Proteintech

TH Polyclonal Antibody

TH Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

TH Antibody (25859-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed SH-SY5Y cells using 25859-1-AP (TH antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

TH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TH Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

Product Details

25859-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 56 publications 56 publications

Immunohistochemistry (IHC)

View 30 publications 30 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 32 publications 32 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Dog, Human, Mouse, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TH Fusion Protein Ag23075 (1-260 aa encoded by BC104967)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPTPDATTP QAKGFRRAVS ELDAKQAEAI MSPRFIGRRQ SLIEDARKER EAAVAAAAAA VPSEPGDPLE AVAFEEKEGK AMLNLLFSPR ATKPSALSRA VKVFETFEAK IHHLETRPAQ RPRAGGPHLE YFVRLEVRRG DLAALLSGVR QVSEDVRSPA GPKVPWFPRK VSELDKCHHL VTKFDPDLDL DHPGFSDQVY RQRRKLIAEI AFQYRHGDPI PRVEYTAEEI ATWKEVYTTL KGLYATHACG EHLEAFALLE R (1-260 aa encoded by BC104967)

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.

Journal of pharmaceutical analysis

Zhao Y,Wang Y,Wu Y,Tao C,Xu R,Chen Y,Qian L,Xu T,Lian X

Wed Feb 01 00:00:00 EST 2023

Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.

Bioengineering & translational medicine

Fan HX,Sheng S,Li DD,Li JJ,Wang GQ,Zhang F

Wed Mar 01 00:00:00 EST 2023

Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.

Bioengineering & translational medicine

Fan HX,Sheng S,Li DD,Li JJ,Wang GQ,Zhang F

Wed Mar 01 00:00:00 EST 2023

Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.

Bioengineering & translational medicine

Fan HX,Sheng S,Li DD,Li JJ,Wang GQ,Zhang F

Wed Mar 01 00:00:00 EST 2023

Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.

Bioengineering & translational medicine

Fan HX,Sheng S,Li DD,Li JJ,Wang GQ,Zhang F

Wed Mar 01 00:00:00 EST 2023

Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.

Bioengineering & translational medicine

Fan HX,Sheng S,Li DD,Li JJ,Wang GQ,Zhang F

Wed Mar 01 00:00:00 EST 2023

Heat-killed Lactobacillus murinus confers neuroprotection against dopamine neuronal loss by targeting NLRP3 inflammasome.

Bioengineering & translational medicine

Fan HX,Sheng S,Li DD,Li JJ,Wang GQ,Zhang F

Wed Mar 01 00:00:00 EST 2023

Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism.

Neuromolecular medicine

Qi Y,Zhang Z,Li Y,Zhao G,Huang J,Zhang Y,Xue J,Tang X

Fri Sep 01 00:00:00 EDT 2023

Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?

Journal of inflammation (London, England)

Cheng X,Lowin T,Honke N,Pongratz G

Tue Mar 14 00:00:00 EDT 2023

Components of the sympathetic nervous system as targets to modulate inflammation - rheumatoid arthritis synovial fibroblasts as neuron-like cells?

Journal of inflammation (London, England)

Cheng X,Lowin T,Honke N,Pongratz G

Tue Mar 14 00:00:00 EDT 2023

Biomimetic Biomembrane Encapsulation and Targeted Delivery of a Nitric Oxide Release Platform for Therapy of Parkinson's Disease.

ACS biomaterials science & engineering

Huang Z,Hu B,Xiang B,Fang H,Zhang B,Wang Y,Zhuo Y,Deng D,Wang X

Mon May 08 00:00:00 EDT 2023

Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.

Neural regeneration research

Yu HY,Sun T,Wang Z,Li H,Xu D,An J,Wen LL,Li JY,Li W,Feng J

Tue Aug 01 00:00:00 EDT 2023

Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson's disease.

Neural regeneration research

Yu HY,Sun T,Wang Z,Li H,Xu D,An J,Wen LL,Li JY,Li W,Feng J

Tue Aug 01 00:00:00 EDT 2023

Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.

Neural regeneration research

Kambey PA,Liu WY,Wu J,Bosco B,Nadeem I,Kanwore K,Gao DS

Fri Sep 01 00:00:00 EDT 2023

Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.

Neural regeneration research

Kambey PA,Liu WY,Wu J,Bosco B,Nadeem I,Kanwore K,Gao DS

Fri Sep 01 00:00:00 EDT 2023

α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation.

Neuromolecular medicine

Fan JK,Wang MC,Yang HM,Zhang JN,Gu L,Zhang H

Thu Jun 01 00:00:00 EDT 2023

Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.

