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Product Details
MA5-30628
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
024
Immunogen
Recombinant Human TIMD3 protein (Met1-Arg200)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786330
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human TIMD3/HAVCR2.
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD366; FLJ14428; HAVcr-2; Hepatitis A virus cellular receptor 2; kidney injury molecule-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM-3; TIMD-3
Gene Aliases: CD366; HAVcr-2; HAVCR2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3
UniProt ID: (Human) Q8TDQ0
Entrez Gene ID: (Human) 84868
adaptive immune response
macrophage activation involved in immune response
natural killer cell tolerance induction
regulation of tolerance induction dependent upon immune response
negative regulation of T-helper 1 type immune response
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
inflammatory response
negative regulation of gene expression
negative regulation of myeloid dendritic cell activation
negative regulation of NF-kappaB transcription factor activity
negative regulation of interferon-alpha production
negative regulation of interferon-gamma production
negative regulation of interleukin-2 production
negative regulation of interleukin-3 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 production
positive regulation of interleukin-4 production
negative regulation of natural killer cell activation
toll-like receptor 3 signaling pathway
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of macrophage activation
innate immune response
defense response to Gram-positive bacterium
maternal process involved in female pregnancy
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
negative regulation of granulocyte colony-stimulating factor production
negative regulation of defense response to bacterium
positive regulation of defense response to bacterium
positive regulation of NIK/NF-kappaB signaling
positive regulation of tumor necrosis factor secretion
negative regulation of immunological synapse formation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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