-43 aggregates.
iScience
Evangelista BA,Cahalan SR,Ragusa JV,Mordant A,Necarsulmer JC,Perna RJ,Ajit T,White K,Barker NK,Tian X,Cohen S,Meeker R,Herring LE,Cohen TJ
Fri May 19 00:00:00 EDT 2023
Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.
Brain pathology (Zurich, Switzerland)
Cooper-Knock J,Julian TH,Feneberg E,Highley JR,Sidra M,Turner MR,Talbot K,Ansorge O,Allen SP,Moll T,Shelkovnikova T,Castelli L,Hautbergue GM,Hewitt C,Kirby J,Wharton SB,Mead RJ,Shaw PJ
Sun Jan 01 00:00:00 EST 2023
Detection of Pathological Markers of Neurodegenerative Diseases following Microfluidic Direct Conversion of Patient Fibroblasts into Neurons.
International journal of molecular sciences
Mollinari C,De Dominicis C,Lupacchini L,Sansone L,Caprini D,Casciola CM,Wang Y,Zhao J,Fini M,Russo M,Garaci E,Merlo D
Tue Feb 15 00:00:00 EST 2022
miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy.
Neurobiology of disease
Tsitkanou S,Della Gatta PA,Abbott G,Wallace MA,Lindsay A,Gerlinger-Romero F,Walker AK,Foletta VC,Russell AP
Sat Jan 01 00:00:00 EST 2022
miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy.
Neurobiology of disease
Tsitkanou S,Della Gatta PA,Abbott G,Wallace MA,Lindsay A,Gerlinger-Romero F,Walker AK,Foletta VC,Russell AP
Sat Jan 01 00:00:00 EST 2022
Pathological changes induced by Alzheimer's brain inoculation in amyloid-beta plaque-bearing mice.
Acta neuropathologica communications
Lam S,Hérard AS,Boluda S,Petit F,Eddarkaoui S,Cambon K,Picq JL,Buée L,Duyckaerts C,Haïk S,Dhenain M
Tue Aug 16 00:00:00 EDT 2022
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature
Jiang YX,Cao Q,Sawaya MR,Abskharon R,Ge P,DeTure M,Dickson DW,Fu JY,Ogorzalek Loo RR,Loo JA,Eisenberg DS
Sun May 01 00:00:00 EDT 2022
Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43A315T Mouse Model of Amyotrophic Lateral Sclerosis.
Molecular neurobiology
Handley EE,Reale LA,Chuckowree JA,Dyer MS,Barnett GL,Clark CM,Bennett W,Dickson TC,Blizzard CA
Sun May 01 00:00:00 EDT 2022
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nature neuroscience
Xie M,Liu YU,Zhao S,Zhang L,Bosco DB,Pang YP,Zhong J,Sheth U,Martens YA,Zhao N,Liu CC,Zhuang Y,Wang L,Dickson DW,Mattson MP,Bu G,Wu LJ
Sat Jan 01 00:00:00 EST 2022
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nature neuroscience
Xie M,Liu YU,Zhao S,Zhang L,Bosco DB,Pang YP,Zhong J,Sheth U,Martens YA,Zhao N,Liu CC,Zhuang Y,Wang L,Dickson DW,Mattson MP,Bu G,Wu LJ
Sat Jan 01 00:00:00 EST 2022
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration.
Nature neuroscience
Xie M,Liu YU,Zhao S,Zhang L,Bosco DB,Pang YP,Zhong J,Sheth U,Martens YA,Zhao N,Liu CC,Zhuang Y,Wang L,Dickson DW,Mattson MP,Bu G,Wu LJ
Sat Jan 01 00:00:00 EST 2022
A single-cell atlas of human and mouse white adipose tissue.
Nature
Emont MP,Jacobs C,Essene AL,Pant D,Tenen D,Colleluori G,Di Vincenzo A,Jørgensen AM,Dashti H,Stefek A,McGonagle E,Strobel S,Laber S,Agrawal S,Westcott GP,Kar A,Veregge ML,Gulko A,Srinivasan H,Kramer Z,De Filippis E,Merkel E,Ducie J,Boyd CG,Gourash W,Courcoulas A,Lin SJ,Lee BT,Morris D,Tobias A,Khera AV,Claussnitzer M,Pers TH,Giordano A,Ashenberg O,Regev A,Tsai LT,Rosen ED
Tue Mar 01 00:00:00 EST 2022
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
The EMBO journal
Gruijs da Silva LA,Simonetti F,Hutten S,Riemenschneider H,Sternburg EL,Pietrek LM,Gebel J,Dötsch V,Edbauer D,Hummer G,Stelzl LS,Dormann D
Tue Apr 19 00:00:00 EDT 2022
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
The EMBO journal
Gruijs da Silva LA,Simonetti F,Hutten S,Riemenschneider H,Sternburg EL,Pietrek LM,Gebel J,Dötsch V,Edbauer D,Hummer G,Stelzl LS,Dormann D
Tue Apr 19 00:00:00 EDT 2022
Extremely Early-Onset Frontotemporal Dementia: A Case Report and Literature Review.
