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Product Details
11022-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
PCRP-TDRKH-1H2
Immunogen
Recombinant full-length human TDRKH protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is stable for 24 months.
Positive Control: HeLa or MCF7 cells.Human testis or brain. Cellular Localization: Cytoplasm. Localized to cytosol and centrosome.
Specificity Comments: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Predicted to react with Mouse and Rat
Target Information
TDRKH is a protein of unknown function containing one tudor domain, and two KH domains. It has been found to interact with PIWIL1 and PIWIL4 by binding to methylated arginines residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: putative RNA binding protein; RP11-98D18.8; TDRD7; tudor and KH domain containing protein; Tudor and KH domain-containing protein; tudor domain containing 2; Tudor domain-containing protein 2
Gene Aliases: TDRD2; TDRKH
UniProt ID: (Human) Q9Y2W6
Entrez Gene ID: (Human) 11022
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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