Product References
Deregulation of Autophagy and Apoptosis in Patients with Myelodysplastic Syndromes: Implications for Disease Development and Progression.
Current issues in molecular biology
Tsekoura G,Agathangelidis A,Kontandreopoulou CN,Taliouraki A,Mporonikola G,Stavropoulou M,Diamantopoulos PT,Viniou NA,Aleporou V,Papassideri I,Kollia P
MA5-12739 was used in Western Blotting to investigate the role of autophagy and apoptosis in the pathogenesis and progression of Myelodysplastic neoplasms.
Mon May 08 00:00:00 EDT 2023
Deregulation of Autophagy and Apoptosis in Patients with Myelodysplastic Syndromes: Implications for Disease Development and Progression.
Current issues in molecular biology
Tsekoura G,Agathangelidis A,Kontandreopoulou CN,Taliouraki A,Mporonikola G,Stavropoulou M,Diamantopoulos PT,Viniou NA,Aleporou V,Papassideri I,Kollia P
MA5-12739 was used in Western Blotting to investigate the role of autophagy and apoptosis in the pathogenesis and progression of Myelodysplastic neoplasms.
Mon May 08 00:00:00 EDT 2023
Comparative Profiling of TG2 and Its Effectors in Human Relapsing Remitting and Progressive Multiple Sclerosis.
Biomedicines
Pearse DD,Hefley AB,Morales AA,Ghosh M
MA5-12739 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show that the correlation of strong TG2 induction in either RRMS or PMS with some of its binding partners but not others implicates potentially different roles for TG2 in disparate MS forms that may warrant further investigation.
Thu May 26 00:00:00 EDT 2022
Transglutaminase 2: Development of therapeutic antibodies reveals four inhibitory epitopes and confirms extracellular function in fibrotic remodelling.
British journal of pharmacology
Maamra M,Benayad OM,Matthews D,Kettleborough C,Atkinson J,Cain K,Bon H,Brand H,Parkinson M,Watson PF,Johnson TS
MA5-12739 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to develop a high affinity TG2-specific antibody against extracellular TG2 activity, with characteristics suitable for therapeutic development.
Wed Jun 01 00:00:00 EDT 2022
An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress.
Molecular cell
Nüchel J,Tauber M,Nolte JL,Mörgelin M,Türk C,Eckes B,Demetriades C,Plomann M
Published figure using TGM2 monoclonal antibody (Product # MA5-12739) in Western Blot
Thu Aug 19 00:00:00 EDT 2021
Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy.
Cells
Alonzi T,Aiello A,Petrone L,Najafi Fard S,D'Eletto M,Falasca L,Nardacci R,Rossin F,Delogu G,Castilletti C,Capobianchi MR,Ippolito G,Piacentini M,Goletti D
MA5-12739 was used in Western Blotting to illustrate that cysteamine and cystamine exert direct antiviral actions against SARS-CoV-2 and have in vitro immunomodulatory effects, thus providing a rational to test these compounds as a novel therapy for COVID-19.
Fri Dec 24 00:00:00 EST 2021
Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy.
Cells
Alonzi T,Aiello A,Petrone L,Najafi Fard S,D'Eletto M,Falasca L,Nardacci R,Rossin F,Delogu G,Castilletti C,Capobianchi MR,Ippolito G,Piacentini M,Goletti D
MA5-12739 was used in Western Blotting to illustrate that cysteamine and cystamine exert direct antiviral actions against SARS-CoV-2 and have in vitro immunomodulatory effects, thus providing a rational to test these compounds as a novel therapy for COVID-19.
Fri Dec 24 00:00:00 EST 2021
Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy.
Cells
Alonzi T,Aiello A,Petrone L,Najafi Fard S,D'Eletto M,Falasca L,Nardacci R,Rossin F,Delogu G,Castilletti C,Capobianchi MR,Ippolito G,Piacentini M,Goletti D
MA5-12739 was used in Western Blotting to illustrate that cysteamine and cystamine exert direct antiviral actions against SARS-CoV-2 and have in vitro immunomodulatory effects, thus providing a rational to test these compounds as a novel therapy for COVID-19.
Fri Dec 24 00:00:00 EST 2021
Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers.
Experimental & molecular medicine
Cho SY,Oh Y,Jeong EM,Park S,Lee D,Wang X,Zeng Q,Qin H,Hu F,Gong H,Liu X,Zhang G,Na D,Lee J,Chae J,Suh YS,Kong SH,Lee HJ,Kim JI,Park H,Zhang C,Yang HK,Lee C
MA5-12739 was used in Immunohistochemistry to show transglutaminase 2 is a regulator of the gastric cancer microenvironment.
Fri May 01 00:00:00 EDT 2020
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Viruses
Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U
MA5-12739 was used in Immunohistochemistry to study whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Mon May 25 00:00:00 EDT 2020
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Viruses
Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U
MA5-12739 was used in Immunohistochemistry to study whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Mon May 25 00:00:00 EDT 2020
Zika Virus with Increased CpG Dinucleotide Frequencies Shows Oncolytic Activity in Glioblastoma Stem Cells.
