Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: DTSRIPARF FTTPSQAKGI DFQLFLKSQV RRIEMEDPCL MLASRFKQVQ TLAVTADAFF CLYSYVSKTP VQKFTPSHMF WNCNHPTDVP SIRILSREPE PQSPRDRLRK AISKMCLYTC PRDRPPPPHN TPKRNSLDQV VLEVMDKVKE EKQFLQQDSD LGQFSQEDPV PPAEGKKLPT SPYPCVFCCE EETQQRMSTV LAPSQTLDSN PKVPCCTHSL PIEDPQWSTD PAQIRRELCS LPATNTETHP AKDETFWKRK SRARKSLFQK NLMGRKVKSL DLSITQQKWK QSVDRPELRR SLSQQPQDTF DLEEVQSNSE EEQSQSRWPS RPRHPHHHQT FAGKDS (177-521 aa encoded by BC132732)
TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development. TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species. TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage. TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Protein TESPA1; thymocyte expressed; Thymocyte-expressed positive selection-associated protein 1
Gene Aliases: HSPC257; KIAA0748; TESPA1
UniProt ID: (Human) A2RU30
Entrez Gene ID: (Human) 9840
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