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TIM-1 Antibody (MA5-23634) in Flow
Flow cytometry of TIM-1 in (A) Unstimulated and (B) Th2-stimulated human peripheral blood mononuclear cells (PBMCs). Samples were incubated in TIM-1 monoclonal antibody (Product # MA5-23634) followed by Mouse Anti-Human CD4 APC-conjugated Monoclonal Antibody. Quadrant markers were set based on control antibody staining.
Product Details
MA5-23634
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2B
Class
Monoclonal
Type
Antibody
Clone
219211
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TIM-1/KIM-1/HAVCR Ser21-Thr288
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
Buffered saline solution with BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606143
Product Specific Information
This antibody does not cross-react with recombinant mouse (rm) TIM-1, rmTIM-2, or rhTIM-3.
Target Information
CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD365; HAVcr-1; Hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIMD-1
Gene Aliases: CD365; HAVCR; HAVCR-1; HAVCR1; KIM-1; KIM1; TIM; TIM-1; TIM1; TIMD-1; TIMD1
UniProt ID: (Human) Q96D42
Entrez Gene ID: (Human) 26762
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