Proteintech

TDP-43 (C-terminal) Polyclonal Antibody

TDP-43 (C-terminal) Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 21

TDP-43 (C-terminal) Antibody (12892-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 12892-1-AP (TDP-43 (C-terminal) antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TDP-43 (C-terminal) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TDP-43 (C-terminal) Antibody in Western Blot (WB)

TDP-43 (C-terminal) Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12892-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 123 publications 123 publications

Immunohistochemistry (IHC)

View 37 publications 37 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:2,000

Immunocytochemistry (ICC/IF)

1:50-1:500

View 75 publications 75 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 10 publications 10 publications

ChIP assay (ChIP)

Assay-dependent

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 8 publications 8 publications

Not applicable (N/A)

View 17 publications 17 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TDP-43 (C-terminal) Fusion Protein Ag4003

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes the cleavage product of 20-30 kDa in addition to the native and phosphorylated forms of TDP-43. Immunohistochemical analyses of TDP-43 using this antibody detect both normal diffuse nuclear staining and insoluble inclusions in pathologic tissues. Various forms of TDP-43 exist, including 18-35 kDa of cleaved C-terminal fragments, 45-50 kDa phosphoprotein, 55 kDa glycosylated form, 75 kDa hyperphosphorylated form, and 90-300 kDa cross-linked form.

Target Information

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Elevated nuclear TDP-43 induces constitutive exon skipping.

bioRxiv : the preprint server for biology

Carmen-Orozco RP,Tsao W,Ye Y,Sinha IR,Chang K,Trinh V,Chung W,Bowden K,Troncoso JC,Blackshaw S,Hayes LR,Sun S,Wong PC,Ling JP

Fri May 12 00:00:00 EDT 2023

Elevated nuclear TDP-43 induces constitutive exon skipping.

bioRxiv : the preprint server for biology

Carmen-Orozco RP,Tsao W,Ye Y,Sinha IR,Chang K,Trinh V,Chung W,Bowden K,Troncoso JC,Blackshaw S,Hayes LR,Sun S,Wong PC,Ling JP

Fri May 12 00:00:00 EDT 2023

Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Jamerlan AM,Shim KH,Youn YC,Teunissen C,An SSA,Scheltens P,Kim S

Fri Sep 01 00:00:00 EDT 2023

Acute Treatment with the M-Channel (K_v7, KCNQ) Opener Retigabine Reduces the Long-Term Effects of Repetitive Blast Traumatic Brain Injuries.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Vigil FA,Belchior H,Bugay V,Bazaldua II,Stoja A,Dantas DC,Chun SH,Farmer A,Bozdemir E,Holstein DM,Cavazos JE,Lechleiter JD,Brenner R,Shapiro MS

Sat Apr 01 00:00:00 EDT 2023

Acute Treatment with the M-Channel (K_v7, KCNQ) Opener Retigabine Reduces the Long-Term Effects of Repetitive Blast Traumatic Brain Injuries.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Vigil FA,Belchior H,Bugay V,Bazaldua II,Stoja A,Dantas DC,Chun SH,Farmer A,Bozdemir E,Holstein DM,Cavazos JE,Lechleiter JD,Brenner R,Shapiro MS

Sat Apr 01 00:00:00 EDT 2023

Patients carrying the mutation p.R406W in MAPT present with non-conforming phenotypic spectrum.

Brain : a journal of neurology

Gossye H,Van Mossevelde S,Sieben A,Bjerke M,Hendrickx Van de Craen E,van der Zee J,De Deyn PP,De Bleecker J,Versijpt J,van den Ende J,Deryck O,Bourgeois P,Bier JC,Goethals M,Vandenberghe R,Engelborghs S,Van Broeckhoven C

Wed Apr 19 00:00:00 EDT 2023

Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors.

Human molecular genetics

Ma L,Liang C,Wang J,Chang Q,Wang Y,Zhang W,Du Y,Sadan J,Chen JF

Thu Apr 06 00:00:00 EDT 2023

Neuropathological correlates of neuropsychiatric symptoms in dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Gibson LL,Grinberg LT,Ffytche D,Leite REP,Rodriguez RD,Ferretti-Rebustini REL,Pasqualucci CA,Nitrini R,Jacob-Filho W,Aarsland D,Suemoto CK

Sat Apr 01 00:00:00 EDT 2023

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders.

Nature communications

Cui Y,Arnold FJ,Peng F,Wang D,Li JS,Michels S,Wagner EJ,La Spada AR,Li W

Fri Feb 03 00:00:00 EST 2023

Single nucleus multiome analysis of the prefrontal cortex from C9orf72 ALS/FTD patients illuminates pathways affected during disease progression.

bioRxiv : the preprint server for biology

Wang HV,Veire AM,Gendron TF,Gearing M,Glass JD,Jin P,Corces VG,McEachin ZT

Fri Jan 13 00:00:00 EST 2023

Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera.

Journal of biomedical science

Tseng YL,Lu PC,Lee CC,He RY,Huang YA,Tseng YC,Cheng TR,Huang JJ,Fang JM

Wed Apr 26 00:00:00 EDT 2023

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A.

PLoS biology

Koike Y,Pickles S,Estades Ayuso V,Jansen-West K,Qi YA,Li Z,Daughrity LM,Yue M,Zhang YJ,Cook CN,Dickson DW,Ward M,Petrucelli L,Prudencio M

Wed Mar 01 00:00:00 EST 2023

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage.

Nature neuroscience

Kumar ST,Nazarov S,Porta S,Maharjan N,Cendrowska U,Kabani M,Finamore F,Xu Y,Lee VM,Lashuel HA

Thu Jun 01 00:00:00 EDT 2023

Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions.

Antioxidants (Basel, Switzerland)

Rodríguez-Periñán G,de la Encarnación A,Moreno F,López de Munain A,Martínez A,Martín-Requero Á,Alquézar C,Bartolomé F

Sat Feb 25 00:00:00 EST 2023

TDP-43 N-terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate.

FEBS letters

Miura M,Sakaue F,Matsuno H,Morita K,Yoshida A,Hara RI,Nishimura R,Nishida Y,Yokogawa M,Osawa M,Yokota T

Thu Jun 01 00:00:00 EDT 2023

Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo.

Journal of Alzheimer's disease reports

Lin NH,Goh A,Lin SH,Chuang KA,Chang CH,Li MH,Lu CH,Chen WY,Wei PH,Pan IH,Perng MD,Wen SF

Tue Mar 28 00:00:00 EDT 2023

Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo.

Journal of Alzheimer's disease reports

Lin NH,Goh A,Lin SH,Chuang KA,Chang CH,Li MH,Lu CH,Chen WY,Wei PH,Pan IH,Perng MD,Wen SF

Tue Mar 28 00:00:00 EDT 2023

C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys.

Neurobiology of disease

Xu L,Wang D,Zhao L,Yang Z,Liu X,Li X,Yuan T,Wang Y,Huang T,Bian N,He Y,Chen X,Tian B,Liu Z,Luo F,Si W,Gao G,Ji W,Niu Y,Wei J

Tue Aug 01 00:00:00 EDT 2023

Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.

Progress in neurobiology

Bai D,Zhu L,Jia Q,Duan X,Chen L,Wang X,Hou J,Jiang G,Yang S,Li S,Li XJ,Yin P

Tue Aug 01 00:00:00 EDT 2023

Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.

Progress in neurobiology

Bai D,Zhu L,Jia Q,Duan X,Chen L,Wang X,Hou J,Jiang G,Yang S,Li S,Li XJ,Yin P

Tue Aug 01 00:00:00 EDT 2023

Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice.

Progress in neurobiology

Bai D,Zhu L,Jia Q,Duan X,Chen L,Wang X,Hou J,Jiang G,Yang S,Li S,Li XJ,Yin P

Tue Aug 01 00:00:00 EDT 2023

Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.

Brain pathology (Zurich, Switzerland)

Cooper-Knock J,Julian TH,Feneberg E,Highley JR,Sidra M,Turner MR,Talbot K,Ansorge O,Allen SP,Moll T,Shelkovnikova T,Castelli L,Hautbergue GM,Hewitt C,Kirby J,Wharton SB,Mead RJ,Shaw PJ

Sun Jan 01 00:00:00 EST 2023

pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data.

The journal of pathology. Clinical research

Pattle SB,O'Shaughnessy J,Kantelberg O,Rifai OM,Pate J,Nellany K,Hays N,Arends MJ,Horrocks MH,Waldron FM,Gregory JM

Sun Jan 01 00:00:00 EST 2023

New lessons on TDP-43 from old N. furzeri killifish.

Aging cell

Louka A,Bagnoli S,Rupert J,Esapa B,Tartaglia GG,Cellerino A,Pastore A,Terzibasi Tozzini E

Sat Jan 01 00:00:00 EST 2022

USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance.

Molecular and cellular biology

Takahashi M,Kitaura H,Kakita A,Kakihana T,Katsuragi Y,Onodera O,Iwakura Y,Nawa H,Komatsu M,Fujii M

Thu Mar 17 00:00:00 EDT 2022

USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance.

Molecular and cellular biology

Takahashi M,Kitaura H,Kakita A,Kakihana T,Katsuragi Y,Onodera O,Iwakura Y,Nawa H,Komatsu M,Fujii M

Thu Mar 17 00:00:00 EDT 2022

USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance.

Molecular and cellular biology

Takahashi M,Kitaura H,Kakita A,Kakihana T,Katsuragi Y,Onodera O,Iwakura Y,Nawa H,Komatsu M,Fujii M

Thu Mar 17 00:00:00 EDT 2022

USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance.

Molecular and cellular biology

Takahashi M,Kitaura H,Kakita A,Kakihana T,Katsuragi Y,Onodera O,Iwakura Y,Nawa H,Komatsu M,Fujii M

Thu Mar 17 00:00:00 EDT 2022

Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins.

Science translational medicine

Gao J,Mewborne QT,Girdhar A,Sheth U,Coyne AN,Punathil R,Kang BG,Dasovich M,Veire A,DeJesus Hernandez M,Liu S,Shi Z,Dafinca R,Fouquerel E,Talbot K,Kam TI,Zhang YJ,Dickson D,Petrucelli L,van Blitterswijk M,Guo L,Dawson TM,Dawson VL,Leung AKL,Lloyd TE,Gendron TF,Rothstein JD,Zhang K

Wed Sep 14 00:00:00 EDT 2022

Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration.

Science (New York, N.Y.)

Shao W,Todd TW,Wu Y,Jones CY,Tong J,Jansen-West K,Daughrity LM,Park J,Koike Y,Kurti A,Yue M,Castanedes-Casey M,Del Rosso G,Dunmore JA,Zanetti Alepuz D,Oskarsson B,Dickson DW,Cook CN,Prudencio M,Gendron TF,Fryer JD,Zhang YJ,Petrucelli L

Fri Oct 07 00:00:00 EDT 2022

Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis.

Science translational medicine

Britson KA,Ling JP,Braunstein KE,Montagne JM,Kastenschmidt JM,Wilson A,Ikenaga C,Tsao W,Pinal-Fernandez I,Russell KA,Reed N,Mozaffar T,Wagner KR,Ostrow LW,Corse AM,Mammen AL,Villalta SA,Larman HB,Wong PC,Lloyd TE

Wed Jan 19 00:00:00 EST 2022

Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition.

Nature cell biology

Lu S,Hu J,Arogundade OA,Goginashvili A,Vazquez-Sanchez S,Diedrich JK,Gu J,Blum J,Oung S,Ye Q,Yu H,Ravits J,Liu C,Yates JR,Cleveland DW

Thu Sep 01 00:00:00 EDT 2022

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation.

Cells

Lee S,Ryu HG,Kweon SH,Kim H,Park H,Lee KH,Jang SM,Na CH,Kim S,Ko HS

Thu Dec 08 00:00:00 EST 2022

Case of a Man with Hemichorea and Behavioral Changes: "A Red Herring".