CNS neuroscience & therapeutics

Kambey PA,Liu WY,Wu J,Tang C,Buberwa W,Saro A,Nyalali AMK,Gao D

Sun Oct 01 00:00:00 EDT 2023

Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model.

CNS neuroscience & therapeutics

Kambey PA,Liu WY,Wu J,Tang C,Buberwa W,Saro A,Nyalali AMK,Gao D

Sun Oct 01 00:00:00 EDT 2023

ONO-2506 Can Delay Levodopa-induced Dyskinesia in the Early Stage.

Neuroscience

Yuan Y,Zhang X,Wu Y,Lian P,Cao X,Xu Y

Sat Jul 15 00:00:00 EDT 2023

CXCR4 knockout induces neuropathological changes in the MPTP-lesioned model of Parkinson's disease.

Biochimica et biophysica acta. Molecular basis of disease

Ma J,Dong L,Chang Q,Chen S,Zheng J,Li D,Wu S,Yang H,Li X

Wed Feb 01 00:00:00 EST 2023

Ginsenoside Rg1 promotes astrocyte-to-neuron transdifferentiation in rat and its possible mechanism.

CNS neuroscience & therapeutics

Shen K,Wu D,Sun B,Zhu Y,Wang H,Zou W,Ma Y,Lu Z

Sun Jan 01 00:00:00 EST 2023

Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson's disease.

Neural regeneration research

Zhang HY,Jiang YC,Li JR,Yan JN,Wang XJ,Shen JB,Ke KF,Gu XS

Mon May 01 00:00:00 EDT 2023

α-Synuclein induces prodromal symptoms of Parkinson's disease via activating TLR2/MyD88/NF-κB pathway in Schwann cells of vagus nerve in a rat model.

Journal of neuroinflammation

Cheng Y,Tong Q,Yuan Y,Song X,Jiang W,Wang Y,Li W,Li Y,Zhang K

Tue Feb 14 00:00:00 EST 2023

Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease.

Nutrients

Guo TT,Zhang Z,Sun Y,Zhu RY,Wang FX,Ma LJ,Jiang L,Liu HD

Mon Feb 13 00:00:00 EST 2023

Imperatorin Improves Obesity-Induced Cardiac Sympathetic Nerve Injury Mediated by P2X4 Receptor in Stellate Sympathetic Ganglion.

International journal of molecular sciences

Zhang M,Wen Y,Liang P,Yang C,Tu H,Wei J,Du J,Zhan T,Liang S,Li G,Gao Y

Mon Jan 02 00:00:00 EST 2023

Upregulation of P2X7 Exacerbates Myocardial Ischemia-Reperfusion Injury through Enhancing Inflammation and Apoptosis in Diabetic Mice.

Journal of immunology (Baltimore, Md. : 1950)

Wu F,Wei H,Hu Y,Gao J,Xu S

Thu Jun 15 00:00:00 EDT 2023

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.

Open medicine (Warsaw, Poland)

Yang X,Liang X,Guo H,Ma L,Jian L,Zhao X,Wang J,Yang L,Meng Z,Jin Q

Sat Jul 16 00:00:00 EDT 2022

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.

Open medicine (Warsaw, Poland)

Yang X,Liang X,Guo H,Ma L,Jian L,Zhao X,Wang J,Yang L,Meng Z,Jin Q

Sat Jul 16 00:00:00 EDT 2022

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.

Open medicine (Warsaw, Poland)

Yang X,Liang X,Guo H,Ma L,Jian L,Zhao X,Wang J,Yang L,Meng Z,Jin Q

Sat Jul 16 00:00:00 EDT 2022

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.

Translational neuroscience

Huang L,Han Y,Zhou Q,Sun Z,Yan J

Sat Jan 01 00:00:00 EST 2022

Sleep Disturbance Alters Cocaine-Induced Locomotor Activity: Involvement of Striatal Neuroimmune and Dopamine Signaling.

Biomedicines

Roodsari SK,Cheng Y,Reed KM,Wellman LL,Sanford LD,Kim WK,Guo ML

Wed May 18 00:00:00 EDT 2022

Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.

Cell death discovery

Yan J,Sun W,Shen M,Zhang Y,Jiang M,Liu A,Ma H,Lai X,Wu J

Mon Jan 17 00:00:00 EST 2022

Idebenone improves motor dysfunction, learning and memory by regulating mitophagy in MPTP-treated mice.

Cell death discovery

Yan J,Sun W,Shen M,Zhang Y,Jiang M,Liu A,Ma H,Lai X,Wu J

Mon Jan 17 00:00:00 EST 2022

Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.

