Invitrogen

TGF beta-3 Polyclonal Antibody

View all (16) TGF beta-3 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-85307

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human TGF-beta-3.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.86 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2792449

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (97%), Rat (97%), Pig (87%), Chicken (86%), Rhesus Monkey (100%), Bovine (85%).

Positive Control: mouse placenta, human TGFB3-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: FLJ16571; H-TGF-b-3; prepro-transforming growth factor beta-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein; transforming growth factor, beta 3

View more View less

Gene Aliases: ARVD; ARVD1; LDS5; RNHF; TGF-beta3; Tgfb-3; TGFB3

View more View less

UniProt ID: (Human) P10600

View more View less

Entrez Gene ID: (Human) 7043, (Mouse) 21809

View more View less

Function(s)
type II transforming growth factor beta receptor binding cytokine activity protein binding growth factor activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding identical protein binding protein heterodimerization activity transforming growth factor beta binding transforming growth factor beta receptor binding growth factor
Process(es)
activation of MAPK activity response to hypoxia in utero embryonic development platelet degranulation transforming growth factor beta receptor signaling pathway SMAD protein import into nucleus salivary gland morphogenesis female pregnancy aging negative regulation of DNA replication negative regulation of cell proliferation positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production cell growth positive regulation of bone mineralization negative regulation of transforming growth factor beta receptor signaling pathway mammary gland development response to progesterone positive regulation of collagen biosynthetic process response to laminar fluid shear stress wound healing regulation of cell proliferation odontogenesis uterine wall breakdown regulation of apoptotic process positive regulation of apoptotic process regulation of MAPK cascade negative regulation of neuron apoptotic process response to estrogen ossification involved in bone remodeling cell-cell junction organization positive regulation of DNA replication positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development digestive tract development embryonic neurocranium morphogenesis inner ear development positive regulation of protein secretion positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of cell division palate development face morphogenesis frontal suture morphogenesis positive regulation of SMAD protein import into nucleus SMAD protein signal transduction detection of hypoxia regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly embryo development organ morphogenesis growth cell development cellular response to growth factor stimulus
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support