Proteintech

TGF Beta 3 Polyclonal Antibody

TGF Beta 3 Antibody in Western Blot (WB)

FIGURE: 1 / 1

TGF Beta 3 Antibody (18942-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 18942-1-AP (TGF-beta 3 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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Product Details

18942-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:800

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TGFB3 Fusion Protein Ag13507

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Polyphenol-driven facile assembly of a nanosized acid fibroblast growth factor-containing coacervate accelerates the healing of diabetic wounds.

Acta biomaterialia

Tong MQ,Lu CT,Huang LT,Yang JJ,Yang ST,Chen HB,Xue PP,Luo LZ,Yao Q,Xu HL,Zhao YZ

Wed Feb 01 00:00:00 EST 2023

Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.

The EMBO journal

Wang L,Wu L,Zhu Z,Zhang Q,Li W,Gonzalez GM,Wang Y,Rana TM

Mon Jan 16 00:00:00 EST 2023

Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy.

BMC genomics

Zhang R,Xu X,Chen X,Hao C,Ji Z,Zuo P,Yang M,Ma G,Li Y

Sun Aug 14 00:00:00 EDT 2022

A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.

Frontiers in immunology

Khan M,Lin J,Wang B,Chen C,Huang Z,Tian Y,Yuan Y,Bu J

Mon Nov 21 00:00:00 EST 2022

Identification of polyunsaturated fatty acids related key modules and genes in metabolic dysfunction-associated fatty liver disease using WGCNA analysis.

Frontiers in genetics

Xiao C,Chen S,Yang C,Liu J,Yu M

Sat Nov 26 00:00:00 EST 2022

Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer.

Journal of medicinal chemistry

Gou Y,Chen M,Li S,Deng J,Li J,Fang G,Yang F,Huang G

Thu May 13 00:00:00 EDT 2021

Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration.

NPJ Regenerative medicine

Bello AB,Kim Y,Park S,Muttigi MS,Kim J,Park H,Lee S

Fri Sep 03 00:00:00 EDT 2021

HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis.

Journal of experimental & clinical cancer research : CR

Song C,Zhou C

Tue Feb 09 00:00:00 EST 2021

The regulation of CIRBP by transforming growth factor beta during heat shock-induced testicular injury.

Andrology

Rao M,Ke D,Cheng G,Hu S,Wu Y,Wang Y,Zhou F,Liu H,Zhu C,Xia W

Fri Mar 01 00:00:00 EST 2019

Modulation of TGF‑β activity by latent TGF‑β‑binding protein 1 in human osteoarthritis fibroblast‑like synoviocytes.

Molecular medicine reports

Wang X,Dong C,Li N,Ma Q,Yun Z,Cai C,An M,Ma B

Mon Jan 01 00:00:00 EST 2018

Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-β3 Signaling Pathway.

BioMed research international

Zhou XL,Chen G,Li MX,Wang HX,Hong JW,Shen JY,Wang Q,Ge X,Ding Z,Xu LC

Wed Jan 23 00:00:00 EST 2019

Overexpression of YOD1 Promotes the Migration of Human Oral Keratinocytes by Enhancing TGF-β3 Signaling.

Biomedical and environmental sciences : BES

Ju Q,Li MX,Chen G,Wang HX,Shi QM,Ge X,Ding Z,Wang Q,Xu LC

Sun Jul 01 00:00:00 EDT 2018

Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.

Scientific reports

Wang L,Hu L,Zhou X,Xiong Z,Zhang C,Shehada HMA,Hu B,Song J,Chen L

Tue Oct 17 00:00:00 EDT 2017

Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.

Scientific reports

Wang L,Hu L,Zhou X,Xiong Z,Zhang C,Shehada HMA,Hu B,Song J,Chen L

Tue Oct 17 00:00:00 EDT 2017

Tranilast Inhibits Genes Functionally Involved in Cell Proliferation, Fibrosis, and Epigenetic Regulation and Epigenetically Induces miR-29c Expression in Leiomyoma Cells.

Reproductive sciences (Thousand Oaks, Calif.)

Chuang TD,Khorram O

Fri Sep 01 00:00:00 EDT 2017

CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.

Bone

Yoshioka Y,Ono M,Maeda A,Kilts TM,Hara ES,Khattab H,Ueda J,Aoyama E,Oohashi T,Takigawa M,Young MF,Kuboki T

Mon Feb 01 00:00:00 EST 2016

Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint.

Scientific reports

Li Y,El Mozen LA,Cai H,Fang W,Meng Q,Li J,Deng M,Long X

Fri Mar 06 00:00:00 EST 2015

SIX1 promotes tumor lymphangiogenesis by coordinating TGFβ signals that increase expression of VEGF-C.

Cancer research

Liu D,Li L,Zhang XX,Wan DY,Xi BX,Hu Z,Ding WC,Zhu D,Wang XL,Wang W,Feng ZH,Wang H,Ma D,Gao QL

Wed Oct 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3

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Gene Aliases: ARVD; ARVD1; LDS5; RNHF; TGF-beta3; Tgfb-3; TGFB3

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UniProt ID: (Human) P10600

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Entrez Gene ID: (Human) 7043, (Mouse) 21809

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Function(s)

type II transforming growth factor beta receptor binding cytokine activity protein binding growth factor activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding identical protein binding protein heterodimerization activity transforming growth factor beta binding transforming growth factor beta receptor binding growth factor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TGF Beta 3 Polyclonal Antibody

TGF Beta 3 Antibody (18942-1-AP) in WB

Product Details

18942-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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