Journal of Alzheimer's disease : JAD
Chu M,Liu L,Nan H,Jiang D,Wang Y,Rosa-Neto P,Piao Y,Wu L
Wed Nov 30 00:00:00 EST 2022
Frontotemporal Lobar Degeneration Case with an N-Terminal TUBA4A Mutation Exhibits Reduced TUBA4A Levels in the Brain and TDP-43 Pathology.
Biomolecules
Van Schoor E,Vandenbulcke M,Bercier V,Vandenberghe R,van der Zee J,Van Broeckhoven C,Otto M,Hanseeuw B,Van Damme P,Van Den Bosch L,Thal DR
Sat Mar 12 00:00:00 EST 2022
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43.
Science advances
Cascella R,Bigi A,Riffert DG,Gagliani MC,Ermini E,Moretti M,Cortese K,Cecchi C,Chiti F
Fri Jul 29 00:00:00 EDT 2022
Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models.
iScience
Devoy A,Price G,De Giorgio F,Bunton-Stasyshyn R,Thompson D,Gasco S,Allan A,Codner GF,Nair RR,Tibbit C,McLeod R,Ali Z,Noda J,Marrero-Gagliardi A,Brito-Armas JM,Williams C,Öztürk MM,Simon M,O'Neill E,Bryce-Smith S,Harrison J,Atkins G,Corrochano S,Stewart M,Gilthorpe JD,Teboul L,Acevedo-Arozena A,Fisher EMC,Cunningham TJ
Fri Dec 17 00:00:00 EST 2021
Cytoplasmic Human TDP-43 Mislocalization Induces Widespread Dendritic Spine Loss in Mouse Upper Motor Neurons.
Brain sciences
Dyer MS,Woodhouse A,Blizzard CA
Wed Jun 30 00:00:00 EDT 2021
CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing.
Nanomaterials (Basel, Switzerland)
Tosat-Bitrián C,Avis-Bodas A,Porras G,Borrego-Hernández D,García-Redondo A,Martín-Requero A,Palomo V
Tue Mar 09 00:00:00 EST 2021
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice.
Acta neuropathologica communications
Ding X,Xiang Z,Qin C,Chen Y,Tian H,Meng L,Xia D,Liu H,Song J,Fu J,Ma M,Wang X
Mon Jan 18 00:00:00 EST 2021
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice.
Acta neuropathologica communications
Ding X,Xiang Z,Qin C,Chen Y,Tian H,Meng L,Xia D,Liu H,Song J,Fu J,Ma M,Wang X
Mon Jan 18 00:00:00 EST 2021
Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles.
Pharmaceutics
Rojas-Prats E,Tosat-Bitrián C,Martínez-González L,Nozal V,Pérez DI,Martínez A
Thu Jan 28 00:00:00 EST 2021
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lin LT,Razzaq A,Di Gregorio SE,Hong S,Charles B,Lopes MH,Beraldo F,Prado VF,Prado MAM,Duennwald ML
Sat May 01 00:00:00 EDT 2021
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lin LT,Razzaq A,Di Gregorio SE,Hong S,Charles B,Lopes MH,Beraldo F,Prado VF,Prado MAM,Duennwald ML
Sat May 01 00:00:00 EDT 2021
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lin LT,Razzaq A,Di Gregorio SE,Hong S,Charles B,Lopes MH,Beraldo F,Prado VF,Prado MAM,Duennwald ML
Sat May 01 00:00:00 EDT 2021
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lin LT,Razzaq A,Di Gregorio SE,Hong S,Charles B,Lopes MH,Beraldo F,Prado VF,Prado MAM,Duennwald ML
Sat May 01 00:00:00 EDT 2021
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lin LT,Razzaq A,Di Gregorio SE,Hong S,Charles B,Lopes MH,Beraldo F,Prado VF,Prado MAM,Duennwald ML
Sat May 01 00:00:00 EDT 2021
Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lin LT,Razzaq A,Di Gregorio SE,Hong S,Charles B,Lopes MH,Beraldo F,Prado VF,Prado MAM,Duennwald ML
Sat May 01 00:00:00 EDT 2021
TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.
Nature communications
Baek M,Choe YJ,Bannwarth S,Kim J,Maitra S,Dorn GW,Taylor JP,Paquis-Flucklinger V,Kim NC
Fri Mar 26 00:00:00 EDT 2021
RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases.