Viruses
Trus I,Berube N,Jiang P,Rak J,Gerdts V,Karniychuk U
MA5-12739 was used in Immunohistochemistry to study whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Mon May 25 00:00:00 EDT 2020
Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma.
International journal of molecular sciences
Lee SH,Kang JH,Ha JS,Lee JS,Oh SJ,Choi HJ,Song J,Kim SY
MA5-12739 was used in Western Blotting to find that TGase 2-mediated p53 depletion increased the availability of p300 for HIF-1α-p300 binding.
Fri Jul 17 00:00:00 EDT 2020
Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma.
International journal of molecular sciences
Lee SH,Kang JH,Ha JS,Lee JS,Oh SJ,Choi HJ,Song J,Kim SY
MA5-12739 was used in Western Blotting to find that TGase 2-mediated p53 depletion increased the availability of p300 for HIF-1α-p300 binding.
Fri Jul 17 00:00:00 EDT 2020
Transglutaminase 2-Mediated p53 Depletion Promotes Angiogenesis by Increasing HIF-1α-p300 Binding in Renal Cell Carcinoma.
International journal of molecular sciences
Lee SH,Kang JH,Ha JS,Lee JS,Oh SJ,Choi HJ,Song J,Kim SY
MA5-12739 was used in Western Blotting to find that TGase 2-mediated p53 depletion increased the availability of p300 for HIF-1α-p300 binding.
Fri Jul 17 00:00:00 EDT 2020
Tissue transglutaminase_variant 2-transduced mesenchymal stem cells and their chondrogenic potential.
Biotechnology and bioengineering
Calikoglu Koyuncu AC,Nayman AH,Telci D,Torun Kose G
MA5-12739 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry to design a study to improve cartilage tissue regeneration by expressing tissue transglutaminase variant 2 (TGM2_v2) in mesenchymal stem cells (MSC) derived from bone marrow of rats.
Mon Jun 01 00:00:00 EDT 2020
3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations.
Biomaterials
Court M,Malier M,Millet A
MA5-12739 was used in Western Blot to give the molecular basis for assessing collagen induced immunomodulation of human macrophages in various physiological and pathological contexts such as cancer.
Mon Jul 01 00:00:00 EDT 2019
Integrated Molecular Characterization of Uterine Carcinosarcoma.
Cancer cell
Cherniack AD,Shen H,Walter V,Stewart C,Murray BA,Bowlby R,Hu X,Ling S,Soslow RA,Broaddus RR,Zuna RE,Robertson G,Laird PW,Kucherlapati R,Mills GB,Weinstein JN,Zhang J,Akbani R,Levine DA
MA512739 was used in reverse phase protein array to characterize the molecular identity of uterine carcinosarcomas.
Mon Mar 13 00:00:00 EDT 2017
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Cell systems
Hill SM,Nesser NK,Johnson-Camacho K,Jeffress M,Johnson A,Boniface C,Spencer SE,Lu Y,Heiser LM,Lawrence Y,Pande NT,Korkola JE,Gray JW,Mills GB,Mukherjee S,Spellman PT
MA512739 was used in western blot to analyze the context specificity of signaling networks within a causal conceptual framework using reverse-phase protein array time-course assays and network analysis approaches
Wed Jan 25 00:00:00 EST 2017
Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease.
Mucosal immunology
Di Niro R,Snir O,Kaukinen K,Yaari G,Lundin KE,Gupta NT,Kleinstein SH,Cols M,Cerutti A,Mäki M,Shlomchik MJ,Sollid LM
MA5-12739 was used in immunohistochemistry - frozen section to characterize celiac disease and responsive population dynamics and wide seeding in transglutaminase-2-specific plasma cells in the duodenal lamina propria
Fri Jan 01 00:00:00 EST 2016
Protein cross-linking by chlorinated polyamines and transglutamylation stabilizes neutrophil extracellular traps.
Cell death & disease
Csomós K,Kristóf E,Jakob B,Csomós I,Kovács G,Rotem O,Hodrea J,Bagoly Z,Muszbek L,Balajthy Z,Csősz É,Fésüs L
MA512739 was used in immunocytochemistry and western blot to discover factors that contribution to the formation of neutrophil extracellular trap
Thu Aug 11 00:00:00 EDT 2016
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Oncotarget
Altuntas S,Rossin F,Marsella C,D'Eletto M,Diaz-Hidalgo L,Farrace MG,Campanella M,Antonioli M,Fimia GM,Piacentini M
MA5-12739 was used in immunoprecipitation and western blot to study interplay in autophagy regulation between transglutaminase type 2 and pyruvate kinase isoenzyme M2
Tue Dec 29 00:00:00 EST 2015
Transglutaminase 2--a novel inhibitor of adipogenesis.
Cell death & disease
Myneni VD,Melino G,Kaartinen MT
MA5-12739 was used in western blot to examine TG2 function during adipocyte differentiation
Thu Aug 27 00:00:00 EDT 2015
Intestinal-mucosa anti-transglutaminase antibody assays to test for genetic gluten intolerance.