NPJ Parkinson's disease

Li J,Liu H,Wang X,Xia Y,Huang J,Wang T,Lin Z,Xiong N

Fri Jul 08 00:00:00 EDT 2022

Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.

Oxidative medicine and cellular longevity

Huang Z,Han J,Wu P,Wu C,Fan Y,Zhao L,Hao X,Chen D,Zhu M

Thu May 19 00:00:00 EDT 2022

Sorting Nexin 5 Plays an Important Role in Promoting Ferroptosis in Parkinson's Disease.

Oxidative medicine and cellular longevity

Huang Z,Han J,Wu P,Wu C,Fan Y,Zhao L,Hao X,Chen D,Zhu M

Thu May 19 00:00:00 EDT 2022

Integrated Metabolomics and Network Pharmacology to Reveal the Mechanisms of Guizhi-Fuling Treatment for Myocardial Ischemia.

Chemistry & biodiversity

Duan B,Ye Y,Zhou Z,Han L,Huang F,Li J,Wang Q,Zeng X,Yu X

Sat Oct 01 00:00:00 EDT 2022

Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.

Neural regeneration research

Yan JN,Zhang HY,Li JR,Chen Y,Jiang YC,Shen JB,Ke KF,Gu XS

Wed Jun 01 00:00:00 EDT 2022

Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease.

Neural regeneration research

Yan JN,Zhang HY,Li JR,Chen Y,Jiang YC,Shen JB,Ke KF,Gu XS

Wed Jun 01 00:00:00 EDT 2022

Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model.

Disease markers

Yang L,Wang X,Liu X,Chen X

Wed Sep 28 00:00:00 EDT 2022

NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.

Nature communications

Qi G,Zhang P,Li T,Li M,Zhang Q,He F,Zhang L,Cai H,Lv X,Qiao H,Chen X,Ming J,Tian B

Mon Jan 31 00:00:00 EST 2022

Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.

Journal of inflammation research

Zhong Y,Cai X,Ding L,Liao J,Liu X,Huang Y,Chen X,Long L

Sun May 01 00:00:00 EDT 2022

LPS activates neuroinflammatory pathways to induce depression in Parkinson's disease-like condition.

Frontiers in pharmacology

Zhang J,Xue B,Jing B,Tian H,Zhang N,Li M,Lu L,Chen L,Diao H,Chen Y,Wang M,Li X

Tue Oct 25 00:00:00 EDT 2022

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.

Journal of neuroinflammation

Kou L,Chi X,Sun Y,Han C,Wan F,Hu J,Yin S,Wu J,Li Y,Zhou Q,Zou W,Xiong N,Huang J,Xia Y,Wang T

Mon Jun 06 00:00:00 EDT 2022

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.

Journal of neuroinflammation

Kou L,Chi X,Sun Y,Han C,Wan F,Hu J,Yin S,Wu J,Li Y,Zhou Q,Zou W,Xiong N,Huang J,Xia Y,Wang T

Mon Jun 06 00:00:00 EDT 2022

Methamphetamine Disturbs Gut Homeostasis and Reshapes Serum Metabolome, Inducing Neurotoxicity and Abnormal Behaviors in Mice.

Frontiers in microbiology

Zhang KK,Chen LJ,Li JH,Liu JL,Wang LB,Xu LL,Yang JZ,Li XW,Xie XL,Wang Q

Sat May 07 00:00:00 EDT 2022

Expression profiles of microRNAs in midbrain of MPTP-treated mice determined by microRNA sequencing.

Neuroscience letters

Liu X,Qi Y,Zhao G,Zhang Z,Cao Y,Li Y,Xue J,Tang X

Sun Sep 25 00:00:00 EDT 2022

Systematic Input-Output Mapping Reveals Structural Plasticity of VTA Dopamine Neurons-Zona Incerta Loop Underlying the Social Buffering Effects in Learned Helplessness.

Molecular neurobiology

Cai H,Zhang P,Qi G,Zhang L,Li T,Li M,Lv X,Lei J,Ming J,Tian B

Tue Feb 01 00:00:00 EST 2022

A zona incerta-basomedial amygdala circuit modulates aversive expectation in emotional stress-induced aversive learning deficits.

Frontiers in cellular neuroscience

Zhang L,Zhang P,Qi G,Cai H,Li T,Li M,Cui C,Lei J,Ren K,Yang J,Ming J,Tian B

Tue Sep 13 00:00:00 EDT 2022

Chronic Cerebral Hypoperfusion Aggravates Parkinson's Disease Dementia-Like Symptoms and Pathology in 6-OHDA-Lesioned Rat through Interfering with Sphingolipid Metabolism.