Acta neuropathologica communications
Collins M,Li Y,Bowser R
Fri Jun 26 00:00:00 EDT 2020
Neurodegeneration and Motor Deficits in the Absence of Astrogliosis upon Transgenic Mutant TDP-43 Expression in Mature Mice.
The American journal of pathology
Chan G,van Hummel A,van der Hoven J,Ittner LM,Ke YD
Sat Aug 01 00:00:00 EDT 2020
Neurodegeneration and Motor Deficits in the Absence of Astrogliosis upon Transgenic Mutant TDP-43 Expression in Mature Mice.
The American journal of pathology
Chan G,van Hummel A,van der Hoven J,Ittner LM,Ke YD
Sat Aug 01 00:00:00 EDT 2020
Homozygous GRN mutations: new phenotypes and new insights into pathological and molecular mechanisms.
Brain : a journal of neurology
Huin V,Barbier M,Bottani A,Lobrinus JA,Clot F,Lamari F,Chat L,Rucheton B,Fluchère F,Auvin S,Myers P,Gelot A,Camuzat A,Caillaud C,Jornéa L,Forlani S,Saracino D,Duyckaerts C,Brice A,Durr A,Le Ber I
Wed Jan 01 00:00:00 EST 2020
ALS skin fibroblasts reveal oxidative stress and ERK1/2-mediated cytoplasmic localization of TDP-43.
Cellular signalling
Romano N,Catalani A,Lattante S,Belardo A,Proietti S,Bertini L,Silvestri F,Catalani E,Cervia D,Zolla L,Sabatelli M,Welshhans K,Ceci M
Mon Jun 01 00:00:00 EDT 2020
ALS skin fibroblasts reveal oxidative stress and ERK1/2-mediated cytoplasmic localization of TDP-43.
Cellular signalling
Romano N,Catalani A,Lattante S,Belardo A,Proietti S,Bertini L,Silvestri F,Catalani E,Cervia D,Zolla L,Sabatelli M,Welshhans K,Ceci M
Mon Jun 01 00:00:00 EDT 2020
Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation.
Biomolecules
Fernandes N,Nero L,Lyons SM,Ivanov P,Mittelmeier TM,Bolger TA,Buchan JR
Fri Sep 25 00:00:00 EDT 2020
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Nature neuroscience
Laferrière F,Maniecka Z,Pérez-Berlanga M,Hruska-Plochan M,Gilhespy L,Hock EM,Wagner U,Afroz T,Boersema PJ,Barmettler G,Foti SC,Asi YT,Isaacs AM,Al-Amoudi A,Lewis A,Stahlberg H,Ravits J,De Giorgi F,Ichas F,Bezard E,Picotti P,Lashley T,Polymenidou M
Tue Jan 01 00:00:00 EST 2019
Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.
Neurobiology of disease
Gordon D,Dafinca R,Scaber J,Alegre-Abarrategui J,Farrimond L,Scott C,Biggs D,Kent L,Oliver PL,Davies B,Ansorge O,Wade-Martins R,Talbot K
Tue Jan 01 00:00:00 EST 2019
The role of lysosomes and autophagosomes in frontotemporal lobar degeneration.
Neuropathology and applied neurobiology
Bain HDC,Davidson YS,Robinson AC,Ryan S,Rollinson S,Richardson A,Jones M,Snowden JS,Pickering-Brown S,Mann DMA
Mon Apr 01 00:00:00 EDT 2019
Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function.
Disease models & mechanisms
Jiang T,Handley E,Brizuela M,Dawkins E,Lewis KEA,Clark RM,Dickson TC,Blizzard CA
Fri May 17 00:00:00 EDT 2019
Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients.
Frontiers in neuroscience
Sproviero D,La Salvia S,Colombo F,Zucca S,Pansarasa O,Diamanti L,Costa A,Lova L,Giannini M,Gagliardi S,Lauranzano E,Matteoli M,Ceroni M,Malaspina A,Cereda C
Sat Jan 09 00:00:00 EST 2021
Phosphorylated and aggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt) polyglutamine expression in human cellular models.
Cellular and molecular life sciences : CMLS
Coudert L,Nonaka T,Bernard E,Hasegawa M,Schaeffer L,Leblanc P
Mon Jul 01 00:00:00 EDT 2019
Multiple System Atrophy With Predominant Striatonigral Degeneration and TAR DNA-Binding Protein of 43 kDa Pathology: An Unusual Variant of Multiple System Atrophy.
Movement disorders clinical practice
Nwabuobi L,Tomishon D,Shneider NA,Fahn S,Vonsattel JP,Cortes E
Fri Nov 01 00:00:00 EDT 2019
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
The EMBO journal
Wang A,Conicella AE,Schmidt HB,Martin EW,Rhoads SN,Reeb AN,Nourse A,Ramirez Montero D,Ryan VH,Rohatgi R,Shewmaker F,Naik MT,Mittag T,Ayala YM,Fawzi NL
Thu Mar 01 00:00:00 EST 2018
RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis.
