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Product Details
PA5-17134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues at the amino terminus of human TLR1 protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10982826
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD281; TIL; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein
Gene Aliases: CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1
UniProt ID: (Human) Q15399
Entrez Gene ID: (Human) 7096
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
toll-like receptor 1 signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
macrophage activation
detection of triacyl bacterial lipopeptide
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
innate immune response
positive regulation of interleukin-6 biosynthetic process
regulation of cytokine secretion
cellular response to triacyl bacterial lipopeptide
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