Oxidative medicine and cellular longevity

Fan Y,Li M,Wu C,Wu Y,Han J,Wu P,Huang Z,Wang Q,Zhao L,Chen D,Zhu M

Fri Aug 19 00:00:00 EDT 2022

TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.

Life science alliance

Grelet S,Fréreux C,Obellianne C,Noguchi K,Howley BV,Dalton AC,Howe PH

Tue Feb 01 00:00:00 EST 2022

TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis.

Life science alliance

Grelet S,Fréreux C,Obellianne C,Noguchi K,Howley BV,Dalton AC,Howe PH

Tue Feb 01 00:00:00 EST 2022

Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices.

Biomolecules

Uçar B,Stefanova N,Humpel C

Wed Jan 19 00:00:00 EST 2022

Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway.

International immunopharmacology

Zhang J,Zhang N,Lei J,Jing B,Li M,Tian H,Xue B,Li X

Thu Dec 01 00:00:00 EST 2022

Fluoxetine shows neuroprotective effects against LPS-induced neuroinflammation via the Notch signaling pathway.

International immunopharmacology

Zhang J,Zhang N,Lei J,Jing B,Li M,Tian H,Xue B,Li X

Thu Dec 01 00:00:00 EST 2022

Exogenous Otx2 protects midbrain dopaminergic neurons from MPP⁺ by interacting with ATP5a1 and promoting ATP synthesis.

Neurotoxicology

Xue J,Li Y,Qi Y,Zhang Z,Tang X

Fri Jul 01 00:00:00 EDT 2022

Exogenous Otx2 protects midbrain dopaminergic neurons from MPP⁺ by interacting with ATP5a1 and promoting ATP synthesis.

Neurotoxicology

Xue J,Li Y,Qi Y,Zhang Z,Tang X

Fri Jul 01 00:00:00 EDT 2022

Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.

Journal of controlled release : official journal of the Controlled Release Society

Zhou X,Guo Q,Guo M,Li B,Peng W,Wang D,Ming D,Zheng B

Sun Oct 10 00:00:00 EDT 2021

Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.

Journal of controlled release : official journal of the Controlled Release Society

Zhou X,Guo Q,Guo M,Li B,Peng W,Wang D,Ming D,Zheng B

Sun Oct 10 00:00:00 EDT 2021

X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.

Journal of medicinal chemistry

Ning XL,Li YZ,Huo C,Deng J,Gao C,Zhu KR,Wang M,Wu YX,Yu JL,Ren YL,Luo ZY,Li G,Chen Y,Wang SY,Peng C,Yang LL,Wang ZY,Wu Y,Qian S,Li GB

Thu Jun 24 00:00:00 EDT 2021

Electroacupuncture Attenuates Neuropathic Pain and Comorbid Negative Behavior: The Involvement of the Dopamine System in the Amygdala.

Frontiers in neuroscience

Zhang XH,Feng CC,Pei LJ,Zhang YN,Chen L,Wei XQ,Zhou J,Yong Y,Wang K

Wed May 26 00:00:00 EDT 2021

Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry.

Frontiers in aging neuroscience

Zhang X,Chen W,Wu Y,Zeng W,Yuan Y,Cheng C,Yang X,Wang J,Yang X,Xu Y,Lei H,Cao X,Xu Y

Wed Nov 17 00:00:00 EST 2021

Exposure to Melamine cyanuric acid in adolescent mice caused emotional disorder and behavioral disorder.

Ecotoxicology and environmental safety

Wang S,Zhang J,Zhang S,Shi F,Feng D,Feng X

Mon Mar 15 00:00:00 EDT 2021

Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.

Oxidative medicine and cellular longevity

Zhou X,Lu J,Wei K,Wei J,Tian P,Yue M,Wang Y,Hong D,Li F,Wang B,Chen T,Fang X

Tue Mar 01 00:00:00 EST 2022

Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota.

Oxidative medicine and cellular longevity

Zhou X,Lu J,Wei K,Wei J,Tian P,Yue M,Wang Y,Hong D,Li F,Wang B,Chen T,Fang X

Tue Mar 01 00:00:00 EST 2022

Vagus Nerve Stimulation in Early Stage of Acute Myocardial Infarction Prevent Ventricular Arrhythmias and Cardiac Remodeling.

Frontiers in cardiovascular medicine

Zhao S,Dai Y,Ning X,Tang M,Zhao Y,Li Z,Zhang S

Fri May 14 00:00:00 EDT 2021

Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance.

Nature communications

Chen YT,Yang QY,Hu Y,Liu XD,de Avila JM,Zhu MJ,Nathanielsz PW,Du M

Thu Nov 25 00:00:00 EST 2021

Calcitriol Alleviates MPP⁺- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.