Journal of proteome research
Volkening K,Keller BA,Leystra-Lantz C,Strong MJ
Fri Apr 06 00:00:00 EDT 2018
RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis.
Journal of proteome research
Volkening K,Keller BA,Leystra-Lantz C,Strong MJ
Fri Apr 06 00:00:00 EDT 2018
Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Watanabe R,Kawakami I,Onaya M,Higashi S,Arai N,Akiyama H,Hasegawa M,Arai T
Fri Jun 01 00:00:00 EDT 2018
Frontotemporal dementia with trans-activation response DNA-binding protein 43 presenting with catatonic syndrome.
Neuropathology : official journal of the Japanese Society of Neuropathology
Watanabe R,Kawakami I,Onaya M,Higashi S,Arai N,Akiyama H,Hasegawa M,Arai T
Fri Jun 01 00:00:00 EDT 2018
Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients.
Frontiers in neuroscience
Sproviero D,La Salvia S,Giannini M,Crippa V,Gagliardi S,Bernuzzi S,Diamanti L,Ceroni M,Pansarasa O,Poletti A,Cereda C
Thu Oct 01 00:00:00 EDT 2020
mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms.
PloS one
Scherz B,Rabl R,Flunkert S,Rohler S,Neddens J,Taub N,Temmel M,Panzenboeck U,Niederkofler V,Zimmermann R,Hutter-Paier B
Mon Nov 26 00:00:00 EST 2018
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
eLife
Conlon EG,Fagegaltier D,Agius P,Davis-Porada J,Gregory J,Hubbard I,Kang K,Kim D,Phatnani H,Shneider NA,Manley JL
Fri Jul 13 00:00:00 EDT 2018
Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
eLife
Conlon EG,Fagegaltier D,Agius P,Davis-Porada J,Gregory J,Hubbard I,Kang K,Kim D,Phatnani H,Shneider NA,Manley JL
Fri Jul 13 00:00:00 EDT 2018
ALS/FTLD: experimental models and reality.
Acta neuropathologica
Tan RH,Ke YD,Ittner LM,Halliday GM
Wed Feb 01 00:00:00 EST 2017
ALS/FTLD: experimental models and reality.
Acta neuropathologica
Tan RH,Ke YD,Ittner LM,Halliday GM
Wed Feb 01 00:00:00 EST 2017
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Human molecular genetics
Tanaka Y,Suzuki G,Matsuwaki T,Hosokawa M,Serrano G,Beach TG,Yamanouchi K,Hasegawa M,Nishihara M
Wed Mar 01 00:00:00 EST 2017
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Human molecular genetics
Tanaka Y,Suzuki G,Matsuwaki T,Hosokawa M,Serrano G,Beach TG,Yamanouchi K,Hasegawa M,Nishihara M
Wed Mar 01 00:00:00 EST 2017
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Human molecular genetics
Tanaka Y,Suzuki G,Matsuwaki T,Hosokawa M,Serrano G,Beach TG,Yamanouchi K,Hasegawa M,Nishihara M
Wed Mar 01 00:00:00 EST 2017
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Human molecular genetics
Tanaka Y,Suzuki G,Matsuwaki T,Hosokawa M,Serrano G,Beach TG,Yamanouchi K,Hasegawa M,Nishihara M
Wed Mar 01 00:00:00 EST 2017
Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.
Cerebral cortex (New York, N.Y. : 1991)
Handley EE,Pitman KA,Dawkins E,Young KM,Clark RM,Jiang TC,Turner BJ,Dickson TC,Blizzard CA
Sat Jul 01 00:00:00 EDT 2017
Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.
Cerebral cortex (New York, N.Y. : 1991)
Handley EE,Pitman KA,Dawkins E,Young KM,Clark RM,Jiang TC,Turner BJ,Dickson TC,Blizzard CA
Sat Jul 01 00:00:00 EDT 2017
Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins.
Scientific reports
Foglieni C,Papin S,Salvadè A,Afroz T,Pinton S,Pedrioli G,Ulrich G,Polymenidou M,Paganetti P
Wed Oct 25 00:00:00 EDT 2017
Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins.
Scientific reports
Foglieni C,Papin S,Salvadè A,Afroz T,Pinton S,Pedrioli G,Ulrich G,Polymenidou M,Paganetti P
Wed Oct 25 00:00:00 EDT 2017
Endocytosis regulates TDP-43 toxicity and turnover.
Nature communications
Liu G,Coyne AN,Pei F,Vaughan S,Chaung M,Zarnescu DC,Buchan JR
Tue Dec 12 00:00:00 EST 2017
Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43.