Movement disorders clinical practice

Kleiner G,Ryan SA,Bilbao J,Keith J,Rogaeva E,Black SE,Lang AE,Masellis M

Sun May 01 00:00:00 EDT 2022

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43.

iScience

Kasu YAT,Arva A,Johnson J,Sajan C,Manzano J,Hennes A,Haynes J,Brower CS

Fri May 20 00:00:00 EDT 2022

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43.

iScience

Kasu YAT,Arva A,Johnson J,Sajan C,Manzano J,Hennes A,Haynes J,Brower CS

Fri May 20 00:00:00 EDT 2022

Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis.

Neuron

Zhang S,Cooper-Knock J,Weimer AK,Shi M,Moll T,Marshall JNG,Harvey C,Nezhad HG,Franklin J,Souza CDS,Ning K,Wang C,Li J,Dilliott AA,Farhan S,Elhaik E,Pasniceanu I,Livesey MR,Eitan C,Hornstein E,Kenna KP,Veldink JH,Ferraiuolo L,Shaw PJ,Snyder MP

Wed Mar 16 00:00:00 EDT 2022

Case Report: A Novel Splice-Site Mutation in DNAJB6 Associated With Juvenile-Onset Proximal-Distal Myopathy in a Chinese Patient.

Frontiers in genetics

Ji G,Wang N,Han X,Wang Y,Zhang J,Wu Y,Wu H,Ma S,Song X

Sat Jul 16 00:00:00 EDT 2022

TBK1 haploinsufficiency results in changes in the K63-ubiquitination profiles in brain and fibroblasts from affected and presymptomatic mutation carriers.

Journal of neurology

Khoshnood B,Ullgren A,Laffita-Mesa J,Öijerstedt L,Patra K,Nennesmo I,Graff C

Wed Jun 01 00:00:00 EDT 2022

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS.

Frontiers in neuroscience

Shenouda M,Xiao S,MacNair L,Lau A,Robertson J

Sat Jul 16 00:00:00 EDT 2022

Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.

Molecular neurobiology

Petrozziello T,Bordt EA,Mills AN,Kim SE,Sapp E,Devlin BA,Obeng-Marnu AA,Farhan SMK,Amaral AC,Dujardin S,Dooley PM,Henstridge C,Oakley DH,Neueder A,Hyman BT,Spires-Jones TL,Bilbo SD,Vakili K,Cudkowicz ME,Berry JD,DiFiglia M,Silva MC,Haggarty SJ,Sadri-Vakili G

Sat Jan 01 00:00:00 EST 2022

piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis.

Molecular neurobiology

Abdelhamid RF,Ogawa K,Beck G,Ikenaka K,Takeuchi E,Yasumizu Y,Jinno J,Kimura Y,Baba K,Nagai Y,Okada Y,Saito Y,Murayama S,Mochizuki H,Nagano S

Tue Mar 01 00:00:00 EST 2022

The kinase p38α functions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation.

Cellular & molecular immunology

Han M,Ma J,Ouyang S,Wang Y,Zheng T,Lu P,Zheng Z,Zhao W,Li H,Wu Y,Zhang B,Hu R,Otsu K,Liu X,Wan Y,Li H,Huang G

Fri Jul 01 00:00:00 EDT 2022

GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.

Neurobiology of disease

Bossolasco P,Cimini S,Maderna E,Bardelli D,Canafoglia L,Cavallaro T,Ricci M,Silani V,Marucci G,Rossi G

Thu Dec 01 00:00:00 EST 2022

GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.

Neurobiology of disease

Bossolasco P,Cimini S,Maderna E,Bardelli D,Canafoglia L,Cavallaro T,Ricci M,Silani V,Marucci G,Rossi G

Thu Dec 01 00:00:00 EST 2022

Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration.

Brain : a journal of neurology

Riku Y,Iwasaki Y,Ishigaki S,Akagi A,Hasegawa M,Nishioka K,Li Y,Riku M,Ikeuchi T,Fujioka Y,Miyahara H,Sone J,Hattori N,Yoshida M,Katsuno M,Sobue G

Sat Aug 27 00:00:00 EDT 2022

TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis.

JAMA neurology

Kurashige T,Morino H,Murao T,Izumi Y,Sugiura T,Kuraoka K,Kawakami H,Torii T,Maruyama H

Fri Jul 01 00:00:00 EDT 2022

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.

Nature communications

Gleixner AM,Verdone BM,Otte CG,Anderson EN,Ramesh N,Shapiro OR,Gale JR,Mauna JC,Mann JR,Copley KE,Daley EL,Ortega JA,Cicardi ME,Kiskinis E,Kofler J,Pandey UB,Trotti D,Donnelly CJ

Mon Jun 13 00:00:00 EDT 2022

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.

Nature

Brown AL,Wilkins OG,Keuss MJ,Hill SE,Zanovello M,Lee WC,Bampton A,Lee FCY,Masino L,Qi YA,Bryce-Smith S,Gatt A,Hallegger M,Fagegaltier D,Phatnani H,Newcombe J,Gustavsson EK,Seddighi S,Reyes JF,Coon SL,Ramos D,Schiavo G,Fisher EMC,Raj T,Secrier M,Lashley T,Ule J,Buratti E,Humphrey J,Ward ME,Fratta P

Tue Mar 01 00:00:00 EST 2022

Muscle and skin fibroblast TDP-43 expression, dynamic mutation analysis of NOTCH2NLC and C9orf72 in patients with FOSMN.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Liu Z,Guo X,Guo H,Luo J,Xiao F

Tue Nov 01 00:00:00 EDT 2022

Hyperphosphorylation-Mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage.

ACS chemical neuroscience

Chiang WC,Fang YS,Lye YS,Weng TY,Ganesan K,Huang SH,Chang LY,Chou SC,Chen YR

Wed Sep 07 00:00:00 EDT 2022

TDP-35, a truncated fragment of TDP-43, induces dose-dependent toxicity and apoptosis in flies.

Neural regeneration research

Chhangani D,Rincon-Limas DE

Tue Nov 01 00:00:00 EDT 2022

Apolipoprotein B-100-mediated motor neuron degeneration in sporadic amyotrophic lateral sclerosis.

Brain communications

Wong JK,Roselle AK,Shue TM,Shimshak SJE,Beaty JM,Celestin NM,Gao I,Griffin RP,Cudkowicz ME,Sadiq SA

Tue Sep 06 00:00:00 EDT 2022

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP.

Acta neuropathologica communications

Pickles S,Gendron TF,Koike Y,Yue M,Song Y,Kachergus JM,Shi J,DeTure M,Thompson EA,Oskarsson B,Graff-Radford NR,Boeve BF,Petersen RC,Wszolek ZK,Josephs KA,Dickson DW,Petrucelli L,Cook CN,Prudencio M

Mon Jul 25 00:00:00 EDT 2022

Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.

Brain communications

Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C

Thu Feb 09 00:00:00 EST 2023

Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.

Brain communications

Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C

Thu Feb 09 00:00:00 EST 2023

Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.

Brain communications

Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C

Thu Feb 09 00:00:00 EST 2023

Allele-specific silencing as therapy for familial amyotrophic lateral sclerosis caused by the p.G376D TARDBP mutation.

Brain communications

Romano R,De Luca M,Del Fiore VS,Pecoraro M,Lattante S,Sabatelli M,La Bella V,Bucci C

Thu Feb 09 00:00:00 EST 2023

Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old.

Acta neuropathologica

Wang SJ,Guo Y,Ervin JF,Lusk JB,Luo S

Fri Jul 01 00:00:00 EDT 2022

Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.

International journal of molecular sciences

Prtenjaca N,Rob M,Alam MS,Markovinovic A,Stuani C,Buratti E,Munitic I

Sun Jun 19 00:00:00 EDT 2022

Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels.

International journal of molecular sciences

Prtenjaca N,Rob M,Alam MS,Markovinovic A,Stuani C,Buratti E,Munitic I

Sun Jun 19 00:00:00 EDT 2022

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.

Acta neuropathologica communications

Feng T,Luan L,Katz II,Ullah M,Van Deerlin VM,Trojanowski JQ,Lee EB,Hu F

Mon Mar 14 00:00:00 EDT 2022

TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss.

Acta neuropathologica communications

Feng T,Luan L,Katz II,Ullah M,Van Deerlin VM,Trojanowski JQ,Lee EB,Hu F

Mon Mar 14 00:00:00 EDT 2022

Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.

The EMBO journal

Gruijs da Silva LA,Simonetti F,Hutten S,Riemenschneider H,Sternburg EL,Pietrek LM,Gebel J,Dötsch V,Edbauer D,Hummer G,Stelzl LS,Dormann D

Tue Apr 19 00:00:00 EDT 2022

TDP-43 Toxicity in Yeast Is Associated with a Reduction in Autophagy, and Deletions of TIP41 and PBP1 Counteract These Effects.

Viruses

Park SK,Park S,Liebman SW

Sat Oct 15 00:00:00 EDT 2022

TDP-43 is essential for Eph receptor-class-specific spinal motor axon trajectory into the limb.

Neuroscience research

Kao TJ,Wang CY,Hsu TI,Wu YH,Chuang JY,Huang CC,Hsieh CT

Tue Mar 01 00:00:00 EST 2022

A case of Lewy body disease and anaplastic astrocytoma presenting with atypical parkinsonism.

Neuropathology : official journal of the Japanese Society of Neuropathology

Leahy CB,Robinson AC,Jabbari E,Morris HR,Lally I,Djoukhadar I,Roncaroli F,Kobylecki C

Thu Dec 01 00:00:00 EST 2022

Cell environment shapes TDP-43 function with implications in neuronal and muscle disease.

Communications biology

Šušnjar U,Škrabar N,Brown AL,Abbassi Y,Phatnani H,Cortese A,Cereda C,Bugiardini E,Cardani R,Meola G,Ripolone M,Moggio M,Romano M,Secrier M,Fratta P,Buratti E

Tue Apr 05 00:00:00 EDT 2022

Frontotemporal Lobar Degeneration Case with an N-Terminal TUBA4A Mutation Exhibits Reduced TUBA4A Levels in the Brain and TDP-43 Pathology.

Biomolecules

Van Schoor E,Vandenbulcke M,Bercier V,Vandenberghe R,van der Zee J,Van Broeckhoven C,Otto M,Hanseeuw B,Van Damme P,Van Den Bosch L,Thal DR

Sat Mar 12 00:00:00 EST 2022

TDP-43 is a ubiquitylation substrate of the SCF^{cyclin F} complex.

Neurobiology of disease

Rayner SL,Yang S,Farrawell NE,Jagaraj CJ,Cheng F,Davidson JM,Luu L,Redondo AG,Rábano A,Borrego-Hernández D,Atkin JD,Morsch M,Blair IP,Yerbury JJ,Chung R,Lee A

Wed Jun 01 00:00:00 EDT 2022

Stress induced TDP-43 mobility loss independent of stress granules.

Nature communications

Streit L,Kuhn T,Vomhof T,Bopp V,Ludolph AC,Weishaupt JH,Gebhardt JCM,Michaelis J,Danzer KM

Mon Sep 19 00:00:00 EDT 2022

Stress induced TDP-43 mobility loss independent of stress granules.

Nature communications

Streit L,Kuhn T,Vomhof T,Bopp V,Ludolph AC,Weishaupt JH,Gebhardt JCM,Michaelis J,Danzer KM

Mon Sep 19 00:00:00 EDT 2022

Sertoli cells require TDP-43 to support spermatogenesis†.

Biology of reproduction

Zomer HD,Osuru HP,Chebolu A,Rayl JM,Timken M,Reddi PP

Mon Nov 14 00:00:00 EST 2022

TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients.

Cells

Rubio MA,Herrando-Grabulosa M,Velasco R,Blasco I,Povedano M,Navarro X

Sat Jan 08 00:00:00 EST 2022

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

The Journal of cell biology

Ho WY,Chang JC,Lim K,Cazenave-Gassiot A,Nguyen AT,Foo JC,Muralidharan S,Viera-Ortiz A,Ong SJM,Hor JH,Agrawal I,Hoon S,Arogundade OA,Rodriguez MJ,Lim SM,Kim SH,Ravits J,Ng SY,Wenk MR,Lee EB,Tucker-Kellogg G,Ling SC

Mon Sep 06 00:00:00 EDT 2021

Selection and Modelling of a New Single-Domain Intrabody Against TDP-43.