Cellular & molecular immunology
Quaglia S,De Leo L,Ziberna F,Vatta S,Villanacci V,Granzotto M,Petix V,Martelossi S,Di Leo G,Torelli L,Not T
MA5-12739 was used in immunohistochemistry to develop assays for the detection of genetic gluten intolerence based on the measurement of intestinal epithelial transglutaminase
Sat Nov 01 00:00:00 EDT 2014
TGM2: a cell surface marker in esophageal adenocarcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Leicht DT,Kausar T,Wang Z,Ferrer-Torres D,Wang TD,Thomas DG,Lin J,Chang AC,Lin L,Beer DG
MA5-12739 was used in immunohistochemistry and western blot to study the value of cell surface transglutaminase-2 as a biomarker for the early detection of esophageal adenocarcinomas
Sun Jun 01 00:00:00 EDT 2014
Transglutaminase 2 is essential for adherence of Porphyromonas gingivalis to host cells.
Proceedings of the National Academy of Sciences of the United States of America
Boisvert H,Lorand L,Duncan MJ
MA5-12739 was used in immunocytochemistry and western blot to study the role of cell-surface transglutaminase-2 in the host-cell adhesion of Porphyromonas gingivalis
Tue Apr 08 00:00:00 EDT 2014
Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1.
Redox biology
Lee DY,Chang GD
MA5-12739 was used in western blot to study the regulatory mechanisms underlying the transglutaminase-2-mediated activation of glyoxylase-1 in response to cellular methylglyoxal challenge
Tue Jun 16 00:00:00 EDT 2015
Celiac disease patient IgA antibodies induce endothelial adhesion and cell polarization defects via extracellular transglutaminase 2.
Cellular and molecular life sciences : CMLS
Nadalutti CA,Korponay-Szabo IR,Kaukinen K,Griffin M,Mäki M,Lindfors K
MA5-12739 was used in ELISA and western blot to study the role of endothelial cell transglutaminase-2 secretion in the mechanism by which IgA antibodies from patients with celiac disease disrupt endothelial cell ahesion and polarization
Tue Apr 01 00:00:00 EDT 2014
Lack of transglutaminase 2 diminished T-cell responses in mice.
Immunology
Kim JH,Hong JM,Jeong EM,Lee WJ,Kim HR,Kang JS,Kim IG,Hwang YI
MA5-12739 was used in immunocytochemistry and western blot to study the role of transglutaminase-2 in murine T-cell responses
Tue Jul 01 00:00:00 EDT 2014
The kiwi fruit peptide kissper displays anti-inflammatory and anti-oxidant effects in in-vitro and ex-vivo human intestinal models.
Clinical and experimental immunology
Ciacci C,Russo I,Bucci C,Iovino P,Pellegrini L,Giangrieco I,Tamburrini M,Ciardiello MA
MA5-12739 was used in immunohistochemistry and western blot to use LPS-challenge to study the anti-inflammatory and anti-oxidant properties of the kissper peptide from Kiwi fruit in models of the human intestine
Sat Mar 01 00:00:00 EST 2014
Sampling of proximal and distal duodenal biopsies in the diagnosis and monitoring of celiac disease.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Caruso R,Marafini I,Del Vecchio Blanco G,Fina D,Paoluzi OA,Colantoni A,Sedda S,Pallone F,Monteleone G
MA5-12739 was used in immunohistochemistry to evaluate the ability to diagnose celiac disease using biopsy samples from the proximal and distal duodenum
Tue Apr 01 00:00:00 EDT 2014
Increased expression of transglutaminase 2 drives glycolytic metabolism in renal carcinoma cells.
Amino acids
Ku BM,Lee CH,Lee SH,Kim SY
MA5-12739 was used in immunocytochemistry and western blot to study the mechanism by which transglutaminase-2 expresson levels modulate glycolysis in renal carcinoma cells
Sun Jun 01 00:00:00 EDT 2014
Transglutaminase 2 and phospholipase A₂ interactions in the inflammatory response in human Thp-1 monocytes.
Amino acids
Currò M,Ferlazzo N,Risitano R,Condello S,Vecchio M,Caccamo D,Ientile R
MA5-12739 was used in immunoprecipitation and western blot to study inflammatory responses to LPS-stumulation of human THP-1 monocytes and the role of interactions between transglutaminase-2 and phospholipase A2
Sat Mar 01 00:00:00 EST 2014
Exercise, vascular stiffness, and tissue transglutaminase.