Nucleic acids research
Koyama A,Sugai A,Kato T,Ishihara T,Shiga A,Toyoshima Y,Koyama M,Konno T,Hirokawa S,Yokoseki A,Nishizawa M,Kakita A,Takahashi H,Onodera O
Fri Jul 08 00:00:00 EDT 2016
Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.
Brain : a journal of neurology
Shiihashi G,Ito D,Yagi T,Nihei Y,Ebine T,Suzuki N
Thu Sep 01 00:00:00 EDT 2016
Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.
Brain : a journal of neurology
Shiihashi G,Ito D,Yagi T,Nihei Y,Ebine T,Suzuki N
Thu Sep 01 00:00:00 EDT 2016
In vitro prion-like behaviour of TDP-43 in ALS.
Neurobiology of disease
Smethurst P,Newcombe J,Troakes C,Simone R,Chen YR,Patani R,Sidle K
Thu Dec 01 00:00:00 EST 2016
Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.
Frontiers in aging neuroscience
Alfieri JA,Silva PR,Igaz LM
Thu Oct 01 00:00:00 EDT 2020
Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.
Frontiers in aging neuroscience
Alfieri JA,Silva PR,Igaz LM
Thu Oct 01 00:00:00 EDT 2020
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Human molecular genetics
Tanaka Y,Nonaka T,Suzuki G,Kametani F,Hasegawa M
Fri Apr 01 00:00:00 EDT 2016
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Human molecular genetics
Tanaka Y,Nonaka T,Suzuki G,Kametani F,Hasegawa M
Fri Apr 01 00:00:00 EDT 2016
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Human molecular genetics
Tanaka Y,Nonaka T,Suzuki G,Kametani F,Hasegawa M
Fri Apr 01 00:00:00 EDT 2016
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.
Human molecular genetics
Tanaka Y,Nonaka T,Suzuki G,Kametani F,Hasegawa M
Fri Apr 01 00:00:00 EDT 2016
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Nature medicine
Wang W,Wang L,Lu J,Siedlak SL,Fujioka H,Liang J,Jiang S,Ma X,Jiang Z,da Rocha EL,Sheng M,Choi H,Lerou PH,Li H,Wang X
Mon Aug 01 00:00:00 EDT 2016
Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.
Scientific reports
Kametani F,Obi T,Shishido T,Akatsu H,Murayama S,Saito Y,Yoshida M,Hasegawa M
Wed Mar 16 00:00:00 EDT 2016
Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4.
Skeletal muscle
Homma S,Beermann ML,Yu B,Boyce FM,Miller JB
Thu Dec 01 00:00:00 EST 2016
Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.
The Journal of biological chemistry
Shimonaka S,Nonaka T,Suzuki G,Hisanaga S,Hasegawa M
Fri Apr 22 00:00:00 EDT 2016
Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Acta neuropathologica
Ke YD,van Hummel A,Stevens CH,Gladbach A,Ippati S,Bi M,Lee WS,Krüger S,van der Hoven J,Volkerling A,Bongers A,Halliday G,Haass NK,Kiernan M,Delerue F,Ittner LM
Sun Nov 01 00:00:00 EDT 2015
Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Acta neuropathologica
Ke YD,van Hummel A,Stevens CH,Gladbach A,Ippati S,Bi M,Lee WS,Krüger S,van der Hoven J,Volkerling A,Bongers A,Halliday G,Haass NK,Kiernan M,Delerue F,Ittner LM
Sun Nov 01 00:00:00 EDT 2015
TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons.
Neurobiology of disease
Mutihac R,Alegre-Abarrategui J,Gordon D,Farrimond L,Yamasaki-Mann M,Talbot K,Wade-Martins R
Sun Mar 01 00:00:00 EST 2015
TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons.
Neurobiology of disease
Mutihac R,Alegre-Abarrategui J,Gordon D,Farrimond L,Yamasaki-Mann M,Talbot K,Wade-Martins R
Sun Mar 01 00:00:00 EST 2015
Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation.
Annals of clinical and translational neurology
Homma S,Beermann ML,Boyce FM,Miller JB
Sun Feb 01 00:00:00 EST 2015
Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation.
Annals of clinical and translational neurology
Homma S,Beermann ML,Boyce FM,Miller JB
Sun Feb 01 00:00:00 EST 2015
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Human molecular genetics
Henriques A,Croixmarie V,Priestman DA,Rosenbohm A,Dirrig-Grosch S,D'Ambra E,Huebecker M,Hussain G,Boursier-Neyret C,Echaniz-Laguna A,Ludolph AC,Platt FM,Walther B,Spedding M,Loeffler JP,Gonzalez De Aguilar JL
Sun Dec 20 00:00:00 EST 2015
Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase.