Frontiers in molecular biosciences

Gilodi M,Lisi S,F Dudás E,Fantini M,Puglisi R,Louka A,Marcatili P,Cattaneo A,Pastore A

Fri Mar 04 00:00:00 EST 2022

Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model.

Biochimica et biophysica acta. Molecular basis of disease

Smeltzer S,Quadri Z,Miller A,Zamudio F,Hunter J,Stewart NJF,Saji S,Lee DC,Chaput D,Selenica MB

Fri Jan 01 00:00:00 EST 2021

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.

International journal of molecular sciences

Deshimaru M,Kinoshita-Kawada M,Kubota K,Watanabe T,Tanaka Y,Hirano S,Ishidate F,Hiramoto M,Ishikawa M,Uehara Y,Okano H,Hirose S,Fujioka S,Iwasaki K,Yuasa-Kawada J,Mishima T,Tsuboi Y

Tue Apr 13 00:00:00 EDT 2021

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.

International journal of molecular sciences

Deshimaru M,Kinoshita-Kawada M,Kubota K,Watanabe T,Tanaka Y,Hirano S,Ishidate F,Hiramoto M,Ishikawa M,Uehara Y,Okano H,Hirose S,Fujioka S,Iwasaki K,Yuasa-Kawada J,Mishima T,Tsuboi Y

Tue Apr 13 00:00:00 EDT 2021

Parkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency.

Frontiers in molecular neuroscience

Gaweda-Walerych K,Walerych D,Berdyński M,Buratti E,Zekanowski C

Tue Jun 01 00:00:00 EDT 2021

An immune response characterizes early Alzheimer's disease pathology and subjective cognitive impairment in hydrocephalus biopsies.

Nature communications

Huang W,Bartosch AM,Xiao H,Maji S,Youth EHH,Flowers X,Leskinen S,Tomljanovic Z,Iodice G,Boyett D,Spinazzi E,Menon V,McGovern RA,McKhann GM,Teich AF

Mon Sep 27 00:00:00 EDT 2021

Communications biology

Koike Y,Sugai A,Hara N,Ito J,Yokoseki A,Ishihara T,Yamagishi T,Tsuboguchi S,Tada M,Ikeuchi T,Kakita A,Onodera O

Tue Sep 21 00:00:00 EDT 2021

Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death.

International journal of molecular sciences

Zhao Y,Tang F,Lee D,Xiong WC

Wed Aug 04 00:00:00 EDT 2021

Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction.

Antioxidants (Basel, Switzerland)

Jeon YM,Kwon Y,Lee S,Kim S,Jo M,Lee S,Kim SR,Kim K,Kim HJ

Wed Dec 29 00:00:00 EST 2021

Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction.

Antioxidants (Basel, Switzerland)

Jeon YM,Kwon Y,Lee S,Kim S,Jo M,Lee S,Kim SR,Kim K,Kim HJ

Wed Dec 29 00:00:00 EST 2021

The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43.

iScience

Kakihana T,Takahashi M,Katsuragi Y,Yamashita SI,Sango J,Kanki T,Onodera O,Fujii M

Fri Jul 23 00:00:00 EDT 2021

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells.

Science (New York, N.Y.)

Yu H,Lu S,Gasior K,Singh D,Vazquez-Sanchez S,Tapia O,Toprani D,Beccari MS,Yates JR,Da Cruz S,Newby JM,Lafarga M,Gladfelter AS,Villa E,Cleveland DW

Fri Feb 05 00:00:00 EST 2021

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells.

Science (New York, N.Y.)

Yu H,Lu S,Gasior K,Singh D,Vazquez-Sanchez S,Tapia O,Toprani D,Beccari MS,Yates JR,Da Cruz S,Newby JM,Lafarga M,Gladfelter AS,Villa E,Cleveland DW

Fri Feb 05 00:00:00 EST 2021

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.

Brain : a journal of neurology

Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V

Fri Dec 31 00:00:00 EST 2021

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.

Brain : a journal of neurology

Pasetto L,Grassano M,Pozzi S,Luotti S,Sammali E,Migazzi A,Basso M,Spagnolli G,Biasini E,Micotti E,Cerovic M,Carli M,Forloni G,De Marco G,Manera U,Moglia C,Mora G,Traynor BJ,Chiò A,Calvo A,Bonetto V

Fri Dec 31 00:00:00 EST 2021

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis.

Molecular neurodegeneration

Pasetto L,Callegaro S,Corbelli A,Fiordaliso F,Ferrara D,Brunelli L,Sestito G,Pastorelli R,Bianchi E,Cretich M,Chiari M,Potrich C,Moglia C,Corbo M,Sorarù G,Lunetta C,Calvo A,Chiò A,Mora G,Pennuto M,Quattrone A,Rinaldi F,D'Agostino VG,Basso M,Bonetto V

Tue Aug 10 00:00:00 EDT 2021

Interaction of tau with HNRNPA2B1 and N⁶-methyladenosine RNA mediates the progression of tauopathy.

Molecular cell

Jiang L,Lin W,Zhang C,Ash PEA,Verma M,Kwan J,van Vliet E,Yang Z,Cruz AL,Boudeau S,Maziuk BF,Lei S,Song J,Alvarez VE,Hovde S,Abisambra JF,Kuo MH,Kanaan N,Murray ME,Crary JF,Zhao J,Cheng JX,Petrucelli L,Li H,Emili A,Wolozin B

Thu Oct 21 00:00:00 EDT 2021

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lin NH,Yang AW,Chang CH,Perng MD

Sat May 01 00:00:00 EDT 2021

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lin NH,Yang AW,Chang CH,Perng MD

Sat May 01 00:00:00 EDT 2021

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS.

Nature structural & molecular biology

Zuo X,Zhou J,Li Y,Wu K,Chen Z,Luo Z,Zhang X,Liang Y,Esteban MA,Zhou Y,Fu XD

Mon Feb 01 00:00:00 EST 2021

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization.

Acta neuropathologica communications

Aladesuyi Arogundade O,Nguyen S,Leung R,Wainio D,Rodriguez M,Ravits J

Mon Feb 15 00:00:00 EST 2021

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Brain communications

Harley J,Hagemann C,Serio A,Patani R

Wed Mar 23 00:00:00 EDT 2022

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.

Brain communications

Harley J,Hagemann C,Serio A,Patani R

Wed Mar 23 00:00:00 EDT 2022

O-GlcNAcylation of TDP-43 suppresses proteinopathies and promotes TDP-43's mRNA splicing activity.

EMBO reports

Zhao MJ,Yao X,Wei P,Zhao C,Cheng M,Zhang D,Xue W,He WT,Xue W,Zuo X,Jiang LL,Luo Z,Song J,Shu WJ,Yuan HY,Liang Y,Sun H,Zhou Y,Zhou Y,Zheng L,Hu HY,Wang J,Du HN

Fri Jun 04 00:00:00 EDT 2021

Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis.

Acta neuropathologica

Diaz-Garcia S,Ko VI,Vazquez-Sanchez S,Chia R,Arogundade OA,Rodriguez MJ,Traynor BJ,Cleveland D,Ravits J

Wed Dec 01 00:00:00 EST 2021

Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis.

Nature medicine

Mohassel P,Donkervoort S,Lone MA,Nalls M,Gable K,Gupta SD,Foley AR,Hu Y,Saute JAM,Moreira AL,Kok F,Introna A,Logroscino G,Grunseich C,Nickolls AR,Pourshafie N,Neuhaus SB,Saade D,Gangfuß A,Kölbel H,Piccus Z,Le Pichon CE,Fiorillo C,Ly CV,Töpf A,Brady L,Specht S,Zidell A,Pedro H,Mittelmann E,Thomas FP,Chao KR,Konersman CG,Cho MT,Brandt T,Straub V,Connolly AM,Schara U,Roos A,Tarnopolsky M,Höke A,Brown RH,Lee CH,Hornemann T,Dunn TM,Bönnemann CG

Thu Jul 01 00:00:00 EDT 2021

Detection and quantification of novel C-terminal TDP-43 fragments in ALS-TDP.

Brain pathology (Zurich, Switzerland)

Feneberg E,Charles PD,Finelli MJ,Scott C,Kessler BM,Fischer R,Ansorge O,Gray E,Talbot K,Turner MR

Thu Jul 01 00:00:00 EDT 2021

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate.

The Journal of cell biology

Freibaum BD,Messing J,Yang P,Kim HJ,Taylor JP

Mon Mar 01 00:00:00 EST 2021

m⁶A Modified Short RNA Fragments Inhibit Cytoplasmic TLS/FUS Aggregation Induced by Hyperosmotic Stress.

International journal of molecular sciences

Yoneda R,Ueda N,Kurokawa R

Tue Oct 12 00:00:00 EDT 2021

Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.

The EMBO journal

Khosravi B,LaClair KD,Riemenschneider H,Zhou Q,Frottin F,Mareljic N,Czuppa M,Farny D,Hartmann H,Michaelsen M,Arzberger T,Hartl FU,Hipp MS,Edbauer D

Wed Apr 15 00:00:00 EDT 2020

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.

Autophagy

Deng Z,Lim J,Wang Q,Purtell K,Wu S,Palomo GM,Tan H,Manfredi G,Zhao Y,Peng J,Hu B,Chen S,Yue Z

Fri May 01 00:00:00 EDT 2020

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.

Autophagy

Deng Z,Lim J,Wang Q,Purtell K,Wu S,Palomo GM,Tan H,Manfredi G,Zhao Y,Peng J,Hu B,Chen S,Yue Z

Fri May 01 00:00:00 EDT 2020

Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons.

Cell death and differentiation

Tang FL,Zhao L,Zhao Y,Sun D,Zhu XJ,Mei L,Xiong WC

Wed Jul 01 00:00:00 EDT 2020

Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons.

Cell death and differentiation

Tang FL,Zhao L,Zhao Y,Sun D,Zhu XJ,Mei L,Xiong WC

Wed Jul 01 00:00:00 EDT 2020

Stress-Specific Spatiotemporal Responses of RNA-Binding Proteins in Human Stem-Cell-Derived Motor Neurons.

International journal of molecular sciences

Harley J,Patani R

Fri Nov 06 00:00:00 EST 2020

Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.

Proceedings of the National Academy of Sciences of the United States of America

Peng AYT,Agrawal I,Ho WY,Yen YC,Pinter AJ,Liu J,Phua QXC,Koh KB,Chang JC,Sanford E,Man JHK,Wong P,Gutmann DH,Tucker-Kellogg G,Ling SC

Tue Nov 17 00:00:00 EST 2020

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.

Acta neuropathologica

LaClair KD,Zhou Q,Michaelsen M,Wefers B,Brill MS,Janjic A,Rathkolb B,Farny D,Cygan M,de Angelis MH,Wurst W,Neumann M,Enard W,Misgeld T,Arzberger T,Edbauer D

Sat Aug 01 00:00:00 EDT 2020

BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.

Cell systems

Pourhaghighi R,Ash PEA,Phanse S,Goebels F,Hu LZM,Chen S,Zhang Y,Wierbowski SD,Boudeau S,Moutaoufik MT,Malty RH,Malolepsza E,Tsafou K,Nathan A,Cromar G,Guo H,Abdullatif AA,Apicco DJ,Becker LA,Gitler AD,Pulst SM,Youssef A,Hekman R,Havugimana PC,White CA,Blum BC,Ratti A,Bryant CD,Parkinson J,Lage K,Babu M,Yu H,Bader GD,Wolozin B,Emili A

Wed Apr 22 00:00:00 EDT 2020

TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.

Nature communications

Shih YH,Tu LH,Chang TY,Ganesan K,Chang WW,Chang PS,Fang YS,Lin YT,Jin LW,Chen YR

Mon Nov 23 00:00:00 EST 2020

TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles.

BMC biology

Strah N,Romano G,Introna C,Klima R,Marzullo M,Ciapponi L,Megighian A,Nizzardo M,Feiguin F

Thu Mar 26 00:00:00 EDT 2020

Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons.