Frontiers in aging neuroscience

Hu J,Wu J,Wan F,Kou L,Yin S,Sun Y,Li Y,Zhou Q,Wang T

Tue Aug 17 00:00:00 EDT 2021

Calcitriol Alleviates MPP⁺- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.

Frontiers in aging neuroscience

Hu J,Wu J,Wan F,Kou L,Yin S,Sun Y,Li Y,Zhou Q,Wang T

Tue Aug 17 00:00:00 EDT 2021

Calcitriol Alleviates MPP⁺- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.

Frontiers in aging neuroscience

Hu J,Wu J,Wan F,Kou L,Yin S,Sun Y,Li Y,Zhou Q,Wang T

Tue Aug 17 00:00:00 EDT 2021

Calcitriol Alleviates MPP⁺- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease.

Frontiers in aging neuroscience

Hu J,Wu J,Wan F,Kou L,Yin S,Sun Y,Li Y,Zhou Q,Wang T

Tue Aug 17 00:00:00 EDT 2021

Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson's Disease.

Frontiers in neuroscience

Huang W,Lv Q,Xiao Y,Zhong Z,Hu B,Yan S,Yan Y,Zhang J,Shi T,Jiang L,Li W,Lu G

Tue Dec 07 00:00:00 EST 2021

NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.

Molecular medicine reports

Gao H,Wang D,Jiang S,Mao J,Yang X

Tue Jun 01 00:00:00 EDT 2021

NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.

Molecular medicine reports

Gao H,Wang D,Jiang S,Mao J,Yang X

Tue Jun 01 00:00:00 EDT 2021

Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.

Molecules (Basel, Switzerland)

Chen J,Chen Y,Zheng Y,Zhao J,Yu H,Zhu J,Li D

Mon Sep 13 00:00:00 EDT 2021

Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats.

Frontiers in immunology

Zheng CQ,Fan HX,Li XX,Li JJ,Sheng S,Zhang F

Mon Nov 01 00:00:00 EDT 2021

Electroacupuncture improves cardiac function and reduces infarct size by modulating cardiac autonomic remodeling in a mouse model of myocardial ischemia.

Acupuncture in medicine : journal of the British Medical Acupuncture Society

Lu SF,Wang JM,Yuan J,Yang WX,Chen LY,Zhang T,Jing XY,Zhuang Y,Zhang CS,Fu SP,Yu ML

Wed Dec 01 00:00:00 EST 2021

Electroacupuncture improves cardiac function and reduces infarct size by modulating cardiac autonomic remodeling in a mouse model of myocardial ischemia.

Acupuncture in medicine : journal of the British Medical Acupuncture Society

Lu SF,Wang JM,Yuan J,Yang WX,Chen LY,Zhang T,Jing XY,Zhuang Y,Zhang CS,Fu SP,Yu ML

Wed Dec 01 00:00:00 EST 2021

Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis.

Redox biology

Li Z,Li Q,Wang L,Li C,Xu M,Duan Y,Ma L,Li T,Chen Q,Wang Y,Wang Y,Feng J,Yin X,Wang X,Han J,Lu C

Mon Nov 01 00:00:00 EDT 2021

Dendrobium nobile Lindl alkaloid attenuates 6-OHDA-induced dopamine neurotoxicity.

Biotechnology and applied biochemistry

Li DD,Wang GQ,Wu Q,Shi JS,Zhang F

Wed Dec 01 00:00:00 EST 2021

Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function.

Journal of cellular and molecular medicine

Teng Y,Liu Z,Chen X,Liu Y,Geng F,Le W,Jiang H,Yang L

Wed Sep 01 00:00:00 EDT 2021

Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function.

Journal of cellular and molecular medicine

Teng Y,Liu Z,Chen X,Liu Y,Geng F,Le W,Jiang H,Yang L

Wed Sep 01 00:00:00 EDT 2021

Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2.

Brain : a journal of neurology

Xia Y,Zhang G,Kou L,Yin S,Han C,Hu J,Wan F,Sun Y,Wu J,Li Y,Huang J,Xiong N,Zhang Z,Wang T

Tue Aug 17 00:00:00 EDT 2021

Primary Cilia in Amacrine Cells in Retinal Development.

Investigative ophthalmology & visual science

Ning K,Sendayen BE,Kowal TJ,Wang B,Jones BW,Hu Y,Sun Y

Thu Jul 01 00:00:00 EDT 2021

Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Chen LJ,Zhi X,Zhang KK,Wang LB,Li JH,Liu JL,Xu LL,Yoshida JS,Xie XL,Wang Q

Mon Feb 01 00:00:00 EST 2021

Nilotinib inhibits microglia-mediated neuroinflammation to protect against dopaminergic neuronal death in Parkinson's disease models.