Human molecular genetics
Henriques A,Croixmarie V,Priestman DA,Rosenbohm A,Dirrig-Grosch S,D'Ambra E,Huebecker M,Hussain G,Boursier-Neyret C,Echaniz-Laguna A,Ludolph AC,Platt FM,Walther B,Spedding M,Loeffler JP,Gonzalez De Aguilar JL
Sun Dec 20 00:00:00 EST 2015
Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis.
Human molecular genetics
Osaka M,Ito D,Yagi T,Nihei Y,Suzuki N
Sun Mar 15 00:00:00 EDT 2015
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Molecular and cellular biology
Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R
Wed Jul 01 00:00:00 EDT 2015
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Molecular and cellular biology
Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R
Wed Jul 01 00:00:00 EDT 2015
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.
Acta neuropathologica communications
Goossens J,Vanmechelen E,Trojanowski JQ,Lee VM,Van Broeckhoven C,van der Zee J,Engelborghs S
Wed Apr 01 00:00:00 EDT 2015
TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.
Acta neuropathologica communications
Goossens J,Vanmechelen E,Trojanowski JQ,Lee VM,Van Broeckhoven C,van der Zee J,Engelborghs S
Wed Apr 01 00:00:00 EDT 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 EST 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 EST 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 EST 2015
An acetylation switch controls TDP-43 function and aggregation propensity.
Nature communications
Cohen TJ,Hwang AW,Restrepo CR,Yuan CX,Trojanowski JQ,Lee VM
Mon Jan 05 00:00:00 EST 2015
Clinicopathological features of the first Asian family having vocal cord and pharyngeal weakness with distal myopathy due to a MATR3 mutation.
Neuropathology and applied neurobiology
Yamashita S,Mori A,Nishida Y,Kurisaki R,Tawara N,Nishikami T,Misumi Y,Ueyama H,Imamura S,Higuchi Y,Hashiguchi A,Higuchi I,Morishita S,Yoshimura J,Uchino M,Takashima H,Tsuji S,Ando Y
Wed Apr 01 00:00:00 EDT 2015
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation.
Journal of neurology, neurosurgery, and psychiatry
Suárez-Calvet M,Dols-Icardo O,Lladó A,Sánchez-Valle R,Hernández I,Amer G,Antón-Aguirre S,Alcolea D,Fortea J,Ferrer I,van der Zee J,Dillen L,Van Broeckhoven C,Molinuevo JL,Blesa R,Clarimón J,Lleó A
Sun Jun 01 00:00:00 EDT 2014
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation.
Journal of neurology, neurosurgery, and psychiatry
Suárez-Calvet M,Dols-Icardo O,Lladó A,Sánchez-Valle R,Hernández I,Amer G,Antón-Aguirre S,Alcolea D,Fortea J,Ferrer I,van der Zee J,Dillen L,Van Broeckhoven C,Molinuevo JL,Blesa R,Clarimón J,Lleó A
Sun Jun 01 00:00:00 EDT 2014
Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Alfieri JA,Pino NS,Igaz LM
Wed Nov 12 00:00:00 EST 2014
Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Alfieri JA,Pino NS,Igaz LM
Wed Nov 12 00:00:00 EST 2014
Distinct pathways leading to TDP-43-induced cellular dysfunctions.
Human molecular genetics
Yamashita M,Nonaka T,Hirai S,Miwa A,Okado H,Arai T,Hosokawa M,Akiyama H,Hasegawa M
Fri Aug 15 00:00:00 EDT 2014
Distinct pathways leading to TDP-43-induced cellular dysfunctions.
Human molecular genetics
Yamashita M,Nonaka T,Hirai S,Miwa A,Okado H,Arai T,Hosokawa M,Akiyama H,Hasegawa M
Fri Aug 15 00:00:00 EDT 2014
Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.
The International journal of neuroscience
Hosokawa M,Arai T,Yamashita M,Tsuji H,Nonaka T,Masuda-Suzukake M,Tamaoka A,Hasegawa M,Akiyama H
Thu May 01 00:00:00 EDT 2014
An autopsy case of sporadic amyotrophic lateral sclerosis associated with the I113T SOD1 mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Nakamura S,Wate R,Kaneko S,Ito H,Oki M,Tsuge A,Nagashima M,Asayama S,Fujita K,Nakamura M,Maruyama H,Kawakami H,Kusaka H
Sat Feb 01 00:00:00 EST 2014
An autopsy case of sporadic amyotrophic lateral sclerosis associated with the I113T SOD1 mutation.
Neuropathology : official journal of the Japanese Society of Neuropathology
Nakamura S,Wate R,Kaneko S,Ito H,Oki M,Tsuge A,Nagashima M,Asayama S,Fujita K,Nakamura M,Maruyama H,Kawakami H,Kusaka H
Sat Feb 01 00:00:00 EST 2014
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.