JCI insight

Pozzi S,Codron P,Soucy G,Renaud L,Cordeau PJ,Dutta K,Bareil C,Julien JP

Thu Nov 05 00:00:00 EST 2020

Cytoplasmic localization of amyotrophic lateral sclerosis-related TDP-43 proteins modulates stress granule formation.

The European journal of neuroscience

Besnard-Guérin C

Thu Oct 01 00:00:00 EDT 2020

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1.

Science advances

Barra J,Gaidosh GS,Blumenthal E,Beckedorff F,Tayari MM,Kirstein N,Karakach TK,Jensen TH,Impens F,Gevaert K,Leucci E,Shiekhattar R,Marine JC

Wed Jul 01 00:00:00 EDT 2020

Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS.

Neurobiology of disease

Bourefis AR,Campanari ML,Buee-Scherrer V,Kabashi E

Sat Aug 01 00:00:00 EDT 2020

TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity.

BMC biology

Romano G,Klima R,Feiguin F

Fri Jul 03 00:00:00 EDT 2020

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.

The Journal of clinical investigation

Prudencio M,Humphrey J,Pickles S,Brown AL,Hill SE,Kachergus JM,Shi J,Heckman MG,Spiegel MR,Cook C,Song Y,Yue M,Daughrity LM,Carlomagno Y,Jansen-West K,de Castro CF,DeTure M,Koga S,Wang YC,Sivakumar P,Bodo C,Candalija A,Talbot K,Selvaraj BT,Burr K,Chandran S,Newcombe J,Lashley T,Hubbard I,Catalano D,Kim D,Propp N,Fennessey S,Fagegaltier D,Phatnani H,Secrier M,Fisher EM,Oskarsson B,van Blitterswijk M,Rademakers R,Graff-Radford NR,Boeve BF,Knopman DS,Petersen RC,Josephs KA,Thompson EA,Raj T,Ward M,Dickson DW,Gendron TF,Fratta P,Petrucelli L

Mon Nov 02 00:00:00 EST 2020

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.

The Journal of clinical investigation

Mon Nov 02 00:00:00 EST 2020

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

EMBO reports

Werner G,Damme M,Schludi M,Gnörich J,Wind K,Fellerer K,Wefers B,Wurst W,Edbauer D,Brendel M,Haass C,Capell A

Mon Oct 05 00:00:00 EDT 2020

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

EMBO reports

Werner G,Damme M,Schludi M,Gnörich J,Wind K,Fellerer K,Wefers B,Wurst W,Edbauer D,Brendel M,Haass C,Capell A

Mon Oct 05 00:00:00 EDT 2020

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization.

Brain communications

Tazelaar GHP,Boeynaems S,De Decker M,van Vugt JJFA,Kool L,Goedee HS,McLaughlin RL,Sproviero W,Iacoangeli A,Moisse M,Jacquemyn M,Daelemans D,Dekker AM,van der Spek RA,Westeneng HJ,Kenna KP,Assialioui A,Da Silva N,Povedano M,Pardina JSM,Hardiman O,Salachas F,Millecamps S,Vourc'h P,Corcia P,Couratier P,Morrison KE,Shaw PJ,Shaw CE,Pasterkamp RJ,Landers JE,Van Den Bosch L,Robberecht W,Al-Chalabi A,van den Berg LH,Van Damme P,Veldink JH,van Es MA

Tue Jan 31 00:00:00 EST 2023

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization.

Brain communications

Tue Jan 31 00:00:00 EST 2023

Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants.

BMC neuroscience

Venkataraman L,He P,Khan G,Harris BT,Sierks MR

Fri Sep 04 00:00:00 EDT 2020

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.

Molecular cell

Wang B,Maxwell BA,Joo JH,Gwon Y,Messing J,Mishra A,Shaw TI,Ward AL,Quan H,Sakurada SM,Pruett-Miller SM,Bertorini T,Vogel P,Kim HJ,Peng J,Taylor JP,Kundu M

Thu May 16 00:00:00 EDT 2019

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.

Neuron

Gasset-Rosa F,Lu S,Yu H,Chen C,Melamed Z,Guo L,Shorter J,Da Cruz S,Cleveland DW

Wed Apr 17 00:00:00 EDT 2019

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.

Neuron

Gasset-Rosa F,Lu S,Yu H,Chen C,Melamed Z,Guo L,Shorter J,Da Cruz S,Cleveland DW

Wed Apr 17 00:00:00 EDT 2019

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Neuron

Mann JR,Gleixner AM,Mauna JC,Gomes E,DeChellis-Marks MR,Needham PG,Copley KE,Hurtle B,Portz B,Pyles NJ,Guo L,Calder CB,Wills ZP,Pandey UB,Kofler JK,Brodsky JL,Thathiah A,Shorter J,Donnelly CJ

Wed Apr 17 00:00:00 EDT 2019

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.

Molecular neurobiology

Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ

Fri Mar 01 00:00:00 EST 2019

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.

Molecular neurobiology

Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ

Fri Mar 01 00:00:00 EST 2019

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.

Molecular neurobiology

Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ

Fri Mar 01 00:00:00 EST 2019

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.

Molecular neurobiology

Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ

Fri Mar 01 00:00:00 EST 2019

Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.

Molecular neurobiology

Jeon GS,Shim YM,Lee DY,Kim JS,Kang M,Ahn SH,Shin JY,Geum D,Hong YH,Sung JJ

Fri Mar 01 00:00:00 EST 2019

Development of an automated capillary nano-immunoassay-Simple Western assay-to quantify total TDP43 protein in human platelet samples.

Analytical and bioanalytical chemistry

Fourier A,Escal J,Bernard E,Lachman I,Perret-Liaudet A,Leblanc P,Quadrio I

Tue Jan 01 00:00:00 EST 2019

Development of an automated capillary nano-immunoassay-Simple Western assay-to quantify total TDP43 protein in human platelet samples.

Analytical and bioanalytical chemistry

Fourier A,Escal J,Bernard E,Lachman I,Perret-Liaudet A,Leblanc P,Quadrio I

Tue Jan 01 00:00:00 EST 2019

Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology.

Toxicological sciences : an official journal of the Society of Toxicology

Ash PEA,Dhawan U,Boudeau S,Lei S,Carlomagno Y,Knobel M,Al Mohanna LFA,Boomhower SR,Newland MC,Sherr DH,Wolozin B

Tue Jan 01 00:00:00 EST 2019

Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology.

Toxicological sciences : an official journal of the Society of Toxicology

Ash PEA,Dhawan U,Boudeau S,Lei S,Carlomagno Y,Knobel M,Al Mohanna LFA,Boomhower SR,Newland MC,Sherr DH,Wolozin B

Tue Jan 01 00:00:00 EST 2019

Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology.

Toxicological sciences : an official journal of the Society of Toxicology

Ash PEA,Dhawan U,Boudeau S,Lei S,Carlomagno Y,Knobel M,Al Mohanna LFA,Boomhower SR,Newland MC,Sherr DH,Wolozin B

Tue Jan 01 00:00:00 EST 2019

Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology.

Toxicological sciences : an official journal of the Society of Toxicology

Ash PEA,Dhawan U,Boudeau S,Lei S,Carlomagno Y,Knobel M,Al Mohanna LFA,Boomhower SR,Newland MC,Sherr DH,Wolozin B

Tue Jan 01 00:00:00 EST 2019

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Science (New York, N.Y.)

Zhang YJ,Guo L,Gonzales PK,Gendron TF,Wu Y,Jansen-West K,O'Raw AD,Pickles SR,Prudencio M,Carlomagno Y,Gachechiladze MA,Ludwig C,Tian R,Chew J,DeTure M,Lin WL,Tong J,Daughrity LM,Yue M,Song Y,Andersen JW,Castanedes-Casey M,Kurti A,Datta A,Antognetti G,McCampbell A,Rademakers R,Oskarsson B,Dickson DW,Kampmann M,Ward ME,Fryer JD,Link CD,Shorter J,Petrucelli L

Fri Feb 15 00:00:00 EST 2019

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Science (New York, N.Y.)

Fri Feb 15 00:00:00 EST 2019

C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation.

Cell death & disease

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Thu Oct 03 00:00:00 EDT 2019

C9-ALS/FTD-linked proline-arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation.

Cell death & disease

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Thu Oct 03 00:00:00 EDT 2019

Increased Lysosomal Exocytosis Induced by Lysosomal Ca²⁺ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Tsunemi T,Perez-Rosello T,Ishiguro Y,Yoroisaka A,Jeon S,Hamada K,Rammonhan M,Wong YC,Xie Z,Akamatsu W,Mazzulli JR,Surmeier DJ,Hattori N,Krainc D

Wed Jul 17 00:00:00 EDT 2019

Splicing repression is a major function of TDP-43 in motor neurons.

Acta neuropathologica

Donde A,Sun M,Ling JP,Braunstein KE,Pang B,Wen X,Cheng X,Chen L,Wong PC

Fri Nov 01 00:00:00 EDT 2019

TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis.

Cells

Lanznaster D,Bourgeais J,Bruno C,Hergesheimer RC,Thepault RA,Vourc'h P,Corcia P,Andres CR,Herault O,Blasco H

Thu Dec 26 00:00:00 EST 2019

TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.

PLoS pathogens

Masaki K,Sonobe Y,Ghadge G,Pytel P,Roos RP

Fri Feb 01 00:00:00 EST 2019

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology.

eLife

Zhang P,Fan B,Yang P,Temirov J,Messing J,Kim HJ,Taylor JP

Wed Mar 20 00:00:00 EDT 2019

Phosphorylated and aggregated TDP-43 with seeding properties are induced upon mutant Huntingtin (mHtt) polyglutamine expression in human cellular models.

Cellular and molecular life sciences : CMLS

Coudert L,Nonaka T,Bernard E,Hasegawa M,Schaeffer L,Leblanc P

Mon Jul 01 00:00:00 EDT 2019

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD.

Nature communications

Yuva-Aydemir Y,Almeida S,Krishnan G,Gendron TF,Gao FB

Fri Nov 29 00:00:00 EST 2019

TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1.

Cell reports

Chu JF,Majumder P,Chatterjee B,Huang SL,Shen CJ

Tue Dec 03 00:00:00 EST 2019

TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1.

Cell reports

Chu JF,Majumder P,Chatterjee B,Huang SL,Shen CJ

Tue Dec 03 00:00:00 EST 2019

C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.

Nature neuroscience

Choi SY,Lopez-Gonzalez R,Krishnan G,Phillips HL,Li AN,Seeley WW,Yao WD,Almeida S,Gao FB

Sat Jun 01 00:00:00 EDT 2019

Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation.

Neurobiology of disease

Sugai A,Kato T,Koyama A,Koike Y,Konno T,Ishihara T,Onodera O

Tue Oct 01 00:00:00 EDT 2019

Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation.

Neurobiology of disease

Sugai A,Kato T,Koyama A,Koike Y,Konno T,Ishihara T,Onodera O

Tue Oct 01 00:00:00 EDT 2019

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Nature

Vogler TO,Wheeler JR,Nguyen ED,Hughes MP,Britson KA,Lester E,Rao B,Betta ND,Whitney ON,Ewachiw TE,Gomes E,Shorter J,Lloyd TE,Eisenberg DS,Taylor JP,Johnson AM,Olwin BB,Parker R

Thu Nov 01 00:00:00 EDT 2018

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Nature

Vogler TO,Wheeler JR,Nguyen ED,Hughes MP,Britson KA,Lester E,Rao B,Betta ND,Whitney ON,Ewachiw TE,Gomes E,Shorter J,Lloyd TE,Eisenberg DS,Taylor JP,Johnson AM,Olwin BB,Parker R

Thu Nov 01 00:00:00 EDT 2018

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Nature

Vogler TO,Wheeler JR,Nguyen ED,Hughes MP,Britson KA,Lester E,Rao B,Betta ND,Whitney ON,Ewachiw TE,Gomes E,Shorter J,Lloyd TE,Eisenberg DS,Taylor JP,Johnson AM,Olwin BB,Parker R

Thu Nov 01 00:00:00 EDT 2018

Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells.