Journal of the American Heart Association
Steppan J,Sikka G,Jandu S,Barodka V,Halushka MK,Flavahan NA,Belkin AM,Nyhan D,Butlin M,Avolio A,Berkowitz DE,Santhanam L
MA5-12739 was used in immunohistochemistry to study the effects of aerobic exercise on NO signaling, transglutaminase-2 activity and vascular stiffness in a rat model
Thu Apr 10 00:00:00 EDT 2014
Gliadin does not induce mucosal inflammation or basophil activation in patients with nonceliac gluten sensitivity.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Bucci C,Zingone F,Russo I,Morra I,Tortora R,Pogna N,Scalia G,Iovino P,Ciacci C
MA5-12739 was used in immunohistochemistry to study whether gut mucosa from non-celiac patients with gluten-sensitivity displays inflammatory and immunological responses to gluten exposure
Tue Oct 01 00:00:00 EDT 2013
Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease.
Clinical immunology (Orlando, Fla.)
Byrne G,Freeley M,Feighery C,Whelan A,Long A
MA5-12739 was used in western blot to study the occurrence of anti-PKC-delta autoantibodies in coeliac disease and the significance of tissue transglutaminase-catalysed PKC-delta transamidation and polymerization
Mon Apr 01 00:00:00 EDT 2013
Transglutaminase-2 induces N-cadherin expression in TGF-β1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation.
European journal of cancer (Oxford, England : 1990)
Park MK,You HJ,Lee HJ,Kang JH,Oh SH,Kim SY,Lee CH
MA5-12739 was used in western blot to study the mechanism by which transglutaminase-2 induces the expression of N-cadherin in cells undergoing epithelial-mesenchymal transition in response to TGF-beta1
Wed May 01 00:00:00 EDT 2013
Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1.
Clinical nutrition (Edinburgh, Scotland)
D'Argenio G,Mazzone G,Ribecco MT,Lembo V,Vitaglione P,Guarino M,Morisco F,Napolitano M,Fogliano V,Caporaso N
MA5-12739 was used in western blot to study the role of TGF-beta downregulation in the mechanism by which a garlic extract protects against liver fibrosis
Mon Apr 01 00:00:00 EDT 2013
Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ku BM,Kim DS,Kim KH,Yoo BC,Kim SH,Gong YD,Kim SY
MA5-12739 was used in immunoprecipitation and western blot to study the mechanism by which inhibition of transglutaminase-2 promotes p53-dependent apoptosis in renal cell carcinoma
Sun Sep 01 00:00:00 EDT 2013
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.
Journal of immunology (Baltimore, Md. : 1950)
Iversen R,Di Niro R,Stamnaes J,Lundin KE,Wilson PC,Sollid LM
MA5-12739 was used in ELISA and flow cytometry to study N-terminal epitopes exposed only on soluble catalytically active transglutaminase-2 as the target of celiac disease auto-antibodies
Sat Jun 15 00:00:00 EDT 2013
Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.
Acta diabetologica
Russo L,Marsella C,Nardo G,Massignan T,Alessio M,Piermarini E,La Rosa S,Finzi G,Bonetto V,Bertuzzi F,Maechler P,Massa O
MA5-12739 was used in immunocytochemistry to identify substrates of transglutaminase-2 transamidation activity during first-phase insulin secretion in a pancreatic beta cell line
Fri Feb 01 00:00:00 EST 2013
Divergent results induced by different types of septic shock in transglutaminase 2 knockout mice.
Amino acids
Yoo H,Ahn ER,Kim SJ,Lee SH,Oh SH,Kim SY
MA5-12739 was used in western blot to study the different effect of septic shock induced by LPS and that induced by TNFalpha/actinomycin D in transglutaminase-2 knockout mice
Tue Jan 01 00:00:00 EST 2013
Anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase by modulating cytosolic Ca2+ homeostasis.
Amino acids
Caputo I,Lepretti M,Secondo A,Martucciello S,Paolella G,Sblattero D,Barone MV,Esposito C
MA5-12739 was used in blocking or activating experiment to study the mechanism by which anti-tissue transglutaminase antibodies activate intracellular tissue transglutaminase
Tue Jan 01 00:00:00 EST 2013
The role of TG2 in regulating S100A4-mediated mammary tumour cell migration.
PloS one
Wang Z,Griffin M
MA5-12739 was used in western blot to study transglutaminase 2-regulated S100A4-related mediated cell migration
Tue Aug 27 00:00:00 EDT 2013
Thioredoxin is involved in endothelial cell extracellular transglutaminase 2 activation mediated by celiac disease patient IgA.
PloS one
Antonella Nadalutti C,Korponay-Szabo IR,Kaukinen K,Wang Z,Griffin M,Mäki M,Lindfors K
MA5-12739 was used in ELISA to study the ability of IgA from celiac disease patients to activate endothelial cell transglutaminase-2 and the mechanistic role of thioredoxin
Wed Jun 11 00:00:00 EDT 2014
Type 1 diabetes is associated with enterovirus infection in gut mucosa.
Diabetes
Oikarinen M,Tauriainen S,Oikarinen S,Honkanen T,Collin P,Rantala I,Mäki M,Kaukinen K,Hyöty H
MA5-12739 was used in immunohistochemistry to study the relationship between gut mucosal enterovirus infection and type I diabetes
Thu Mar 01 00:00:00 EST 2012
Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.
