Proteintech

TDRKH Polyclonal Antibody

TDRKH Antibody in Immunocytochemistry (ICC/IF)

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TDRKH Antibody (13528-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 13528-1-AP (TDRKH specific antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

TDRKH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TDRKH Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13528-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TDRKH specific Fusion Protein Ag4422 (1-376 aa encoded by BC032690)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSTERTSWT SLSTIQKIAL GFGIPASATV AYILYRRYRE SREERLTFVG EDDIEIEMRV PQEAVKLIIG RQGANIKQLR KQTGARIDVD TEDVGDERVL LISGFPVQVC KAKAAIHQIL TENTPVSEQL SVPQRSVGRI IGRGGETIRS ICKASGAKIT CDKESEGTLL LSRLIKISGT QKEVAAAKHL ILEKVSEDEE LRKRIAHSAE TRVPRKQPIS VRREDMTEPG GAGEPALWKN TSSSMEPTAP LVTPPPKAGG DMAVVVSKEG SWEKPSDDSF QKSEAQAIPE MPMFEIPSPD FSFHADEYLE VYVSASEHPN HFWIQIVGSR SLQLDKLVNE MTQHYENSVP EDLTVHVGDI VAAPLPTNGS WYRAR (1-376 aa encoded by BC032690)

Target Information

TDRKH is a protein of unknown function containing one tudor domain, and two KH domains. It has been found to interact with PIWIL1 and PIWIL4 by binding to methylated arginines residues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Three RNA-binding protein signature as a novel biomarker to predict endometrial cancer prognosis.

American journal of translational research

Wang B,Ma X

Tue Feb 14 00:00:00 EST 2023

Three RNA-binding protein signature as a novel biomarker to predict endometrial cancer prognosis.

American journal of translational research

Wang B,Ma X

Tue Feb 14 00:00:00 EST 2023

MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.

Development (Cambridge, England)

Wang X,Wen Y,Zhang J,Swanson G,Guo S,Cao C,Krawetz SA,Zhang Z,Yuan S

Thu Apr 01 00:00:00 EDT 2021

MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.

Development (Cambridge, England)

Wang X,Wen Y,Zhang J,Swanson G,Guo S,Cao C,Krawetz SA,Zhang Z,Yuan S

Thu Apr 01 00:00:00 EDT 2021

MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.

Development (Cambridge, England)

Wang X,Wen Y,Zhang J,Swanson G,Guo S,Cao C,Krawetz SA,Zhang Z,Yuan S

Thu Apr 01 00:00:00 EDT 2021

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1.

Science advances

Antico O,Ordureau A,Stevens M,Singh F,Nirujogi RS,Gierlinski M,Barini E,Rickwood ML,Prescott A,Toth R,Ganley IG,Harper JW,Muqit MMK

Fri Nov 12 00:00:00 EST 2021

Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors.

Nature cell biology

Sun YH,Zhu J,Xie LH,Li Z,Meduri R,Zhu X,Song C,Chen C,Ricci EP,Weng Z,Li XZ

Sat Feb 01 00:00:00 EST 2020

PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.

Cells

Tan M,Tol HTAV,Rosenkranz D,Roovers EF,Damen MJ,Stout TAE,Wu W,Roelen BAJ

Fri May 29 00:00:00 EDT 2020

PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.

Cells

Tan M,Tol HTAV,Rosenkranz D,Roovers EF,Damen MJ,Stout TAE,Wu W,Roelen BAJ

Fri May 29 00:00:00 EDT 2020

PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.

Cells

Tan M,Tol HTAV,Rosenkranz D,Roovers EF,Damen MJ,Stout TAE,Wu W,Roelen BAJ

Fri May 29 00:00:00 EDT 2020

PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.

Cells

Tan M,Tol HTAV,Rosenkranz D,Roovers EF,Damen MJ,Stout TAE,Wu W,Roelen BAJ

Fri May 29 00:00:00 EDT 2020

MIWI prevents aneuploidy during meiosis by cleaving excess satellite RNA.

The EMBO journal

Hsieh CL,Xia J,Lin H

Mon Aug 17 00:00:00 EDT 2020

Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis.

Nucleic acids research

Ding D,Liu J,Dong K,Melnick AF,Latham KE,Chen C

Mon Mar 18 00:00:00 EDT 2019

Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis.