Journal of neurochemistry

Salvatori I,Ferri A,Scaricamazza S,Giovannelli I,Serrano A,Rossi S,D'Ambrosi N,Cozzolino M,Giulio AD,Moreno S,Valle C,Carrì MT

Sat Sep 01 00:00:00 EDT 2018

Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells.

Journal of neurochemistry

Salvatori I,Ferri A,Scaricamazza S,Giovannelli I,Serrano A,Rossi S,D'Ambrosi N,Cozzolino M,Giulio AD,Moreno S,Valle C,Carrì MT

Sat Sep 01 00:00:00 EDT 2018

Microtubules as platforms for probing liquid-liquid phase separation in cells - application to RNA-binding proteins.

Journal of cell science

Maucuer A,Desforges B,Joshi V,Boca M,Kretov DA,Hamon L,Bouhss A,Curmi PA,Pastré D

Mon Jun 11 00:00:00 EDT 2018

Microtubules as platforms for probing liquid-liquid phase separation in cells - application to RNA-binding proteins.

Journal of cell science

Maucuer A,Desforges B,Joshi V,Boca M,Kretov DA,Hamon L,Bouhss A,Curmi PA,Pastré D

Mon Jun 11 00:00:00 EDT 2018

The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology.

Molecular and cellular biology

Kasu YAT,Alemu S,Lamari A,Loew N,Brower CS

Mon Oct 01 00:00:00 EDT 2018

The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology.

Molecular and cellular biology

Kasu YAT,Alemu S,Lamari A,Loew N,Brower CS

Mon Oct 01 00:00:00 EDT 2018

The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology.

Molecular and cellular biology

Kasu YAT,Alemu S,Lamari A,Loew N,Brower CS

Mon Oct 01 00:00:00 EDT 2018

The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology.

Molecular and cellular biology

Kasu YAT,Alemu S,Lamari A,Loew N,Brower CS

Mon Oct 01 00:00:00 EDT 2018

Diallyl Trisulfide Protects Motor Neurons from the Neurotoxic Protein TDP-43 via Activating Lysosomal Degradation and the Antioxidant Response.

Neurochemical research

Liu C,Leng B,Li Y,Jiang H,Duan W,Guo Y,Li C,Hong K

Sat Dec 01 00:00:00 EST 2018

Diallyl Trisulfide Protects Motor Neurons from the Neurotoxic Protein TDP-43 via Activating Lysosomal Degradation and the Antioxidant Response.

Neurochemical research

Liu C,Leng B,Li Y,Jiang H,Duan W,Guo Y,Li C,Hong K

Sat Dec 01 00:00:00 EST 2018

Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma.

Journal of cancer research and clinical oncology

Wang K,Qu X,Liu S,Yang X,Bie F,Wang Y,Huang C,Du J

Wed Aug 01 00:00:00 EDT 2018

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

Biochemical and biophysical research communications

Clemen CS,Winter L,Strucksberg KH,Berwanger C,Türk M,Kornblum C,Florin A,Aguilar-Pimentel JA,Amarie OV,Becker L,Garrett L,Hans W,Moreth K,Neff F,Pingen L,Rathkolb B,Rácz I,Rozman J,Treise I,Fuchs H,Gailus-Durner V,de Angelis MH,Vorgerd M,Eichinger L,Schröder R

Tue Sep 18 00:00:00 EDT 2018

The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

Biochemical and biophysical research communications

Tue Sep 18 00:00:00 EDT 2018

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells.

Scientific reports

Cicardi ME,Cristofani R,Rusmini P,Meroni M,Ferrari V,Vezzoli G,Tedesco B,Piccolella M,Messi E,Galbiati M,Boncoraglio A,Carra S,Crippa V,Poletti A

Fri Aug 17 00:00:00 EDT 2018

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells.

Scientific reports

Cicardi ME,Cristofani R,Rusmini P,Meroni M,Ferrari V,Vezzoli G,Tedesco B,Piccolella M,Messi E,Galbiati M,Boncoraglio A,Carra S,Crippa V,Poletti A

Fri Aug 17 00:00:00 EDT 2018

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells.

Scientific reports

Cicardi ME,Cristofani R,Rusmini P,Meroni M,Ferrari V,Vezzoli G,Tedesco B,Piccolella M,Messi E,Galbiati M,Boncoraglio A,Carra S,Crippa V,Poletti A

Fri Aug 17 00:00:00 EDT 2018

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells.

Scientific reports

Cicardi ME,Cristofani R,Rusmini P,Meroni M,Ferrari V,Vezzoli G,Tedesco B,Piccolella M,Messi E,Galbiati M,Boncoraglio A,Carra S,Crippa V,Poletti A

Fri Aug 17 00:00:00 EDT 2018

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

Journal of biomedical science

Lee YC,Huang WC,Lin JH,Kao TJ,Lin HC,Lee KH,Lin HC,Shen CJ,Chang WC,Huang CC

Thu Nov 08 00:00:00 EST 2018

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

Journal of biomedical science

Lee YC,Huang WC,Lin JH,Kao TJ,Lin HC,Lee KH,Lin HC,Shen CJ,Chang WC,Huang CC

Thu Nov 08 00:00:00 EST 2018

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

Journal of biomedical science

Lee YC,Huang WC,Lin JH,Kao TJ,Lin HC,Lee KH,Lin HC,Shen CJ,Chang WC,Huang CC

Thu Nov 08 00:00:00 EST 2018

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.

Journal of biomedical science

Lee YC,Huang WC,Lin JH,Kao TJ,Lin HC,Lee KH,Lin HC,Shen CJ,Chang WC,Huang CC

Thu Nov 08 00:00:00 EST 2018

The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis.

Cell death & disease

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Mon Sep 24 00:00:00 EDT 2018

The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis.

Cell death & disease

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Mon Sep 24 00:00:00 EDT 2018

Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.

Acta neuropathologica

Bennett CL,Dastidar SG,Ling SC,Malik B,Ashe T,Wadhwa M,Miller DB,Lee C,Mitchell MB,van Es MA,Grunseich C,Chen Y,Sopher BL,Greensmith L,Cleveland DW,La Spada AR

Sat Sep 01 00:00:00 EDT 2018

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.

Nature

Becker LA,Huang B,Bieri G,Ma R,Knowles DA,Jafar-Nejad P,Messing J,Kim HJ,Soriano A,Auburger G,Pulst SM,Taylor JP,Rigo F,Gitler AD

Thu Apr 20 00:00:00 EDT 2017

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.

Nature

Becker LA,Huang B,Bieri G,Ma R,Knowles DA,Jafar-Nejad P,Messing J,Kim HJ,Soriano A,Auburger G,Pulst SM,Taylor JP,Rigo F,Gitler AD

Thu Apr 20 00:00:00 EDT 2017

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.

Nature

Becker LA,Huang B,Bieri G,Ma R,Knowles DA,Jafar-Nejad P,Messing J,Kim HJ,Soriano A,Auburger G,Pulst SM,Taylor JP,Rigo F,Gitler AD

Thu Apr 20 00:00:00 EDT 2017

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.

Nature

Becker LA,Huang B,Bieri G,Ma R,Knowles DA,Jafar-Nejad P,Messing J,Kim HJ,Soriano A,Auburger G,Pulst SM,Taylor JP,Rigo F,Gitler AD

Thu Apr 20 00:00:00 EDT 2017

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.

Molecular cell

Boeynaems S,Bogaert E,Kovacs D,Konijnenberg A,Timmerman E,Volkov A,Guharoy M,De Decker M,Jaspers T,Ryan VH,Janke AM,Baatsen P,Vercruysse T,Kolaitis RM,Daelemans D,Taylor JP,Kedersha N,Anderson P,Impens F,Sobott F,Schymkowitz J,Rousseau F,Fawzi NL,Robberecht W,Van Damme P,Tompa P,Van Den Bosch L

Thu Mar 16 00:00:00 EDT 2017

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.

Molecular cell

Thu Mar 16 00:00:00 EDT 2017

TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice.

Brain, behavior, and immunity

Zhuang J,Wen X,Zhang YQ,Shan Q,Zhang ZF,Zheng GH,Fan SH,Li MQ,Wu DM,Hu B,Lu J,Zheng YL

Sun Oct 01 00:00:00 EDT 2017

TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice.

Brain, behavior, and immunity

Zhuang J,Wen X,Zhang YQ,Shan Q,Zhang ZF,Zheng GH,Fan SH,Li MQ,Wu DM,Hu B,Lu J,Zheng YL

Sun Oct 01 00:00:00 EDT 2017

TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice.

Brain, behavior, and immunity

Zhuang J,Wen X,Zhang YQ,Shan Q,Zhang ZF,Zheng GH,Fan SH,Li MQ,Wu DM,Hu B,Lu J,Zheng YL

Sun Oct 01 00:00:00 EDT 2017

TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice.

Brain, behavior, and immunity

Zhuang J,Wen X,Zhang YQ,Shan Q,Zhang ZF,Zheng GH,Fan SH,Li MQ,Wu DM,Hu B,Lu J,Zheng YL

Sun Oct 01 00:00:00 EDT 2017

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.

Neuron

Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,Mesulam M,Keith J,Zivkovic SA,Hirsch-Reinshagen V,Roos RP,Züchner S,Graff-Radford NR,Petersen RC,Caselli RJ,Wszolek ZK,Finger E,Lippa C,Lacomis D,Stewart H,Dickson DW,Kim HJ,Rogaeva E,Bigio E,Boylan KB,Taylor JP,Rademakers R

Wed Aug 16 00:00:00 EDT 2017

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.

Neuron

Wed Aug 16 00:00:00 EDT 2017

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.

Acta neuropathologica

Schludi MH,Becker L,Garrett L,Gendron TF,Zhou Q,Schreiber F,Popper B,Dimou L,Strom TM,Winkelmann J,von Thaden A,Rentzsch K,May S,Michaelsen M,Schwenk BM,Tan J,Schoser B,Dieterich M,Petrucelli L,Hölter SM,Wurst W,Fuchs H,Gailus-Durner V,de Angelis MH,Klopstock T,Arzberger T,Edbauer D

Tue Aug 01 00:00:00 EDT 2017

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.

Acta neuropathologica

Tue Aug 01 00:00:00 EDT 2017

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.

Acta neuropathologica

Ditsworth D,Maldonado M,McAlonis-Downes M,Sun S,Seelman A,Drenner K,Arnold E,Ling SC,Pizzo D,Ravits J,Cleveland DW,Da Cruz S

Thu Jun 01 00:00:00 EDT 2017

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis.

Acta neuropathologica

Ditsworth D,Maldonado M,McAlonis-Downes M,Sun S,Seelman A,Drenner K,Arnold E,Ling SC,Pizzo D,Ravits J,Cleveland DW,Da Cruz S

Thu Jun 01 00:00:00 EDT 2017

Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Leal-Lasarte MM,Franco JM,Labrador-Garrido A,Pozo D,Roodveldt C

Sat Jul 01 00:00:00 EDT 2017

Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Leal-Lasarte MM,Franco JM,Labrador-Garrido A,Pozo D,Roodveldt C

Sat Jul 01 00:00:00 EDT 2017

Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Leal-Lasarte MM,Franco JM,Labrador-Garrido A,Pozo D,Roodveldt C

Sat Jul 01 00:00:00 EDT 2017

Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Leal-Lasarte MM,Franco JM,Labrador-Garrido A,Pozo D,Roodveldt C

Sat Jul 01 00:00:00 EDT 2017

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.

Human molecular genetics

Prudencio M,Gonzales PK,Cook CN,Gendron TF,Daughrity LM,Song Y,Ebbert MTW,van Blitterswijk M,Zhang YJ,Jansen-West K,Baker MC,DeTure M,Rademakers R,Boylan KB,Dickson DW,Petrucelli L,Link CD

Fri Sep 01 00:00:00 EDT 2017

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.

Human molecular genetics

Prudencio M,Gonzales PK,Cook CN,Gendron TF,Daughrity LM,Song Y,Ebbert MTW,van Blitterswijk M,Zhang YJ,Jansen-West K,Baker MC,DeTure M,Rademakers R,Boylan KB,Dickson DW,Petrucelli L,Link CD

Fri Sep 01 00:00:00 EDT 2017

Immunolocalization of TAR DNA-binding protein of 43 kDa (TDP-43) in mouse seminiferous epithelium.