International immunopharmacology

Wu J,Xu X,Zheng L,Mo J,Jin X,Bao Y

Fri Oct 01 00:00:00 EDT 2021

Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion.

Molecular neurobiology

He F,Zhang P,Zhang Q,Qi G,Cai H,Li T,Li M,Lu J,Lin J,Ming J,Tian B

Mon Nov 01 00:00:00 EDT 2021

Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.

CNS neuroscience & therapeutics

Chen H,Teng Y,Chen X,Liu Z,Geng F,Liu Y,Jiang H,Wang Z,Yang L

Mon Nov 01 00:00:00 EDT 2021

Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.

CNS neuroscience & therapeutics

Chen H,Teng Y,Chen X,Liu Z,Geng F,Liu Y,Jiang H,Wang Z,Yang L

Mon Nov 01 00:00:00 EDT 2021

Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.

CNS neuroscience & therapeutics

Chen H,Teng Y,Chen X,Liu Z,Geng F,Liu Y,Jiang H,Wang Z,Yang L

Mon Nov 01 00:00:00 EDT 2021

Platelet-derived growth factor (PDGF)-BB protects dopaminergic neurons via activation of Akt/ERK/CREB pathways to upregulate tyrosine hydroxylase.

CNS neuroscience & therapeutics

Chen H,Teng Y,Chen X,Liu Z,Geng F,Liu Y,Jiang H,Wang Z,Yang L

Mon Nov 01 00:00:00 EDT 2021

Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.

Biochemistry and biophysics reports

Sun X,Kato H,Sato H,Torio M,Han X,Zhang Y,Hirofuji Y,Kato TA,Sakai Y,Ohga S,Fukumoto S,Masuda K

Thu Jul 01 00:00:00 EDT 2021

Biomaterial based strategies to reconstruct the nigrostriatal pathway in organotypic slice co-cultures.

Acta biomaterialia

Ucar B,Kajtez J,Foidl BM,Eigel D,Werner C,Long KR,Emnéus J,Bizeau J,Lomora M,Pandit A,Newland B,Humpel C

Mon Feb 01 00:00:00 EST 2021

MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.

Aging and disease

Xue C,Li X,Ba L,Zhang M,Yang Y,Gao Y,Sun Z,Han Q,Zhao RC

Sun Aug 01 00:00:00 EDT 2021

LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP.

Frontiers in pharmacology

Tan Y,Xu Y,Cheng C,Zheng C,Zeng W,Wang J,Zhang X,Yang X,Wang J,Yang X,Nie S,Cao X

Mon Sep 28 00:00:00 EDT 2020

Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.

ACS chemical neuroscience

Lv R,Du L,Zhou F,Yuan X,Liu X,Zhang L

Wed Oct 21 00:00:00 EDT 2020

Differences in the number of oxytocin, vasopressin, and tyrosine hydroxylase cells in brain regions associated with mating among great, midday, and Mongolian gerbils.

Brain research

Yu P,Zhang M,Nan X,Zhao H,Gong D

Wed Apr 15 00:00:00 EDT 2020

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson's Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis.

ACS chemical neuroscience

Zhu Y,Huan F,Wang J,Xie X,Yu G,Wang X,Jiang L,Gao R,Xiao H,Ding H,Wang J

Wed Oct 21 00:00:00 EDT 2020

Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish.

Frontiers in neuroscience

Joseph TP,Jagadeesan N,Sai LY,Lin SL,Sahu S,Schachner M

Mon Sep 28 00:00:00 EDT 2020

Fenvalerate triggers Parkinson-like symptom during zebrafish development through initiation of autophagy and p38 MAPK/mTOR signaling pathway.

Chemosphere

Zhu J,Xia R,Liu Z,Shen J,Gong X,Hu Y,Chen H,Yu Y,Gao W,Wang C,Wang SL

Sun Mar 01 00:00:00 EST 2020

Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.

AMB Express

Fang X,Zhou X,Miao Y,Han Y,Wei J,Chen T

Fri Apr 24 00:00:00 EDT 2020

Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model.

Brain research bulletin

Gao MR,Wang M,Jia YY,Tian DD,Liu A,Wang WJ,Yang L,Chen JY,Yang Q,Liu R,Wu YM

Sun Nov 01 00:00:00 EDT 2020

Quantitative Phosphoproteomic Analysis in Alpha-Synuclein Transgenic Mice Reveals the Involvement of Aberrant p25/Cdk5 Signaling in Early-stage Parkinson's Disease.

