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Product Details
A15378
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2B4A1
Immunogen
human Toll-like Receptor 2 (TLR2) from Recombinant TLR2
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.5
Contains
<0.1% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2534392
Target Information
TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD282; TLR-2; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4
Gene Aliases: CD282; TIL4; TLR2
UniProt ID: (Human) O60603
Entrez Gene ID: (Human) 7097
lipopolysaccharide binding
lipopolysaccharide receptor activity
receptor activity
transmembrane signaling receptor activity
protein binding
signaling pattern recognition receptor activity
Toll-like receptor binding
triacyl lipopeptide binding
peptidoglycan binding
protein heterodimerization activity
cytokine secretion involved in immune response
MyD88-dependent toll-like receptor signaling pathway
apoptotic process
inflammatory response
immune response
signal transduction
I-kappaB phosphorylation
positive regulation of gene expression
positive regulation of Wnt signaling pathway
lipopolysaccharide-mediated signaling pathway
interleukin-10 production
positive regulation of chemokine production
positive regulation of interferon-beta production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
positive regulation of NF-kappaB import into nucleus
detection of triacyl bacterial lipopeptide
detection of diacyl bacterial lipopeptide
innate immune response
positive regulation of transcription from RNA polymerase II promoter
regulation of cytokine secretion
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
cellular response to bacterial lipopeptide
cellular response to lipoteichoic acid
cellular response to diacyl bacterial lipopeptide
cellular response to triacyl bacterial lipopeptide
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