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This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 gene.
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Protein Aliases: homeobox protein TGIF2; OTTHUMP00000030849; TGFB-induced factor homeobox 2-like 1
Gene Aliases: RGD1560115; RGD1564927; Tgif2l1
Entrez Gene ID: (Rat) 499929
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