Cellular and molecular neurobiology

He F,Qi G,Zhang Q,Cai H,Li T,Li M,Zhang Q,Chen J,Ming J,Tian B,Zhang P

Sat Aug 01 00:00:00 EDT 2020

The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts.

International journal of cardiology

Deng J,Zhou X,Wang M,Wang M,Zhou L,Meng G,Wang Y,Wang Z,Zhang Y,Zhou Z,Yu L,Jiang H

Fri Mar 15 00:00:00 EDT 2019

The effects of interleukin 17A on left stellate ganglion remodeling are mediated by neuroimmune communication in normal structural hearts.

International journal of cardiology

Deng J,Zhou X,Wang M,Wang M,Zhou L,Meng G,Wang Y,Wang Z,Zhang Y,Zhou Z,Yu L,Jiang H

Fri Mar 15 00:00:00 EDT 2019

Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1.

Journal of neurochemistry

Fang X,Tian P,Zhao X,Jiang C,Chen T

Thu Aug 01 00:00:00 EDT 2019

Neuroprotective effects of an engineered commensal bacterium in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Parkinson disease mouse model via producing glucagon-like peptide-1.

Journal of neurochemistry

Fang X,Tian P,Zhao X,Jiang C,Chen T

Thu Aug 01 00:00:00 EDT 2019

Microglia as modulators of exosomal alpha-synuclein transmission.

Cell death & disease

Xia Y,Zhang G,Han C,Ma K,Guo X,Wan F,Kou L,Yin S,Liu L,Huang J,Xiong N,Wang T

Wed Feb 20 00:00:00 EST 2019

Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.

Frontiers in behavioral neuroscience

Lin L,Yu L,Xiang H,Hu X,Yuan X,Zhu H,Li H,Zhang H,Hou T,Cao J,Wu S,Su W,Li M

Thu Oct 01 00:00:00 EDT 2020

Effects of Acupuncture on Behavioral Stereotypies and Brain Dopamine System in Mice as a Model of Tourette Syndrome.

Frontiers in behavioral neuroscience

Lin L,Yu L,Xiang H,Hu X,Yuan X,Zhu H,Li H,Zhang H,Hou T,Cao J,Wu S,Su W,Li M

Thu Oct 01 00:00:00 EDT 2020

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP⁺ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway.

Frontiers in neurology

Guo X,Han C,Ma K,Xia Y,Wan F,Yin S,Kou L,Sun Y,Wu J,Hu J,Huang J,Xiong N,Wang T

Wed Sep 30 00:00:00 EDT 2020

Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder.

Biochemical and biophysical research communications

Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

Tue Jun 11 00:00:00 EDT 2019

Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia.

Nature communications

Zhang Q,Hu DX,He F,Li CY,Qi GJ,Cai HW,Li TX,Ming J,Zhang P,Chen XQ,Tian B

Wed Jul 03 00:00:00 EDT 2019

Repetitive transcranial magnetic stimulation protects mice against 6-OHDA-induced Parkinson's disease symptoms by regulating brain amyloid β_1-42 level.

Molecular and cellular biochemistry

Ba F,Zhou Y,Zhou J,Chen X

Thu Aug 01 00:00:00 EDT 2019

Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.

Diabetes

Zhao H,Shang Q,Pan Z,Bai Y,Li Z,Zhang H,Zhang Q,Guo C,Zhang L,Wang Q

Thu Feb 01 00:00:00 EST 2018

Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.

Diabetes

Zhao H,Shang Q,Pan Z,Bai Y,Li Z,Zhang H,Zhang Q,Guo C,Zhang L,Wang Q

Thu Feb 01 00:00:00 EST 2018

Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo.

Molecular medicine reports

Chen H,Xu J,Lv Y,He P,Liu C,Jiao J,Li S,Mao X,Xue X

Sat Dec 01 00:00:00 EST 2018

Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP‑induced Parkinson's disease models in vitro and in vivo.

Molecular medicine reports

Chen H,Xu J,Lv Y,He P,Liu C,Jiao J,Li S,Mao X,Xue X

Sat Dec 01 00:00:00 EST 2018

TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.

Frontiers in cellular neuroscience

Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

Tue Apr 13 00:00:00 EDT 2021

TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone.

Frontiers in cellular neuroscience

Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

Tue Apr 13 00:00:00 EDT 2021

TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.

Frontiers in cellular neuroscience

Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

Tue Sep 29 00:00:00 EDT 2020

TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.

Frontiers in cellular neuroscience

Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

Tue Sep 29 00:00:00 EDT 2020

TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.

Frontiers in cellular neuroscience

Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

Tue Sep 29 00:00:00 EDT 2020

TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.