Breast cancer research : BCR
Kumar A,Xu J,Sung B,Kumar S,Yu D,Aggarwal BB,Mehta K
MA5-12739 was used in immunocytochemistry and western blot to study the role of the transglutaminase-2 GTP-binding domain in promoting mammary epithelial cell epithelial-to-mesenchymal transition
Fri Jan 06 00:00:00 EST 2012
Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.
Journal of cellular physiology
Zemskov EA,Mikhailenko I,Smith EP,Belkin AM
MA5-12739 was used in immunocytochemistry to study PDGF/PDGFR--driven signaling and phenotypic modulation of vascular smooth muscle cells and the role played by tissue transglutaminase
Tue May 01 00:00:00 EDT 2012
Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis.
Arthritis research & therapy
Lauzier A,Charbonneau M,Paquette M,Harper K,Dubois CM
MA5-12739 was used in immunocytochemistry to study the role of transglutaminase 2 in cartilage degradation in rheumatid arthritis
Wed Jul 04 00:00:00 EDT 2012
Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
D'Argenio G,Mazzone G,Tuccillo C,Ribecco MT,Graziani G,Gravina AG,Caserta S,Guido S,Fogliano V,Caporaso N,Romano M
MA5-12739 was used in western blot to study the effects of polyphenols extracted from apple on disease biomarkers and disease severity in a rat model of ulcerative colitis
Sun Jul 01 00:00:00 EDT 2012
Expression of tissue transglutaminase on primary olfactory ensheathing cells cultures exposed to stress conditions.
Neuroscience research
Campisi A,Spatuzza M,Russo A,Raciti G,Vanella A,Stanzani S,Pellitteri R
MA5-12739 was used in immunocytochemistry and western blot to study the effect of stress on the expression of transglutaminase-2 by olfactory ensheathing cells
Sun Apr 01 00:00:00 EDT 2012
Immunological effects of transglutaminase-treated gluten in coeliac disease.
Human immunology
Elli L,Roncoroni L,Hils M,Pasternack R,Barisani D,Terrani C,Vaira V,Ferrero S,Bardella MT
MA5-12739 was used in immunohistochemistry to study the immunological effects of transglutaminase-treated gluten in coeliac disease
Mon Oct 01 00:00:00 EDT 2012
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
The Journal of biological chemistry
Ai L,Skehan RR,Saydi J,Lin T,Brown KD
MA5-12739 was used in western blot to study the molecular mechanisms regulating basal and DNA damage-induced transglutaminase-2 expression
Fri May 25 00:00:00 EDT 2012
Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Verhaar R,Andringa G,Bol JG,Cras P,Shan L,Hoozemans JJ,Drukarch B
MA5-12739 was used in immunohistochemistry to study the presence of tissue transglutaminase in melanized neurons in Parkinson's disease brain
Tue Mar 01 00:00:00 EST 2011
Persistently positive gliadin antibodies without transglutaminase antibodies in the elderly: gluten intolerance beyond coeliac disease.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Ruuskanen A,Luostarinen L,Collin P,Krekelä I,Patrikainen H,Tillonen J,Laurila K,Haimila K,Partanen J,Mäki M,Valve R,Kaukinen K
MA5-12739 was used in immunohistochemistry to study the mechanism for gluten intolerance
Sat Oct 01 00:00:00 EDT 2011
Early developing celiac disease in children with cerebral palsy.
Journal of pediatric gastroenterology and nutrition
Stenberg R,Kaukinen K,Bengtsson M,Lindberg E,Dahle C
MA5-12739 was used in immunohistochemistry to study early developing celiac disease in children with cerebral palsy
Thu Dec 01 00:00:00 EST 2011
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
The Journal of biological chemistry
Chiang NY,Hsiao CC,Huang YS,Chen HY,Hsieh IJ,Chang GW,Lin HH
MA5-12739 was used in flow cytometry and western blot to elucidate the cellular functions of GPR56 receptor and how they contribute to bilateral frontoparietal polymicrogyria.
Fri Apr 22 00:00:00 EDT 2011
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
The Journal of biological chemistry
Chiang NY,Hsiao CC,Huang YS,Chen HY,Hsieh IJ,Chang GW,Lin HH
MA5-12739 was used in flow cytometry and western blot to elucidate the cellular functions of GPR56 receptor and how they contribute to bilateral frontoparietal polymicrogyria.
Fri Apr 22 00:00:00 EDT 2011
Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.
Molecular cancer
Tatsukawa H,Sano T,Fukaya Y,Ishibashi N,Watanabe M,Okuno M,Moriwaki H,Kojima S
MA5-12739 was used in western blot to study the ability of acyclic retinoid to induce both caspase-3-dependent and transglutaminase-dependent apoptotic pathways in hepatocellular carcinoma cells
Sun Jan 09 00:00:00 EST 2011
Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells.
