Proteintech

TGM2 Polyclonal Antibody

TGM2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TGM2 Antibody (15100-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 15100-1-AP) (TGM2 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

TGM2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15100-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TGM2 Fusion Protein Ag7439 (1-349 aa encoded by BC003551)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEELVLER CDLELETNGR DHHTADLCRE KLVVRRGQPF WLTLHFEGRN YEASVDSLTF SVVTGPAPSQ EAGTKARFPL RDAVEEGDWT ATVVDQQDCT LSLQLTTPAN APIGLYRLSL EASTGYQGSS FVLGHFILLF NAWCPADAVY LDSEEERQEY VLTQQGFIYQ GSAKFIKNIP WNFGQFEDGI LDICLILLDV NPKFLKNAGR DCSRRSSPVY VGRVVSGMVN CNDDQGVLLG RWDNNYGDGV SPMSWIGSVD ILRRWKNHGC QRVKYGQCWV FAAVACTVLR CLGIPTRVVT NYNSAHDQNS NLLIEYFRNE FGEIQGDKSE MIWNFHCWVE SWMTRPDLQP (1-349 aa encoded by BC003551)

Target Information

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells.

Frontiers in endocrinology

González-Moro I,Rojas-Márquez H,Sebastian-delaCruz M,Mentxaka-Salgado J,Olazagoitia-Garmendia A,Mendoza LM,Lluch A,Fantuzzi F,Lambert C,Ares Blanco J,Marselli L,Marchetti P,Cnop M,Delgado E,Fernández-Real JM,Ortega FJ,Castellanos-Rubio A,Santin I

Mon Feb 27 00:00:00 EST 2023

Peroxiredoxins and Hypoxia-Inducible Factor-1α in Duodenal Tissue: Emerging Factors in the Pathophysiology of Pediatric Celiac Disease Patients.

Current issues in molecular biology

Köse FA,Pabuccuoglu A,Karakoyun M,Aydogdu S

Mon Feb 20 00:00:00 EST 2023

Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

Li X,Ma Y,Wu J,Ni M,Chen A,Zhou Y,Dai W,Chen Z,Jiang R,Ling Y,Yao Q,Chen W

Wed Mar 01 00:00:00 EST 2023

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Autophagy

Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 EST 2023

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Autophagy

Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 EST 2023

Damaged collagen detected by collagen hybridizing peptide as efficient diagnosis marker for early hepatic fibrosis.

Biochimica et biophysica acta. Gene regulatory mechanisms

Tao P,Liu J,Li Y,Zhang T,Wang F,Chang L,Li C,Ge X,Zuo T,Lu S,Ruan Y,Yang Z,Xu P

Thu Jun 01 00:00:00 EDT 2023

Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer.

Cellular oncology (Dordrecht)

Zhang S,Yao HF,Li H,Su T,Jiang SH,Wang H,Zhang ZG,Dong FY,Yang Q,Yang XM

Sun Oct 01 00:00:00 EDT 2023

Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer.

Cellular oncology (Dordrecht)

Zhang S,Yao HF,Li H,Su T,Jiang SH,Wang H,Zhang ZG,Dong FY,Yang Q,Yang XM

Sun Oct 01 00:00:00 EDT 2023

Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.

International immunopharmacology

Li Y,Sun H,Liu X,Hu Z,Jiang H,Guo H,Long X

Sun Jan 01 00:00:00 EST 2023

Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.

International immunopharmacology

Li Y,Sun H,Liu X,Hu Z,Jiang H,Guo H,Long X

Sun Jan 01 00:00:00 EST 2023

Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.

International immunopharmacology

Li Y,Sun H,Liu X,Hu Z,Jiang H,Guo H,Long X

Sun Jan 01 00:00:00 EST 2023

Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation.

International immunopharmacology

Li Y,Sun H,Liu X,Hu Z,Jiang H,Guo H,Long X

Sun Jan 01 00:00:00 EST 2023

TGM2 positively regulates myoblast differentiation via enhancing the mTOR signaling.