Molecular reproduction and development

Osuru HP,Pramoonjago P,Abhyankar MM,Swanson E,Roker LA,Cathro H,Reddi PP

Tue Aug 01 00:00:00 EDT 2017

Immunolocalization of TAR DNA-binding protein of 43 kDa (TDP-43) in mouse seminiferous epithelium.

Molecular reproduction and development

Osuru HP,Pramoonjago P,Abhyankar MM,Swanson E,Roker LA,Cathro H,Reddi PP

Tue Aug 01 00:00:00 EDT 2017

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.

Human molecular genetics

Valdez C,Wong YC,Schwake M,Bu G,Wszolek ZK,Krainc D

Fri Dec 15 00:00:00 EST 2017

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.

Human molecular genetics

Valdez C,Wong YC,Schwake M,Bu G,Wszolek ZK,Krainc D

Fri Dec 15 00:00:00 EST 2017

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.

Human molecular genetics

Hogan AL,Don EK,Rayner SL,Lee A,Laird AS,Watchon M,Winnick C,Tarr IS,Morsch M,Fifita JA,Gwee SSL,Formella I,Hortle E,Yuan KC,Molloy MP,Williams KL,Nicholson GA,Chung RS,Blair IP,Cole NJ

Sat Jul 15 00:00:00 EDT 2017

Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.

PloS one

Wobst HJ,Delsing L,Brandon NJ,Moss SJ

Wed Sep 06 00:00:00 EDT 2017

Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.

PloS one

Wobst HJ,Delsing L,Brandon NJ,Moss SJ

Wed Sep 06 00:00:00 EDT 2017

Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.

PloS one

Wobst HJ,Delsing L,Brandon NJ,Moss SJ

Wed Sep 06 00:00:00 EDT 2017

Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant.

PloS one

Wobst HJ,Delsing L,Brandon NJ,Moss SJ

Wed Sep 06 00:00:00 EDT 2017

Molecular neurodegeneration

Ash PEA,Stanford EA,Al Abdulatif A,Ramirez-Cardenas A,Ballance HI,Boudeau S,Jeh A,Murithi JM,Tripodis Y,Murphy GJ,Sherr DH,Wolozin B

Fri May 05 00:00:00 EDT 2017

Molecular neurodegeneration

Ash PEA,Stanford EA,Al Abdulatif A,Ramirez-Cardenas A,Ballance HI,Boudeau S,Jeh A,Murithi JM,Tripodis Y,Murphy GJ,Sherr DH,Wolozin B

Fri May 05 00:00:00 EDT 2017

Tdp-43 cryptic exons are highly variable between cell types.

Molecular neurodegeneration

Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC

Thu Feb 02 00:00:00 EST 2017

Tdp-43 cryptic exons are highly variable between cell types.

Molecular neurodegeneration

Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC

Thu Feb 02 00:00:00 EST 2017

Tdp-43 cryptic exons are highly variable between cell types.

Molecular neurodegeneration

Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC

Thu Feb 02 00:00:00 EST 2017

Tdp-43 cryptic exons are highly variable between cell types.

Molecular neurodegeneration

Jeong YH,Ling JP,Lin SZ,Donde AN,Braunstein KE,Majounie E,Traynor BJ,LaClair KD,Lloyd TE,Wong PC

Thu Feb 02 00:00:00 EST 2017

Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.

eLife

Celona B,Dollen JV,Vatsavayai SC,Kashima R,Johnson JR,Tang AA,Hata A,Miller BL,Huang EJ,Krogan NJ,Seeley WW,Black BL

Tue Jan 10 00:00:00 EST 2017

Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.

eLife

Celona B,Dollen JV,Vatsavayai SC,Kashima R,Johnson JR,Tang AA,Hata A,Miller BL,Huang EJ,Krogan NJ,Seeley WW,Black BL

Tue Jan 10 00:00:00 EST 2017

Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.

Acta neuropathologica

LaClair KD,Donde A,Ling JP,Jeong YH,Chhabra R,Martin LJ,Wong PC

Thu Dec 01 00:00:00 EST 2016

Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.

Acta neuropathologica

LaClair KD,Donde A,Ling JP,Jeong YH,Chhabra R,Martin LJ,Wong PC

Thu Dec 01 00:00:00 EST 2016

Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.

Brain : a journal of neurology

Shiihashi G,Ito D,Yagi T,Nihei Y,Ebine T,Suzuki N

Thu Sep 01 00:00:00 EDT 2016

Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.

Brain : a journal of neurology

Shiihashi G,Ito D,Yagi T,Nihei Y,Ebine T,Suzuki N

Thu Sep 01 00:00:00 EDT 2016

Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.

Brain : a journal of neurology

Shiihashi G,Ito D,Yagi T,Nihei Y,Ebine T,Suzuki N

Thu Sep 01 00:00:00 EDT 2016

Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.

Brain : a journal of neurology

Shiihashi G,Ito D,Yagi T,Nihei Y,Ebine T,Suzuki N

Thu Sep 01 00:00:00 EDT 2016

TDP-43 regulates endogenous retrovirus-K viral protein accumulation.

Neurobiology of disease

Manghera M,Ferguson-Parry J,Douville RN

Sat Oct 01 00:00:00 EDT 2016

TDP-43 regulates endogenous retrovirus-K viral protein accumulation.

Neurobiology of disease

Manghera M,Ferguson-Parry J,Douville RN

Sat Oct 01 00:00:00 EDT 2016

TDP-43 regulates endogenous retrovirus-K viral protein accumulation.

Neurobiology of disease

Manghera M,Ferguson-Parry J,Douville RN

Sat Oct 01 00:00:00 EDT 2016

TDP-43 regulates endogenous retrovirus-K viral protein accumulation.

Neurobiology of disease

Manghera M,Ferguson-Parry J,Douville RN

Sat Oct 01 00:00:00 EDT 2016

The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.

The American journal of pathology

Rodriguez-Ortiz CJ,Flores JC,Valenzuela JA,Rodriguez GJ,Zumkehr J,Tran DN,Kimonis VE,Kitazawa M

Wed Jun 01 00:00:00 EDT 2016

The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.

The American journal of pathology

Rodriguez-Ortiz CJ,Flores JC,Valenzuela JA,Rodriguez GJ,Zumkehr J,Tran DN,Kimonis VE,Kitazawa M

Wed Jun 01 00:00:00 EDT 2016

The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.

The American journal of pathology

Rodriguez-Ortiz CJ,Flores JC,Valenzuela JA,Rodriguez GJ,Zumkehr J,Tran DN,Kimonis VE,Kitazawa M

Wed Jun 01 00:00:00 EDT 2016

The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.

The American journal of pathology

Rodriguez-Ortiz CJ,Flores JC,Valenzuela JA,Rodriguez GJ,Zumkehr J,Tran DN,Kimonis VE,Kitazawa M

Wed Jun 01 00:00:00 EDT 2016

The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.

The Journal of biological chemistry

Suzuki H,Matsuoka M

Fri Oct 07 00:00:00 EDT 2016

The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.

The Journal of biological chemistry

Suzuki H,Matsuoka M

Fri Oct 07 00:00:00 EDT 2016

Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function.

Human molecular genetics

Orrù S,Coni P,Floris A,Littera R,Carcassi C,Sogos V,Brancia C

Sat Oct 15 00:00:00 EDT 2016

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Human molecular genetics

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Sun Mar 15 00:00:00 EDT 2015

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Human molecular genetics

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Sun Mar 15 00:00:00 EDT 2015

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Human molecular genetics

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Sun Mar 15 00:00:00 EDT 2015

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Human molecular genetics

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Sun Mar 15 00:00:00 EDT 2015

PABPN1 suppresses TDP-43 toxicity in ALS disease models.

Human molecular genetics

Chou CC,Alexeeva OM,Yamada S,Pribadi A,Zhang Y,Mo B,Williams KR,Zarnescu DC,Rossoll W

Tue Sep 15 00:00:00 EDT 2015

PABPN1 suppresses TDP-43 toxicity in ALS disease models.

Human molecular genetics

Chou CC,Alexeeva OM,Yamada S,Pribadi A,Zhang Y,Mo B,Williams KR,Zarnescu DC,Rossoll W

Tue Sep 15 00:00:00 EDT 2015

Overexpression of nuclear FUS induces neuronal cell death.

Neuroscience

Suzuki H,Matsuoka M

Thu Feb 26 00:00:00 EST 2015

Overexpression of nuclear FUS induces neuronal cell death.

Neuroscience

Suzuki H,Matsuoka M

Thu Feb 26 00:00:00 EST 2015

Overexpression of nuclear FUS induces neuronal cell death.

Neuroscience

Suzuki H,Matsuoka M

Thu Feb 26 00:00:00 EST 2015

Overexpression of nuclear FUS induces neuronal cell death.

Neuroscience

Suzuki H,Matsuoka M

Thu Feb 26 00:00:00 EST 2015

Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

In vitro cellular & developmental biology. Animal

Han H,Wei W,Duan W,Guo Y,Li Y,Wang J,Bi Y,Li C

Sun Mar 01 00:00:00 EST 2015

Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

In vitro cellular & developmental biology. Animal

Han H,Wei W,Duan W,Guo Y,Li Y,Wang J,Bi Y,Li C

Sun Mar 01 00:00:00 EST 2015

Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

In vitro cellular & developmental biology. Animal

Han H,Wei W,Duan W,Guo Y,Li Y,Wang J,Bi Y,Li C

Sun Mar 01 00:00:00 EST 2015

Autophagy-linked FYVE protein (Alfy) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

In vitro cellular & developmental biology. Animal

Han H,Wei W,Duan W,Guo Y,Li Y,Wang J,Bi Y,Li C

Sun Mar 01 00:00:00 EST 2015

Loss of TDP-43 Inhibits Amyotrophic Lateral Sclerosis-Linked Mutant SOD1 Aggresome Formation in an HDAC6-Dependent Manner.

Journal of Alzheimer's disease : JAD

Xia Q,Wang H,Zhang Y,Ying Z,Wang G

Thu Jan 14 00:00:00 EST 2016

Loss of TDP-43 Inhibits Amyotrophic Lateral Sclerosis-Linked Mutant SOD1 Aggresome Formation in an HDAC6-Dependent Manner.

Journal of Alzheimer's disease : JAD

Xia Q,Wang H,Zhang Y,Ying Z,Wang G

Thu Jan 14 00:00:00 EST 2016

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.

Acta neuropathologica communications

Goossens J,Vanmechelen E,Trojanowski JQ,Lee VM,Van Broeckhoven C,van der Zee J,Engelborghs S

Wed Apr 01 00:00:00 EDT 2015

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies.

Acta neuropathologica communications

Goossens J,Vanmechelen E,Trojanowski JQ,Lee VM,Van Broeckhoven C,van der Zee J,Engelborghs S

Wed Apr 01 00:00:00 EDT 2015

Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients.

Acta neuropathologica communications

Paré B,Touzel-Deschênes L,Lamontagne R,Lamarre MS,Scott FD,Khuong HT,Dion PA,Bouchard JP,Gould P,Rouleau GA,Dupré N,Berthod F,Gros-Louis F

Sat Jan 31 00:00:00 EST 2015

Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients.

Acta neuropathologica communications

Paré B,Touzel-Deschênes L,Lamontagne R,Lamarre MS,Scott FD,Khuong HT,Dion PA,Bouchard JP,Gould P,Rouleau GA,Dupré N,Berthod F,Gros-Louis F

Sat Jan 31 00:00:00 EST 2015

Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients.

Acta neuropathologica communications

Paré B,Touzel-Deschênes L,Lamontagne R,Lamarre MS,Scott FD,Khuong HT,Dion PA,Bouchard JP,Gould P,Rouleau GA,Dupré N,Berthod F,Gros-Louis F

Sat Jan 31 00:00:00 EST 2015

Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients.

Acta neuropathologica communications

Paré B,Touzel-Deschênes L,Lamontagne R,Lamarre MS,Scott FD,Khuong HT,Dion PA,Bouchard JP,Gould P,Rouleau GA,Dupré N,Berthod F,Gros-Louis F

Sat Jan 31 00:00:00 EST 2015

Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients.