Laboratory investigation; a journal of technical methods and pathology
Prunotto M,Compagnone A,Bruschi M,Candiano G,Colombatto S,Bandino A,Petretto A,Moll S,Bochaton-Piallat ML,Gabbiani G,Dimuccio V,Parola M,Citti L,Ghiggeri G
MA5-12739 was used in immunocytochemistry to investigate the effect of endocellular polyamine on epithelial-to-mesenchymal transition process
Tue Jun 01 00:00:00 EDT 2010
Intestinal transglutaminase 2 specific antibody deposits in non-responsive coeliac disease.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Koskinen O,Lindfors K,Collin P,Peräaho M,Laurila K,Woolley N,Partanen J,Mäki M,Kaukinen K
MA5-12739 was used in immunohistochemistry to evaluate an immune method for the identification of non-responsive coeliac disease
Fri Oct 01 00:00:00 EDT 2010
Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5.
FEBS letters
Frese-Schaper M,Schardt JA,Sakai T,Carboni GL,Schmid RA,Frese S
MA5-12739 was used in western blot to investigate the effect of tissue transglutaminase blockade on specific cancer cell apoptosis
Fri Jul 02 00:00:00 EDT 2010
The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis.
Cell death and differentiation
Malorni W,Farrace MG,Matarrese P,Tinari A,Ciarlo L,Mousavi-Shafaei P,D'Eletto M,Di Giacomo G,Melino G,Palmieri L,Rodolfo C,Piacentini M
MA5-12739 was used in immunocytochemistry to investigate the relation between adenine nucleotide translocator 1 and transglutaminase
Sun Nov 01 00:00:00 EDT 2009
Glucosamine is an effective chemo-sensitizer via transglutaminase 2 inhibition.
Cancer letters
Kim DS,Park KS,Jeong KC,Lee BI,Lee CH,Kim SY
MA5-12739 was used in western blot to study the use of glucosamine to sensitization cells to chemotherapy by inhibition of transglutaminase-2
Sun Jan 18 00:00:00 EST 2009
Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain.
Brain pathology (Zurich, Switzerland)
Wilhelmus MM,Grunberg SC,Bol JG,van Dam AM,Hoozemans JJ,Rozemuller AJ,Drukarch B
MA5-12739 was used in immunohistochemistry to study the role of transglutaminases and transglutaminase-catalyzed cross-links in Alzheimer's disease pathology
Thu Oct 01 00:00:00 EDT 2009
Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.
Osteoarthritis and cartilage
Huebner JL,Johnson KA,Kraus VB,Terkeltaub RA
MA5-12739 was used in immunohistochemistry to study transglutaminase-2 as a marker of chondrocyte hypertrophy and disease severity in a model of osteoarthritis
Sat Aug 01 00:00:00 EDT 2009
Tissue transglutaminase expression in celiac mucosa: an immunohistochemical study.
Virchows Archiv : an international journal of pathology
Gorgun J,Portyanko A,Marakhouski Y,Cherstvoy E
MA5-12739 was used in immunohistochemistry to investigate the expression of tissue transglutaminase in celiac mucosa
Thu Oct 01 00:00:00 EDT 2009
Fibroblastic reticular cell infection by hemorrhagic fever viruses.
Immunotherapy
Steele KE,Anderson AO,Mohamadzadeh M
MA5-12739 was used in immunohistochemistry to investigate the changes of fibroblastic reticular cell function during hemorrhagic fever virus infection
Sun Mar 01 00:00:00 EST 2009
Effects of post-translational modifications catalysed by pollen transglutaminase on the functional properties of microtubules and actin filaments.
The Biochemical journal
Del Duca S,Serafini-Fracassini D,Bonner P,Cresti M,Cai G
MA5-12739 was used in western blot to study the effect of pollen transglutaminase on the functional properties of microtubules and actin filaments
Sun Mar 15 00:00:00 EDT 2009
Positive auto-regulation of MYCN in human neuroblastoma.
Biochemical and biophysical research communications
Suenaga Y,Kaneko Y,Matsumoto D,Hossain MS,Ozaki T,Nakagawara A
MA5-12739 was used in western blot to study the auto-regulation of the MYCN oncogene in human neuroblastoma
Fri Dec 04 00:00:00 EST 2009
Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase.
Annals of neurology
Hadjivassiliou M,Aeschlimann P,Strigun A,Sanders DS,Woodroofe N,Aeschlimann D
MA5-12739 was used in immunohistochemistry to study autoantibodies in gluten ataxia that recognize a novel neuronal transglutaminase
Mon Sep 01 00:00:00 EDT 2008
Effect of acetylcholine precursors on proliferation and differentiation of astroglial cells in primary cultures.
Neurochemical research
Bramanti V,Campisi A,Tomassoni D,Li Volti G,Caccamo D,Cannavò G,Currò M,Raciti G,Napoli M,Ientile R,Vanella A,Amenta F,Avola R
MA5-12739 was used in western blot to study the role of acetylcholine precursors on astroglial cell differentiation and proliferation
Mon Dec 01 00:00:00 EST 2008
Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation.
Placenta
Li HY,Shen JT,Chang SP,Hsu WL,Sung YJ
MA5-12739 was used in western blot to examine the role of calcitonin on trophoblast cells during implantation
Tue Jan 01 00:00:00 EST 2008
Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling.