Nucleic acids research

Ding D,Liu J,Dong K,Melnick AF,Latham KE,Chen C

Mon Mar 18 00:00:00 EDT 2019

High levels of PIWI-interacting RNAs are present in the small RNA landscape of prostate epithelium from vitamin D clinical trial specimens.

The Prostate

Baumann B,Lugli G,Gao S,Zenner M,Nonn L

Sat Jun 01 00:00:00 EDT 2019

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Proteomics

Wang X,Wen Y,Dong J,Cao C,Yuan S

Sun Jul 01 00:00:00 EDT 2018

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Proteomics

Wang X,Wen Y,Dong J,Cao C,Yuan S

Sun Jul 01 00:00:00 EDT 2018

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Proteomics

Wang X,Wen Y,Dong J,Cao C,Yuan S

Sun Jul 01 00:00:00 EDT 2018

PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice.

Nature communications

Ding D,Liu J,Dong K,Midic U,Hess RA,Xie H,Demireva EY,Chen C

Tue Oct 10 00:00:00 EDT 2017

PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice.

Nature communications

Ding D,Liu J,Dong K,Midic U,Hess RA,Xie H,Demireva EY,Chen C

Tue Oct 10 00:00:00 EDT 2017

PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice.

Nature communications

Ding D,Liu J,Dong K,Midic U,Hess RA,Xie H,Demireva EY,Chen C

Tue Oct 10 00:00:00 EDT 2017

PNLDC1 is essential for piRNA 3' end trimming and transposon silencing during spermatogenesis in mice.

Nature communications

Ding D,Liu J,Dong K,Midic U,Hess RA,Xie H,Demireva EY,Chen C

Tue Oct 10 00:00:00 EDT 2017

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline.

The EMBO journal

Saxe JP,Chen M,Zhao H,Lin H

Wed Jul 03 00:00:00 EDT 2013

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline.

The EMBO journal

Saxe JP,Chen M,Zhao H,Lin H

Wed Jul 03 00:00:00 EDT 2013

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline.

The EMBO journal

Saxe JP,Chen M,Zhao H,Lin H

Wed Jul 03 00:00:00 EDT 2013

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline.

The EMBO journal

Saxe JP,Chen M,Zhao H,Lin H

Wed Jul 03 00:00:00 EDT 2013

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

Proceedings of the National Academy of Sciences of the United States of America

Chen C,Jin J,James DA,Adams-Cioaba MA,Park JG,Guo Y,Tenaglia E,Xu C,Gish G,Min J,Pawson T

Tue Dec 01 00:00:00 EST 2009

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

Proceedings of the National Academy of Sciences of the United States of America

Chen C,Jin J,James DA,Adams-Cioaba MA,Park JG,Guo Y,Tenaglia E,Xu C,Gish G,Min J,Pawson T

Tue Dec 01 00:00:00 EST 2009

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

Proceedings of the National Academy of Sciences of the United States of America

Chen C,Jin J,James DA,Adams-Cioaba MA,Park JG,Guo Y,Tenaglia E,Xu C,Gish G,Min J,Pawson T

Tue Dec 01 00:00:00 EST 2009

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.

Proceedings of the National Academy of Sciences of the United States of America

Chen C,Jin J,James DA,Adams-Cioaba MA,Park JG,Guo Y,Tenaglia E,Xu C,Gish G,Min J,Pawson T

Tue Dec 01 00:00:00 EST 2009

Bioinformatics

Protein Aliases: putative RNA binding protein; RP11-98D18.8; TDRD7; tudor and KH domain containing protein; Tudor and KH domain-containing protein; tudor domain containing 2; Tudor domain-containing protein 2

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Gene Aliases: 2700091C21Rik; RGD1311196; TDRD2; TDRKH

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UniProt ID: (Human) Q9Y2W6, (Mouse) Q80VL1

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Entrez Gene ID: (Human) 11022, (Mouse) 72634, (Rat) 310652

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Function(s)

RNA binding nucleic acid binding protein binding scaffold/adaptor protein

Process(es)

male meiosis spermatogenesis fertilization cell differentiation gene silencing by RNA piRNA metabolic process DNA methylation involved in gamete generation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TDRKH Polyclonal Antibody

TDRKH Antibody (13528-1-AP) in ICC/IF

Product Details

13528-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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