Acta neuropathologica communications

Paré B,Touzel-Deschênes L,Lamontagne R,Lamarre MS,Scott FD,Khuong HT,Dion PA,Bouchard JP,Gould P,Rouleau GA,Dupré N,Berthod F,Gros-Louis F

Sat Jan 31 00:00:00 EST 2015

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

Stem cell reports

Raitano S,Ordovàs L,De Muynck L,Guo W,Espuny-Camacho I,Geraerts M,Khurana S,Vanuytsel K,Tóth BI,Voets T,Vandenberghe R,Cathomen T,Van Den Bosch L,Vanderhaeghen P,Van Damme P,Verfaillie CM

Tue Jan 13 00:00:00 EST 2015

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

Stem cell reports

Raitano S,Ordovàs L,De Muynck L,Guo W,Espuny-Camacho I,Geraerts M,Khurana S,Vanuytsel K,Tóth BI,Voets T,Vandenberghe R,Cathomen T,Van Den Bosch L,Vanderhaeghen P,Van Damme P,Verfaillie CM

Tue Jan 13 00:00:00 EST 2015

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.

Molecular neurodegeneration

Wang G,Yang H,Yan S,Wang CE,Liu X,Zhao B,Ouyang Z,Yin P,Liu Z,Zhao Y,Liu T,Fan N,Guo L,Li S,Li XJ,Lai L

Thu Sep 03 00:00:00 EDT 2015

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.

Molecular neurodegeneration

Wang G,Yang H,Yan S,Wang CE,Liu X,Zhao B,Ouyang Z,Yin P,Liu Z,Zhao Y,Liu T,Fan N,Guo L,Li S,Li XJ,Lai L

Thu Sep 03 00:00:00 EDT 2015

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.

The EMBO journal

Saldi TK,Ash PE,Wilson G,Gonzales P,Garrido-Lecca A,Roberts CM,Dostal V,Gendron TF,Stein LD,Blumenthal T,Petrucelli L,Link CD

Wed Dec 17 00:00:00 EST 2014

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.

The EMBO journal

Saldi TK,Ash PE,Wilson G,Gonzales P,Garrido-Lecca A,Roberts CM,Dostal V,Gendron TF,Stein LD,Blumenthal T,Petrucelli L,Link CD

Wed Dec 17 00:00:00 EST 2014

Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Yang Z,Lin F,Robertson CS,Wang KK

Mon Sep 01 00:00:00 EDT 2014

Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Yang Z,Lin F,Robertson CS,Wang KK

Mon Sep 01 00:00:00 EDT 2014

Astrocytic TDP-43 pathology in Alexander disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Walker AK,Daniels CM,Goldman JE,Trojanowski JQ,Lee VM,Messing A

Wed May 07 00:00:00 EDT 2014

Astrocytic TDP-43 pathology in Alexander disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Walker AK,Daniels CM,Goldman JE,Trojanowski JQ,Lee VM,Messing A

Wed May 07 00:00:00 EDT 2014

Neuroprotection by monocarbonyl dimethoxycurcumin C: ameliorating the toxicity of mutant TDP-43 via HO-1.

Molecular neurobiology

Duan W,Guo Y,Xiao J,Chen X,Li Z,Han H,Li C

Sat Feb 01 00:00:00 EST 2014

Neuroprotection by monocarbonyl dimethoxycurcumin C: ameliorating the toxicity of mutant TDP-43 via HO-1.

Molecular neurobiology

Duan W,Guo Y,Xiao J,Chen X,Li Z,Han H,Li C

Sat Feb 01 00:00:00 EST 2014

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.

Journal of cell science

Huang CC,Bose JK,Majumder P,Lee KH,Huang JT,Huang JK,Shen CK

Tue Jul 15 00:00:00 EDT 2014

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.

Journal of cell science

Huang CC,Bose JK,Majumder P,Lee KH,Huang JT,Huang JK,Shen CK

Tue Jul 15 00:00:00 EDT 2014

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.

Journal of cell science

Huang CC,Bose JK,Majumder P,Lee KH,Huang JT,Huang JK,Shen CK

Tue Jul 15 00:00:00 EDT 2014

Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice.

Journal of Alzheimer's disease : JAD

Rodriguez-Ortiz CJ,Baglietto-Vargas D,Martinez-Coria H,LaFerla FM,Kitazawa M

Thu Jul 23 00:00:00 EDT 2015

Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice.

Journal of Alzheimer's disease : JAD

Rodriguez-Ortiz CJ,Baglietto-Vargas D,Martinez-Coria H,LaFerla FM,Kitazawa M

Thu Jul 23 00:00:00 EDT 2015

A new cellular model of pathological TDP-43: The neurotoxicity of stably expressed CTF25 of TDP-43 depends on the proteasome.

Neuroscience

Liu Y,Duan W,Guo Y,Li Z,Han H,Zhang S,Yuan P,Li C

Fri Dec 05 00:00:00 EST 2014

A new cellular model of pathological TDP-43: The neurotoxicity of stably expressed CTF25 of TDP-43 depends on the proteasome.

Neuroscience

Liu Y,Duan W,Guo Y,Li Z,Han H,Zhang S,Yuan P,Li C

Fri Dec 05 00:00:00 EST 2014

A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.

PloS one

Ricketts T,McGoldrick P,Fratta P,de Oliveira HM,Kent R,Phatak V,Brandner S,Blanco G,Greensmith L,Acevedo-Arozena A,Fisher EM

Wed Oct 29 00:00:00 EDT 2014

A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.

PloS one

Ricketts T,McGoldrick P,Fratta P,de Oliveira HM,Kent R,Phatak V,Brandner S,Blanco G,Greensmith L,Acevedo-Arozena A,Fisher EM

Wed Oct 29 00:00:00 EDT 2014

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.

Molecular neurodegeneration

Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P

Tue Jun 17 00:00:00 EDT 2014

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.

Molecular neurodegeneration

Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P

Tue Jun 17 00:00:00 EDT 2014

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.

Molecular neurodegeneration

Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P

Tue Jun 17 00:00:00 EDT 2014

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.

Molecular neurodegeneration

Herdewyn S,Cirillo C,Van Den Bosch L,Robberecht W,Vanden Berghe P,Van Damme P

Tue Jun 17 00:00:00 EDT 2014

Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic memory deficits.

Acta neuropathologica communications

Ohta Y,Tremblay C,Schneider JA,Bennett DA,Calon F,Julien JP

Tue Apr 01 00:00:00 EDT 2014

Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic memory deficits.

Acta neuropathologica communications

Ohta Y,Tremblay C,Schneider JA,Bennett DA,Calon F,Julien JP

Tue Apr 01 00:00:00 EDT 2014

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Nature communications

Stoica R,De Vos KJ,Paillusson S,Mueller S,Sancho RM,Lau KF,Vizcay-Barrena G,Lin WL,Xu YF,Lewis J,Dickson DW,Petrucelli L,Mitchell JC,Shaw CE,Miller CC

Tue Jun 03 00:00:00 EDT 2014

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Nature communications

Stoica R,De Vos KJ,Paillusson S,Mueller S,Sancho RM,Lau KF,Vizcay-Barrena G,Lin WL,Xu YF,Lewis J,Dickson DW,Petrucelli L,Mitchell JC,Shaw CE,Miller CC

Tue Jun 03 00:00:00 EDT 2014

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Nature communications

Stoica R,De Vos KJ,Paillusson S,Mueller S,Sancho RM,Lau KF,Vizcay-Barrena G,Lin WL,Xu YF,Lewis J,Dickson DW,Petrucelli L,Mitchell JC,Shaw CE,Miller CC

Tue Jun 03 00:00:00 EDT 2014

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Nature communications

Stoica R,De Vos KJ,Paillusson S,Mueller S,Sancho RM,Lau KF,Vizcay-Barrena G,Lin WL,Xu YF,Lewis J,Dickson DW,Petrucelli L,Mitchell JC,Shaw CE,Miller CC

Tue Jun 03 00:00:00 EDT 2014

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

Proceedings of the National Academy of Sciences of the United States of America

Arnold ES,Ling SC,Huelga SC,Lagier-Tourenne C,Polymenidou M,Ditsworth D,Kordasiewicz HB,McAlonis-Downes M,Platoshyn O,Parone PA,Da Cruz S,Clutario KM,Swing D,Tessarollo L,Marsala M,Shaw CE,Yeo GW,Cleveland DW

Tue Feb 19 00:00:00 EST 2013

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

Proceedings of the National Academy of Sciences of the United States of America

Tue Feb 19 00:00:00 EST 2013

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

Proceedings of the National Academy of Sciences of the United States of America

Tue Feb 19 00:00:00 EST 2013

Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration.

The Journal of cell biology

Zhao H,Zhao YG,Wang X,Xu L,Miao L,Feng D,Chen Q,Kovács AL,Fan D,Zhang H

Mon Mar 18 00:00:00 EDT 2013

Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration.

The Journal of cell biology

Zhao H,Zhao YG,Wang X,Xu L,Miao L,Feng D,Chen Q,Kovács AL,Fan D,Zhang H

Mon Mar 18 00:00:00 EDT 2013

Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration.

The Journal of cell biology

Zhao H,Zhao YG,Wang X,Xu L,Miao L,Feng D,Chen Q,Kovács AL,Fan D,Zhang H

Mon Mar 18 00:00:00 EDT 2013

Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration.

The Journal of cell biology

Zhao H,Zhao YG,Wang X,Xu L,Miao L,Feng D,Chen Q,Kovács AL,Fan D,Zhang H

Mon Mar 18 00:00:00 EDT 2013

Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.

The American journal of pathology

Rodriguez-Ortiz CJ,Hoshino H,Cheng D,Liu-Yescevitz L,Blurton-Jones M,Wolozin B,LaFerla FM,Kitazawa M

Thu Aug 01 00:00:00 EDT 2013

Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.

The American journal of pathology

Rodriguez-Ortiz CJ,Hoshino H,Cheng D,Liu-Yescevitz L,Blurton-Jones M,Wolozin B,LaFerla FM,Kitazawa M

Thu Aug 01 00:00:00 EDT 2013

Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.

The American journal of pathology

Rodriguez-Ortiz CJ,Hoshino H,Cheng D,Liu-Yescevitz L,Blurton-Jones M,Wolozin B,LaFerla FM,Kitazawa M

Thu Aug 01 00:00:00 EDT 2013

Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.

The American journal of pathology

Rodriguez-Ortiz CJ,Hoshino H,Cheng D,Liu-Yescevitz L,Blurton-Jones M,Wolozin B,LaFerla FM,Kitazawa M

Thu Aug 01 00:00:00 EDT 2013

Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.

The American journal of pathology

Rodriguez-Ortiz CJ,Hoshino H,Cheng D,Liu-Yescevitz L,Blurton-Jones M,Wolozin B,LaFerla FM,Kitazawa M

Thu Aug 01 00:00:00 EDT 2013

Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.

Human molecular genetics

Hewamadduma CA,Grierson AJ,Ma TP,Pan L,Moens CB,Ingham PW,Ramesh T,Shaw PJ

Sat Jun 15 00:00:00 EDT 2013

Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish.

Human molecular genetics

Hewamadduma CA,Grierson AJ,Ma TP,Pan L,Moens CB,Ingham PW,Ramesh T,Shaw PJ

Sat Jun 15 00:00:00 EDT 2013

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.

Human molecular genetics

Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L

Thu Aug 01 00:00:00 EDT 2013

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.

Human molecular genetics

Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L

Thu Aug 01 00:00:00 EDT 2013

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.

Human molecular genetics

Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L

Thu Aug 01 00:00:00 EDT 2013

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.

Human molecular genetics

Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L

Thu Aug 01 00:00:00 EDT 2013

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.

Human molecular genetics

Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L

Thu Aug 01 00:00:00 EDT 2013

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.

Human molecular genetics

Zhang YJ,Caulfield T,Xu YF,Gendron TF,Hubbard J,Stetler C,Sasaguri H,Whitelaw EC,Cai S,Lee WC,Petrucelli L

Thu Aug 01 00:00:00 EDT 2013

The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death.

