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Product Details
BS-1921R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TFF2, amino acids 51-129.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SP; Spasmolysin; Spasmolytic polypeptide; spasmolytic protein 1; Trefoil factor 2; trefoil factor 2 (spasmolytic protein 1)
Gene Aliases: mSP; SML1; SP; TFF2
UniProt ID: (Human) Q03403, (Rat) Q09030
Entrez Gene ID: (Human) 7032, (Rat) 116592, (Mouse) 21785
digestion
positive regulation of cell proliferation
calcium-mediated signaling
regulation of cell migration
negative regulation of macrophage activation
negative regulation of inflammatory response
negative regulation of gastric acid secretion
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
Performance Guarantee
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