The Journal of biological chemistry
Telci D,Wang Z,Li X,Verderio EA,Humphries MJ,Baccarini M,Basaga H,Griffin M
MA5-12739 was used in western blot to study the mechanism by which the fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion
Fri Jul 25 00:00:00 EDT 2008
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.
Chemistry & biology
Lai TS,Liu Y,Tucker T,Daniel KR,Sane DC,Toone E,Burke JR,Strittmatter WJ,Greenberg CS
MA5-12739 was used in western blot to screen for small molecule inhibitors of human tissue transglutaminase in existing drug libraries
Mon Sep 22 00:00:00 EDT 2008
Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivation.
Cancer research
Kim DS,Park SS,Nam BH,Kim IH,Kim SY
MA5-12739 was used in western blot to study the reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-kappaB inactivation
Wed Nov 15 00:00:00 EST 2006
In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes.
PLoS medicine
Zanoni G,Navone R,Lunardi C,Tridente G,Bason C,Sivori S,Beri R,Dolcino M,Valletta E,Corrocher R,Puccetti A
MA5-12739 was used in western blot to investigate the molecular basis of celiac disease
Fri Sep 01 00:00:00 EDT 2006
SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix.
International journal of cancer
Chlenski A,Liu S,Guerrero LJ,Yang Q,Tian Y,Salwen HR,Zage P,Cohn SL
MA5-12739 was used in western blot to study the role of SPARC expression in impaired tumor growth, inhibited angiogenesis and extracellular matrix changes
Sun Jan 15 00:00:00 EST 2006
Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation.
FEBS letters
Strnad P,Siegel M,Toivola DM,Choi K,Kosek JC,Khosla C,Omary MB
MA5-12739 was used in western blot to study the effect of transglutaminase inhibition on drug-primed liver hypertrophy and Mallory body formation
Mon Apr 17 00:00:00 EDT 2006
Characterization of purified rat testicular transglutaminase and age-dependent changes of the enzyme activities.
The international journal of biochemistry & cell biology
Wu YW,Lai WF,Tsai YH
MA5-12739 was used in western blot to study the enzymatic properties of purified rat testicular transglutaminase
Tue Feb 01 00:00:00 EST 2005
Nuclear factor-kappab activation is associated with glutamate-evoked tissue transglutaminase up-regulation in primary astrocyte cultures.
Journal of neuroscience research
Caccamo D,Campisi A,Currò M,Aguennouz M,Li Volti G,Avola R,Ientile R
MA5-12739 was used in western blot to study the role of NFkB activation in glutamate-evoked tissue transglutaminase up-regulation in primary astrocytes
Thu Dec 15 00:00:00 EST 2005
Distinct pH modulation for dual function of Galphah (transglutaminase II).
Journal of biochemistry
Chae KY,Kim JH,Park WJ,Kim YG,Yun HY,Kwon NS,Im MJ,Baek KJ
MA5-12739 was used in immunoprecipitation to study the role of pH in modulating the dual function of Galphah (transglutaminase II)
Tue Mar 01 00:00:00 EST 2005
Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells.
Archives of pharmacal research
Suh MD,Park CH,Kim SS,Kil MO,Lee GH,Johnson GV,Chun W
MA5-12739 was used in immunoprecipitation to study whether tissue transglutaminase plays a role in alpha-synuclein aggregation in neuroblastoma cells
Sun Aug 01 00:00:00 EDT 2004
Excitotoxin-induced changes in transglutaminase during differentiation of cerebellar granule cells.
Amino acids
Caccamo D,Currò M,Cusumano G,Crisafulli G,Ientile R
MA5-12739 was used in ELISA to study the role of excitotoxin in transglutaminase expression during differentiation of cerebellar granule cells
Mon Mar 01 00:00:00 EST 2004
Transglutaminase activity and transglutaminase mRNA transcripts in gerbil brain ischemia.
Neuroscience letters
Ientile R,Caccamo D,Marciano MC,Currò M,Mannucci C,Campisi A,Calapai G
MA5-12739 was used in western blot to study the expression and activity of transglutaminase in gerbil brain ischemia.
Thu Jun 10 00:00:00 EDT 2004
Expression of apoptosis-related proteins in rat with induced colitis.
International journal of colorectal disease
D'Argenio G,Farrace MG,Cosenza V,De Ritis F,Della Valle N,Manguso F,Piacentini M
MA5-12739 was used in immunohistochemistry to study the expression of apoptosis-related proteins in a model of colitis
Wed Sep 01 00:00:00 EDT 2004
Tissue transglutaminase is a multifunctional BH3-only protein.
The Journal of biological chemistry
Rodolfo C,Mormone E,Matarrese P,Ciccosanti F,Farrace MG,Garofano E,Piredda L,Fimia GM,Malorni W,Piacentini M
MA5-12739 was used in immunoprecipitation and western blot to investigate the interaction of tissue transglutaminase with proteins that regulate apoptosis
Fri Dec 24 00:00:00 EST 2004
Transglutaminase 2 induces nuclear factor-kappaB activation via a novel pathway in BV-2 microglia.