Molecular neurodegeneration
Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P
Tue Jun 17 00:00:00 EDT 2014
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.
Molecular neurodegeneration
Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P
Tue Jun 17 00:00:00 EDT 2014
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.
Annals of neurology
Larman HB,Salajegheh M,Nazareno R,Lam T,Sauld J,Steen H,Kong SW,Pinkus JL,Amato AA,Elledge SJ,Greenberg SA
Fri Mar 01 00:00:00 EST 2013
Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.
Annals of neurology
Larman HB,Salajegheh M,Nazareno R,Lam T,Sauld J,Steen H,Kong SW,Pinkus JL,Amato AA,Elledge SJ,Greenberg SA
Fri Mar 01 00:00:00 EST 2013
The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.
Human molecular genetics
Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L
Thu Aug 01 00:00:00 EDT 2013
The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.
Human molecular genetics
Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L
Thu Aug 01 00:00:00 EDT 2013
A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.
Neuroscience research
Akamatsu M,Takuma H,Yamashita T,Okada T,Keino-Masu K,Ishii K,Kwak S,Masu M,Tamaoka A
Sun Dec 01 00:00:00 EST 2013
A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation.
Neuroscience research
Akamatsu M,Takuma H,Yamashita T,Okada T,Keino-Masu K,Ishii K,Kwak S,Masu M,Tamaoka A
Sun Dec 01 00:00:00 EST 2013
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.
Biochimica et biophysica acta
Cassel JA,Reitz AB
Sat Jun 01 00:00:00 EDT 2013
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.
Biochimica et biophysica acta
Cassel JA,Reitz AB
Sat Jun 01 00:00:00 EDT 2013
Prion-like properties of pathological TDP-43 aggregates from diseased brains.
Cell reports
Nonaka T,Masuda-Suzukake M,Arai T,Hasegawa Y,Akatsu H,Obi T,Yoshida M,Murayama S,Mann DM,Akiyama H,Hasegawa M
Thu Jul 11 00:00:00 EDT 2013
Prion-like properties of pathological TDP-43 aggregates from diseased brains.
Cell reports
Nonaka T,Masuda-Suzukake M,Arai T,Hasegawa Y,Akatsu H,Obi T,Yoshida M,Murayama S,Mann DM,Akiyama H,Hasegawa M
Thu Jul 11 00:00:00 EDT 2013
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 EDT 2014
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 EDT 2014
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 EDT 2014
TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
PloS one
Stallings NR,Puttaparthi K,Dowling KJ,Luther CM,Burns DK,Davis K,Elliott JL
Wed May 14 00:00:00 EDT 2014
Molecular analysis and biochemical classification of TDP-43 proteinopathy.
Brain : a journal of neurology
Tsuji H,Arai T,Kametani F,Nonaka T,Yamashita M,Suzukake M,Hosokawa M,Yoshida M,Hatsuta H,Takao M,Saito Y,Murayama S,Akiyama H,Hasegawa M,Mann DM,Tamaoka A
Thu Nov 01 00:00:00 EDT 2012
Molecular analysis and biochemical classification of TDP-43 proteinopathy.
Brain : a journal of neurology
Tsuji H,Arai T,Kametani F,Nonaka T,Yamashita M,Suzukake M,Hosokawa M,Yoshida M,Hatsuta H,Takao M,Saito Y,Murayama S,Akiyama H,Hasegawa M,Mann DM,Tamaoka A
Thu Nov 01 00:00:00 EDT 2012
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal
Cohen TJ,Hwang AW,Unger T,Trojanowski JQ,Lee VM
Wed Mar 07 00:00:00 EST 2012
Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
The EMBO journal
Cohen TJ,Hwang AW,Unger T,Trojanowski JQ,Lee VM
Wed Mar 07 00:00:00 EST 2012
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease
González-Pérez P,Lu Y,Chian RJ,Sapp PC,Tanzi RE,Bertram L,McKenna-Yasek D,Gao FB,Brown RH
Sat Dec 01 00:00:00 EST 2012
Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.
Neurobiology of disease
González-Pérez P,Lu Y,Chian RJ,Sapp PC,Tanzi RE,Bertram L,McKenna-Yasek D,Gao FB,Brown RH
Sat Dec 01 00:00:00 EST 2012
Inclusion body myositis coexisting with hypertrophic cardiomyopathy: an autopsy study.
Neuromuscular disorders : NMD
Inamori Y,Higuchi I,Inoue T,Sakiyama Y,Hashiguchi A,Higashi K,Shiraishi T,Okubo R,Arimura K,Mitsuyama Y,Takashima H
Wed Aug 01 00:00:00 EDT 2012
Inclusion body myositis coexisting with hypertrophic cardiomyopathy: an autopsy study.