Molecular and cellular biochemistry

Suzuki H,Matsuoka M

Tue Jan 01 00:00:00 EST 2013

The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death.

Molecular and cellular biochemistry

Suzuki H,Matsuoka M

Tue Jan 01 00:00:00 EST 2013

Heat-shock protein dysregulation is associated with functional and pathological TDP-43 aggregation.

Nature communications

Chang HY,Hou SC,Way TD,Wong CH,Wang IF

Thu Jun 19 00:00:00 EDT 2014

Heat-shock protein dysregulation is associated with functional and pathological TDP-43 aggregation.

Nature communications

Chang HY,Hou SC,Way TD,Wong CH,Wang IF

Thu Jun 19 00:00:00 EDT 2014

Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology.

Acta neuropathologica

Teyssou E,Takeda T,Lebon V,Boillée S,Doukouré B,Bataillon G,Sazdovitch V,Cazeneuve C,Meininger V,LeGuern E,Salachas F,Seilhean D,Millecamps S

Mon Apr 01 00:00:00 EDT 2013

Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.

Biochimica et biophysica acta

Cassel JA,Reitz AB

Sat Jun 01 00:00:00 EDT 2013

Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolines.

Biochimica et biophysica acta

Cassel JA,Reitz AB

Sat Jun 01 00:00:00 EDT 2013

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.

Brain : a journal of neurology

Uchida A,Sasaguri H,Kimura N,Tajiri M,Ohkubo T,Ono F,Sakaue F,Kanai K,Hirai T,Sano T,Shibuya K,Kobayashi M,Yamamoto M,Yokota S,Kubodera T,Tomori M,Sakaki K,Enomoto M,Hirai Y,Kumagai J,Yasutomi Y,Mochizuki H,Kuwabara S,Uchihara T,Mizusawa H,Yokota T

Thu Mar 01 00:00:00 EST 2012

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.

Brain : a journal of neurology

Thu Mar 01 00:00:00 EST 2012

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.

Brain : a journal of neurology

Thu Mar 01 00:00:00 EST 2012

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Vanderweyde T,Yu H,Varnum M,Liu-Yesucevitz L,Citro A,Ikezu T,Duff K,Wolozin B

Wed Jun 13 00:00:00 EDT 2012

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Vanderweyde T,Yu H,Varnum M,Liu-Yesucevitz L,Citro A,Ikezu T,Duff K,Wolozin B

Wed Jun 13 00:00:00 EDT 2012

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Vanderweyde T,Yu H,Varnum M,Liu-Yesucevitz L,Citro A,Ikezu T,Duff K,Wolozin B

Wed Jun 13 00:00:00 EDT 2012

TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression.

Journal of neuroscience research

Suzuki H,Matsuoka M

Thu Mar 01 00:00:00 EST 2012

TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression.

Journal of neuroscience research

Suzuki H,Matsuoka M

Thu Mar 01 00:00:00 EST 2012

Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.

Biochimie

Cassel JA,McDonnell ME,Velvadapu V,Andrianov V,Reitz AB

Sat Sep 01 00:00:00 EDT 2012

Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.

Biochimie

Cassel JA,McDonnell ME,Velvadapu V,Andrianov V,Reitz AB

Sat Sep 01 00:00:00 EDT 2012

Rodent models of TDP-43: recent advances.

Brain research

Tsao W,Jeong YH,Lin S,Ling J,Price DL,Chiang PM,Wong PC

Tue Jun 26 00:00:00 EDT 2012

Rodent models of TDP-43: recent advances.

Brain research

Tsao W,Jeong YH,Lin S,Ling J,Price DL,Chiang PM,Wong PC

Tue Jun 26 00:00:00 EDT 2012

Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells.

Neuroscience letters

Lee K,Suzuki H,Aiso S,Matsuoka M

Wed Jan 11 00:00:00 EST 2012

Overexpression of TDP-43 causes partially p53-dependent G2/M arrest and p53-independent cell death in HeLa cells.

Neuroscience letters

Lee K,Suzuki H,Aiso S,Matsuoka M

Wed Jan 11 00:00:00 EST 2012

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line.

Neuroscience letters

Hong K,Li Y,Duan W,Guo Y,Jiang H,Li W,Li C

Wed Nov 21 00:00:00 EST 2012

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line.

Neuroscience letters

Hong K,Li Y,Duan W,Guo Y,Jiang H,Li W,Li C

Wed Nov 21 00:00:00 EST 2012

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line.

Neuroscience letters

Hong K,Li Y,Duan W,Guo Y,Jiang H,Li W,Li C

Wed Nov 21 00:00:00 EST 2012

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line.

Neuroscience letters

Hong K,Li Y,Duan W,Guo Y,Jiang H,Li W,Li C

Wed Nov 21 00:00:00 EST 2012

In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments.

Neuropathology and applied neurobiology

D'Agostino C,Nogalska A,Engel WK,Askanas V

Fri Apr 01 00:00:00 EDT 2011

In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments.

Neuropathology and applied neurobiology

D'Agostino C,Nogalska A,Engel WK,Askanas V

Fri Apr 01 00:00:00 EDT 2011

Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity.

Journal of neurochemistry

Suzuki H,Matsuoka M

Thu Dec 01 00:00:00 EST 2011

Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity.

Journal of neurochemistry

Suzuki H,Matsuoka M

Thu Dec 01 00:00:00 EST 2011

Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease.

Journal of neuropathology and experimental neurology

Tremblay C,St-Amour I,Schneider J,Bennett DA,Calon F

Thu Sep 01 00:00:00 EDT 2011

Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease.

Journal of neuropathology and experimental neurology

Tremblay C,St-Amour I,Schneider J,Bennett DA,Calon F

Thu Sep 01 00:00:00 EDT 2011

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Molecular neurodegeneration

Xu YF,Zhang YJ,Lin WL,Cao X,Stetler C,Dickson DW,Lewis J,Petrucelli L

Wed Oct 26 00:00:00 EDT 2011

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Molecular neurodegeneration

Xu YF,Zhang YJ,Lin WL,Cao X,Stetler C,Dickson DW,Lewis J,Petrucelli L

Wed Oct 26 00:00:00 EDT 2011

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Molecular neurodegeneration

Xu YF,Zhang YJ,Lin WL,Cao X,Stetler C,Dickson DW,Lewis J,Petrucelli L

Wed Oct 26 00:00:00 EDT 2011

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Molecular neurodegeneration

Xu YF,Zhang YJ,Lin WL,Cao X,Stetler C,Dickson DW,Lewis J,Petrucelli L

Wed Oct 26 00:00:00 EDT 2011

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.

The Journal of biological chemistry

Suzuki H,Lee K,Matsuoka M

Fri Apr 15 00:00:00 EDT 2011

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.

The Journal of biological chemistry

Suzuki H,Lee K,Matsuoka M

Fri Apr 15 00:00:00 EDT 2011

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Neuron

Hu F,Padukkavidana T,Vægter CB,Brady OA,Zheng Y,Mackenzie IR,Feldman HH,Nykjaer A,Strittmatter SM

Thu Nov 18 00:00:00 EST 2010

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Neuron

Hu F,Padukkavidana T,Vægter CB,Brady OA,Zheng Y,Mackenzie IR,Feldman HH,Nykjaer A,Strittmatter SM

Thu Nov 18 00:00:00 EST 2010

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Xu YF,Gendron TF,Zhang YJ,Lin WL,D'Alton S,Sheng H,Casey MC,Tong J,Knight J,Yu X,Rademakers R,Boylan K,Hutton M,McGowan E,Dickson DW,Lewis J,Petrucelli L

Wed Aug 11 00:00:00 EDT 2010

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Xu YF,Gendron TF,Zhang YJ,Lin WL,D'Alton S,Sheng H,Casey MC,Tong J,Knight J,Yu X,Rademakers R,Boylan K,Hutton M,McGowan E,Dickson DW,Lewis J,Petrucelli L

Wed Aug 11 00:00:00 EDT 2010

Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell.

Neuroscience

Duan W,Li X,Shi J,Guo Y,Li Z,Li C

Wed Sep 15 00:00:00 EDT 2010

Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell.

Neuroscience

Duan W,Li X,Shi J,Guo Y,Li Z,Li C

Wed Sep 15 00:00:00 EDT 2010

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.

Genesis (New York, N.Y. : 2000)

Wu LS,Cheng WC,Hou SC,Yan YT,Jiang ST,Shen CK

Fri Jan 01 00:00:00 EST 2010

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.

Genesis (New York, N.Y. : 2000)

Wu LS,Cheng WC,Hou SC,Yan YT,Jiang ST,Shen CK

Fri Jan 01 00:00:00 EST 2010

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.

Genesis (New York, N.Y. : 2000)

Wu LS,Cheng WC,Hou SC,Yan YT,Jiang ST,Shen CK

Fri Jan 01 00:00:00 EST 2010

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.

Genesis (New York, N.Y. : 2000)

Wu LS,Cheng WC,Hou SC,Yan YT,Jiang ST,Shen CK

Fri Jan 01 00:00:00 EST 2010

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

The Journal of biological chemistry

Kim SH,Shanware NP,Bowler MJ,Tibbetts RS

Fri Oct 29 00:00:00 EDT 2010

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

The Journal of biological chemistry

Kim SH,Shanware NP,Bowler MJ,Tibbetts RS

Fri Oct 29 00:00:00 EDT 2010

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

The Journal of biological chemistry

Kim SH,Shanware NP,Bowler MJ,Tibbetts RS

Fri Oct 29 00:00:00 EDT 2010

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

The Journal of biological chemistry

Kim SH,Shanware NP,Bowler MJ,Tibbetts RS

Fri Oct 29 00:00:00 EDT 2010

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Human molecular genetics

Ferguson CJ,Lenk GM,Meisler MH

Tue Dec 15 00:00:00 EST 2009

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Human molecular genetics

Ferguson CJ,Lenk GM,Meisler MH

Tue Dec 15 00:00:00 EST 2009

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Human molecular genetics

Ferguson CJ,Lenk GM,Meisler MH

Tue Dec 15 00:00:00 EST 2009

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Human molecular genetics

Ferguson CJ,Lenk GM,Meisler MH

Tue Dec 15 00:00:00 EST 2009

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability.

The Journal of biological chemistry

Caccamo A,Majumder S,Deng JJ,Bai Y,Thornton FB,Oddo S

Fri Oct 02 00:00:00 EDT 2009

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability.

The Journal of biological chemistry

Caccamo A,Majumder S,Deng JJ,Bai Y,Thornton FB,Oddo S

Fri Oct 02 00:00:00 EDT 2009

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability.

The Journal of biological chemistry

Caccamo A,Majumder S,Deng JJ,Bai Y,Thornton FB,Oddo S

Fri Oct 02 00:00:00 EDT 2009

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability.

The Journal of biological chemistry

Caccamo A,Majumder S,Deng JJ,Bai Y,Thornton FB,Oddo S

Fri Oct 02 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: OTTHUMP00000002171; OTTHUMP00000002173; RP4-635E18.2; TAR DNA-binding protein 43; TAR DNA-binding protein-43; TDP-43

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Gene Aliases: 1190002A23Rik; ALS10; C85084; TARDBP; TDP-43; TDP43

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UniProt ID: (Human) Q13148, (Mouse) Q921F2

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Entrez Gene ID: (Human) 23435, (Mouse) 230908, (Rat) 298648

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Function(s)

nucleotide binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA binding mRNA 3'-UTR binding protein binding identical protein binding poly(A) RNA binding nucleic acid binding DNA binding

Process(es)

negative regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter mRNA processing RNA splicing negative regulation of gene expression nuclear fragmentation involved in apoptotic nuclear change negative regulation by host of viral transcription positive regulation of transcription from RNA polymerase II promoter regulation of cell cycle 3'-UTR-mediated mRNA stabilization nuclear inner membrane organization positive regulation of insulin secretion response to endoplasmic reticulum stress

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TDP-43 (C-terminal) Polyclonal Antibody

TDP-43 (C-terminal) Antibody (12892-1-AP) in ICC/IF

Product Details

12892-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

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Published species

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