The Journal of biological chemistry
Lee J,Kim YS,Choi DH,Bang MS,Han TR,Joh TH,Kim SY
MA5-12739 was used in western blot to study the mechanism by which transglutaminase 2 induces nuclear factor-kappaB activation in microglia cells
Fri Dec 17 00:00:00 EST 2004
Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells.
Journal of biochemistry and molecular biology
Kweon SM,Lee ZW,Yi SJ,Kim YM,Han JA,Paik SG,Ha SS
MA5-12739 was used in western blot to study the interplay between tissue transglutaminase and TNF-alpha in the cell death of SH-SY5Y neuroblastoma cells
Wed Mar 31 00:00:00 EST 2004
In patients with dermatitis herpetiformis distribution of transglutaminase in cutaneous tissue does not differ from controls.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Biagi F,Bassi E,Ardigó M,Vignini MA,Caravaggi M,Borroni G,Corazza GR
MA5-12739 was used in immunohistochemistry to study the localization of tissue transglutaminase in the skin of dermatitis herpetiformis patients
Wed Jan 01 00:00:00 EST 2003
Glutamate-induced increases in transglutaminase activity in primary cultures of astroglial cells.
Brain research
Campisi A,Caccamo D,Raciti G,Cannavò G,Macaione V,Currò M,Macaione S,Vanella A,Ientile R
MA5-12739 was used in western blot to study glutamate-induced increases in transglutaminase activity in primary cultures of astroglial cells
Fri Jul 18 00:00:00 EDT 2003
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.
The Journal of biological chemistry
Ladd PA,Du L,Capdevila JH,Mernaugh R,Keeney DS
MA5-12739 was used in western blot to study the activation of transglutaminases by epoxyeicosatrienoic acids and its role in epidermal keratinocyte cornification
Fri Sep 12 00:00:00 EDT 2003
Bone-specific antibodies in sera from patients with celiac disease: characterization and implications in osteoporosis.
Journal of clinical immunology
Sugai E,Cherñavsky A,Pedreira S,Smecuol E,Vazquez H,Niveloni S,Mazure R,Mauriro E,Rabinovich GA,Bai JC
MA5-12739 was used in immunohistochemistry to study circulating auto-antibodies targeting bone tissue transglutaminase in celiac disease patients and the significance for osteoporosis
Fri Nov 01 00:00:00 EST 2002
Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress.
Journal of neurochemistry
Piacentini M,Farrace MG,Piredda L,Matarrese P,Ciccosanti F,Falasca L,Rodolfo C,Giammarioli AM,Verderio E,Griffin M,Malorni W
MA5-12739 was used in western blot to study the mechanism by which tissue transglutaminase overexpression sensitizes neuronal cell lines to apoptosis
Sat Jun 01 00:00:00 EDT 2002
Up-regulation of tissue-type transglutaminase after traumatic brain injury.
Journal of neurochemistry
Tolentino PJ,DeFord SM,Notterpek L,Glenn CC,Pike BR,Wang KK,Hayes RL
MA5-12739 was used in western blot to study the increased expression of tissue transglutaminase in a rat model of traumatic brain injury
Fri Feb 01 00:00:00 EST 2002
NMDA-evoked excitotoxicity increases tissue transglutaminase in cerebellar granule cells.
Neuroscience
Ientile R,Caccamo D,Macaione V,Torre V,Macaione S
MA5-12739 was used in western blot to study the involvement of tissue transglutaminase in NMDA-induced excitotoxicity in rat cerebellar granule cells
Mon Apr 07 00:00:00 EDT 2003
Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1.
Biochemical and biophysical research communications
Kang SK,Kim DK,Damron DS,Baek KJ,Im MJ
MA5-12739 was used in western blot to study the role of alpha(1B)-adrenoreceptor signaling molecules in calcium homeostasis
Fri Apr 26 00:00:00 EDT 2002
Tissue transglutaminase facilitates the polymerization of insulin-like growth factor-binding protein-1 (IGFBP-1) and leads to loss of IGFBP-1's ability to inhibit insulin-like growth factor-I-stimulated protein synthesis.
The Journal of biological chemistry
Sakai K,Busby WH,Clarke JB,Clemmons DR
MA5-12739 was used in western blot to study the involvement of tissue transglutaminase in the cellular function of insulin-like growth factor-binding protein-1
Fri Mar 23 00:00:00 EST 2001
Implication of tissue transglutaminase and desmoplakin in cell adhesion mechanism in human epidermis.
Molecular and cellular biochemistry
Esposito C,Lombardi ML,Ruocco V,Cozzolino A,Mariniello L,Porta R
MA5-12739 was used in immunohistochemistry to study the roles of tissue transglutaminase and desmoplakin in human epidermis cell adhesion
Wed Mar 01 00:00:00 EST 2000