Frontiers in cellular neuroscience

Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

Tue Sep 29 00:00:00 EDT 2020

TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect.

Frontiers in cellular neuroscience

Zheng C,Chen G,Tan Y,Zeng W,Peng Q,Wang J,Cheng C,Yang X,Nie S,Xu Y,Zhang Z,Papa SM,Ye K,Cao X

Tue Sep 29 00:00:00 EDT 2020

Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.

Neural regeneration research

Wang SJ,Wang Q,Ma J,Yu PH,Wang ZM,Wang B

Mon Jan 01 00:00:00 EST 2018

Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder.

Biochemistry and biophysics reports

Nguyen HTN,Kato H,Masuda K,Yamaza H,Hirofuji Y,Sato H,Pham TTM,Takayama F,Sakai Y,Ohga S,Taguchi T,Nonaka K

Sat Dec 01 00:00:00 EST 2018

Biochemistry and biophysics reports

Nguyen HTN,Kato H,Masuda K,Yamaza H,Hirofuji Y,Sato H,Pham TTM,Takayama F,Sakai Y,Ohga S,Taguchi T,Nonaka K

Sat Dec 01 00:00:00 EST 2018

Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.

Chemosphere

Hu Q,Guo F,Zhao F,Fu Z

Sat Apr 01 00:00:00 EDT 2017

Effects of titanium dioxide nanoparticles exposure on parkinsonism in zebrafish larvae and PC12.

Chemosphere

Hu Q,Guo F,Zhao F,Fu Z

Sat Apr 01 00:00:00 EDT 2017

Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.

Journal of the neurological sciences

Liu J,Wang F,Liu S,Du J,Hu X,Xiong J,Fang R,Chen W,Sun J

Sun Oct 15 00:00:00 EDT 2017

Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.

Journal of the neurological sciences

Liu J,Wang F,Liu S,Du J,Hu X,Xiong J,Fang R,Chen W,Sun J

Sun Oct 15 00:00:00 EDT 2017

Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.

Journal of the neurological sciences

Liu J,Wang F,Liu S,Du J,Hu X,Xiong J,Fang R,Chen W,Sun J

Sun Oct 15 00:00:00 EDT 2017

Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1.

Journal of the neurological sciences

Liu J,Wang F,Liu S,Du J,Hu X,Xiong J,Fang R,Chen W,Sun J

Sun Oct 15 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: dystonia 14; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase

View more View less

Gene Aliases: DYT14; DYT5b; TH; The; TYH

View more View less

UniProt ID: (Human) P07101, (Mouse) P24529, (Rat) P04177

View more View less

Entrez Gene ID: (Human) 7054, (Mouse) 21823, (Rat) 25085

View more View less

Function(s)

tyrosine 3-monooxygenase activity protein binding ferrous iron binding ferric iron binding amino acid binding oxygen binding enzyme binding protein domain specific binding tetrahydrobiopterin binding dopamine binding monooxygenase activity iron ion binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen metal ion binding

Process(es)

response to hypoxia synaptic transmission, dopaminergic dopamine biosynthetic process from tyrosine heart development visual perception learning memory mating behavior locomotory behavior regulation of heart contraction aromatic amino acid family metabolic process organ morphogenesis aminergic neurotransmitter loading into synaptic vesicle neurotransmitter biosynthetic process dopamine biosynthetic process epinephrine biosynthetic process norepinephrine biosynthetic process catecholamine biosynthetic process eye photoreceptor cell development eating behavior response to ethanol embryonic camera-type eye morphogenesis oxidation-reduction process response to amphetamine heart morphogenesis fatty acid metabolic process sphingolipid metabolic process sensory perception of sound response to water deprivation response to light stimulus response to herbicide response to salt stress anatomical structure morphogenesis response to zinc ion multicellular organism aging response to activity glycoside metabolic process phthalate metabolic process cerebral cortex development response to nutrient levels response to estradiol response to lipopolysaccharide isoquinoline alkaloid metabolic process social behavior cellular response to drug response to isolation stress response to immobilization stress terpene metabolic process circadian sleep/wake cycle response to peptide hormone pigmentation response to ether response to pyrethroid response to corticosterone response to electrical stimulus phytoalexin metabolic process cellular response to manganese ion cellular response to nicotine cellular response to glucose stimulus cellular response to growth factor stimulus response to metal ion response to organic cyclic compound response to insecticide response to nicotine response to drug response to steroid hormone cognition protein homotetramerization response to growth factor cellular response to alkaloid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

TH Polyclonal Antibody

TH Antibody (25859-1-AP) in ICC/IF

Product Details

25859-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!