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Product Details
MA5-38639
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3H2C12
Immunogen
Purified recombinant fragment of human TERT (aa: 1029-1132) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898551
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HEST2; hTERT; Telomerase catalytic subunit; Telomerase reverse transcriptase; Telomerase-associated protein 2; TP2
Gene Aliases: CMM9; DKCA2; DKCB4; EST2; hEST2; hTRT; PFBMFT1; TCS1; TERT; TP2; TRT
UniProt ID: (Human) O14746
Entrez Gene ID: (Human) 7015
tRNA binding
transcription coactivator binding
DNA binding
telomerase activity
telomerase RNA reverse transcriptase activity
RNA binding
RNA-directed DNA polymerase activity
RNA-directed RNA polymerase activity
protein binding
nucleotidyltransferase activity
telomeric DNA binding
protein homodimerization activity
metal ion binding
telomerase RNA binding
DNA metabolism protein
telomere maintenance
transcription, RNA-templated
RNA-dependent DNA biosynthetic process
telomere maintenance via telomerase
mitochondrion organization
negative regulation of gene expression
DNA strand elongation
positive regulation of Wnt signaling pathway
production of siRNA involved in RNA interference
regulation of protein stability
positive regulation of protein binding
RNA biosynthetic process
positive regulation of hair cycle
positive regulation of nitric-oxide synthase activity
establishment of protein localization to telomere
cellular response to hypoxia
DNA biosynthetic process
replicative senescence
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of production of siRNA involved in RNA interference
positive regulation of protein localization to nucleolus
beta-catenin-TCF complex assembly
positive regulation of stem cell proliferation
negative regulation of cellular senescence
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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