Neuromuscular disorders : NMD
Inamori Y,Higuchi I,Inoue T,Sakiyama Y,Hashiguchi A,Higashi K,Shiraishi T,Okubo R,Arimura K,Mitsuyama Y,Takashima H
Wed Aug 01 00:00:00 EDT 2012
Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Biochemical and biophysical research communications
Tsuji H,Nonaka T,Yamashita M,Masuda-Suzukake M,Kametani F,Akiyama H,Mann DM,Tamaoka A,Hasegawa M
Fri Jan 06 00:00:00 EST 2012
Epitope mapping of antibodies against TDP-43 and detection of protease-resistant fragments of pathological TDP-43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Biochemical and biophysical research communications
Tsuji H,Nonaka T,Yamashita M,Masuda-Suzukake M,Kametani F,Akiyama H,Mann DM,Tamaoka A,Hasegawa M
Fri Jan 06 00:00:00 EST 2012
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
PloS one
Dammer EB,Fallini C,Gozal YM,Duong DM,Rossoll W,Xu P,Lah JJ,Levey AI,Peng J,Bassell GJ,Seyfried NT
Tue Mar 26 00:00:00 EDT 2013
Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.
PloS one
Dammer EB,Fallini C,Gozal YM,Duong DM,Rossoll W,Xu P,Lah JJ,Levey AI,Peng J,Bassell GJ,Seyfried NT
Tue Mar 26 00:00:00 EDT 2013
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T
Sun Aug 21 00:00:00 EDT 2011
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T
Sun Aug 21 00:00:00 EDT 2011
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
Nature
Deng HX,Chen W,Hong ST,Boycott KM,Gorrie GH,Siddique N,Yang Y,Fecto F,Shi Y,Zhai H,Jiang H,Hirano M,Rampersaud E,Jansen GH,Donkervoort S,Bigio EH,Brooks BR,Ajroud K,Sufit RL,Haines JL,Mugnaini E,Pericak-Vance MA,Siddique T
Sun Aug 21 00:00:00 EDT 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 EST 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 EST 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 EST 2011
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
The Journal of clinical investigation
Igaz LM,Kwong LK,Lee EB,Chen-Plotkin A,Swanson E,Unger T,Malunda J,Xu Y,Winton MJ,Trojanowski JQ,Lee VM
Tue Feb 01 00:00:00 EST 2011
Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice.
Experimental neurology
Necchi D,Lomoio S,Scherini E
Thu Dec 01 00:00:00 EST 2011
AMSH is required to degrade ubiquitinated proteins in the central nervous system.
Biochemical and biophysical research communications
Suzuki S,Tamai K,Watanabe M,Kyuuma M,Ono M,Sugamura K,Tanaka N
Fri May 20 00:00:00 EDT 2011
AMSH is required to degrade ubiquitinated proteins in the central nervous system.
Biochemical and biophysical research communications
Suzuki S,Tamai K,Watanabe M,Kyuuma M,Ono M,Sugamura K,Tanaka N
Fri May 20 00:00:00 EDT 2011
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 EDT 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 EDT 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 EDT 2010
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Annals of neurology
Deng HX,Zhai H,Bigio EH,Yan J,Fecto F,Ajroud K,Mishra M,Ajroud-Driss S,Heller S,Sufit R,Siddique N,Mugnaini E,Siddique T
Tue Jun 01 00:00:00 EDT 2010
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
The Journal of biological chemistry
Nishimoto Y,Ito D,Yagi T,Nihei Y,Tsunoda Y,Suzuki N
Fri Jan 01 00:00:00 EST 2010
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
The Journal of biological chemistry
Nishimoto Y,Ito D,Yagi T,Nihei Y,Tsunoda Y,Suzuki N
Fri Jan 01 00:00:00 EST 2010
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 EST 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 EST 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 EST 2008
TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system.
Acta neuropathologica
Lee EB,Lee VM,Trojanowski JQ,Neumann M
Sat Mar 01 00:00:00 EST 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 EDT 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 EDT 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 EDT 2008
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease.
Brain research
Rohn TT
Thu Sep 04 00:00:00 EDT 2008
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology
Steinacker P,Hendrich C,Sperfeld AD,Jesse S,von Arnim CA,Lehnert S,Pabst A,Uttner I,Tumani H,Lee VM,Trojanowski JQ,Kretzschmar HA,Ludolph A,Neumann M,Otto M
Sat Nov 01 00:00:00 EDT 2008
TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Archives of neurology
Steinacker P,Hendrich C,Sperfeld AD,Jesse S,von Arnim CA,Lehnert S,Pabst A,Uttner I,Tumani H,Lee VM,Trojanowski JQ,Kretzschmar HA,Ludolph A,Neumann M,Otto M
Sat Nov 01 00:00:00 EDT 2008