Biochimica et biophysica acta. Molecular cell research

Wang D,Zhao D,Li Y,Dai T,Liu F,Yan C

Tue Mar 01 00:00:00 EST 2022

TGM2 positively regulates myoblast differentiation via enhancing the mTOR signaling.

Biochimica et biophysica acta. Molecular cell research

Wang D,Zhao D,Li Y,Dai T,Liu F,Yan C

Tue Mar 01 00:00:00 EST 2022

6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.

Physiological research

Sokouti H,Mohajeri D,Nourazar MA

Wed Aug 31 00:00:00 EDT 2022

Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.

Scientific reports

Mitachi K,Ariake K,Shima H,Sato S,Miura T,Maeda S,Ishida M,Mizuma M,Ohtsuka H,Kamei T,Igarashi K,Unno M

Mon Mar 22 00:00:00 EDT 2021

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment.

Journal of experimental & clinical cancer research : CR

Ye D,Xu H,Xia H,Zhang C,Tang Q,Bi F

Tue May 18 00:00:00 EDT 2021

TGFβ-1 Induced Cross-Linking of the Extracellular Matrix of Primary Human Dermal Fibroblasts.

International journal of molecular sciences

Semkova ME,Hsuan JJ

Wed Jan 20 00:00:00 EST 2021

Immune subtyping for pancreatic cancer with implication in clinical outcomes and improving immunotherapy.

Cancer cell international

Liu J,Liu Q,Zhang X,Cui M,Li T,Zhang Y,Liao Q

Fri Feb 26 00:00:00 EST 2021

Immune subtyping for pancreatic cancer with implication in clinical outcomes and improving immunotherapy.

Cancer cell international

Liu J,Liu Q,Zhang X,Cui M,Li T,Zhang Y,Liao Q

Fri Feb 26 00:00:00 EST 2021

Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF-κB Signaling.

Journal of immunology research

Hou Y,Xiao X,Yu W,Qi S

Mon Jan 24 00:00:00 EST 2022

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

Nature communications

Wang C,Li Y,Yan S,Wang H,Shao X,Xiao M,Yang B,Qin G,Kong R,Chen R,Zhang N

Mon Jun 22 00:00:00 EDT 2020

Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.

Food & function

Wang J,Xu H,Cheng X,Yang J,Yan Z,Ma H,Zhao Y,Ommati MM,Manthari RK,Wang J

Wed Jan 29 00:00:00 EST 2020

AFF1 inhibits adipogenic differentiation via targeting TGM2 transcription.

Cell proliferation

Chen Y,Wang Y,Lin W,Sheng R,Wu Y,Xu R,Zhou C,Yuan Q

Mon Jun 01 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein G(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase 2; TGase C; TGase H; TGase II; TGase-2; TGase-H; TGC; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG

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Gene Aliases: G[a]h; TG(C); TG2; TGase2; TgaseII; TGC; TGM2; tTG; tTGas

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UniProt ID: (Human) P21980, (Rat) Q9WVJ6, (Mouse) P21981

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Entrez Gene ID: (Human) 7052, (Rat) 56083, (Mouse) 21817

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Function(s)

protein-glutamine gamma-glutamyltransferase activity protein binding metal ion binding GTP binding enzyme binding protein domain specific binding calcium ion binding transaminase activity transferase activity transferase activity, transferring acyl groups transferase

Process(es)

phospholipase C-activating G-protein coupled receptor signaling pathway peptide cross-linking negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of apoptotic process apoptotic cell clearance positive regulation of cell adhesion positive regulation of mitochondrial calcium ion concentration branching involved in salivary gland morphogenesis salivary gland cavitation blood vessel remodeling isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response protein homooligomerization positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway G-protein coupled receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TGM2 Polyclonal Antibody

TGM2 Antibody (15100-1-AP) in IHC (P)

Product Details

15100-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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