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Product Details
X1484P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein derived from the extracellular domain of the chicken TGF III receptor protein. Protein shares significant homology with the mouse, rat and human sequences.
Conjugate
Form
Liquid
Concentration
0.5-2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Extraembryonic membranes from chick embryos.
Target Information
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ16571; H-TGF-b-3; TGF beta 3; Transforming growth factor; transforming growth factor beta precursor; Transforming growth factor beta-3 proprotein; transforming growth factor-beta3
Gene Aliases: TGF-beta-3; TGF-beta3; TGFB3
UniProt ID: (Chicken) P16047
Entrez Gene ID: (Chicken) 396438
response to hypoxia
cell activation
epithelial to mesenchymal transition involved in endocardial cushion formation
negative regulation of cell adhesion
transforming growth factor beta receptor signaling pathway
nervous system development
salivary gland morphogenesis
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of macrophage cytokine production
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
response to progesterone
positive regulation of collagen biosynthetic process
regulation of cell proliferation
ossification involved in bone remodeling
cell-cell junction organization
positive regulation of transcription, DNA-templated
spleen development
embryonic digestive tract development
positive regulation of cell division
cardiac epithelial to mesenchymal transition
face morphogenesis
SMAD protein signal transduction
detection of hypoxia
mesenchyme migration
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