Product References
TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.
Frontiers in immunology
Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S
48-2300 was used in Western Blotting to report TLR4 as one of the novel receptors to facilitate the attachment and entry of CHIKV in host macrophages, the TLR4-CHIKV-E2 interactions are essential for efficient viral entry and modulation of infection-induced pro-inflammatory responses in host macrophages, which might have translational implication for designing future therapeutics to regulate the CHIKV infection.
Thu May 18 00:00:00 EDT 2023
TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.
Frontiers in immunology
Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S
48-2300 was used in Western Blotting to report TLR4 as one of the novel receptors to facilitate the attachment and entry of CHIKV in host macrophages, the TLR4-CHIKV-E2 interactions are essential for efficient viral entry and modulation of infection-induced pro-inflammatory responses in host macrophages, which might have translational implication for designing future therapeutics to regulate the CHIKV infection.
Thu May 18 00:00:00 EDT 2023
TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.
Frontiers in immunology
Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S
48-2300 was used in Western Blotting to report TLR4 as one of the novel receptors to facilitate the attachment and entry of CHIKV in host macrophages, the TLR4-CHIKV-E2 interactions are essential for efficient viral entry and modulation of infection-induced pro-inflammatory responses in host macrophages, which might have translational implication for designing future therapeutics to regulate the CHIKV infection.
Thu May 18 00:00:00 EDT 2023
Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolism.
Frontiers in nutrition
Pirozzi C,Coretti L,Opallo N,Bove M,Annunziata C,Comella F,Turco L,Lama A,Trabace L,Meli R,Lembo F,Mattace Raso G
48-2300 was used in Western Blotting to study the effects of palmitoylethanolamide (PEA) on intestinal inflammation and microbiota alterations resulting from lipid overnutrition.
Wed Aug 23 00:00:00 EDT 2023
Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolism.
Frontiers in nutrition
Pirozzi C,Coretti L,Opallo N,Bove M,Annunziata C,Comella F,Turco L,Lama A,Trabace L,Meli R,Lembo F,Mattace Raso G
48-2300 was used in Western Blotting to study the effects of palmitoylethanolamide (PEA) on intestinal inflammation and microbiota alterations resulting from lipid overnutrition.
Wed Aug 23 00:00:00 EDT 2023
Fatty Acid-Binding Protein 4 is Essential for the Inflammatory and Metabolic Response of Microglia to Lipopolysaccharide.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Kagawa Y,Low YL,Pyun J,Doglione U,Short JL,Pan Y,Nicolazzo JA
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Fri Sep 01 00:00:00 EDT 2023
Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells.
Oxidative medicine and cellular longevity
de Sousa JAC,Azul FVCS,de Araújo AB,Tomé RC,Silva FRM,de Vasconcelos SMM,Rios FJ,Leal LKAM
48-2300 was used in Western Blotting to demonstrate the potent anti-inflammatory properties of EPI in microglial cells.
Tue May 09 00:00:00 EDT 2023
Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model.
International journal of molecular sciences
Vargas-Pozada EE,Ramos-Tovar E,Rodriguez-Callejas JD,Cardoso-Lezama I,Galindo-Gómez S,Talamás-Lara D,Vásquez-Garzón VR,Arellanes-Robledo J,Tsutsumi V,Villa-Treviño S,Muriel P
48-2300 was used in Western Blotting to evaluate the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH.
Thu Sep 01 00:00:00 EDT 2022
Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model.
International journal of molecular sciences
Vargas-Pozada EE,Ramos-Tovar E,Rodriguez-Callejas JD,Cardoso-Lezama I,Galindo-Gómez S,Talamás-Lara D,Vásquez-Garzón VR,Arellanes-Robledo J,Tsutsumi V,Villa-Treviño S,Muriel P
48-2300 was used in Western Blotting to evaluate the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH.
Thu Sep 01 00:00:00 EDT 2022
Ameliorative Effect of D-Carvone against Hepatic Ischemia-Reperfusion-Induced Injury in Rats.
Life (Basel, Switzerland)
Mohamed ME,Younis NS
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunohistochemistry
Tue Sep 27 00:00:00 EDT 2022
Ameliorative Effect of D-Carvone against Hepatic Ischemia-Reperfusion-Induced Injury in Rats.
Life (Basel, Switzerland)
Mohamed ME,Younis NS
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunohistochemistry
Tue Sep 27 00:00:00 EDT 2022
Ishige okamurae Attenuates Neuroinflammation and Cognitive Deficits in Mice Intracerebroventricularly Injected with LPS via Regulating TLR-4/MyD88-Dependent Pathways.
Antioxidants (Basel, Switzerland)
Kwon OY,Lee SH
48-2300 was used in Western Blotting to demonstrate anti-neuroinflammatory activity of Ishige okamuae (IOE) by regulation of TLR-4/MyD88-dependent signaling pathways.
Thu Dec 29 00:00:00 EST 2022
Ishige okamurae Attenuates Neuroinflammation and Cognitive Deficits in Mice Intracerebroventricularly Injected with LPS via Regulating TLR-4/MyD88-Dependent Pathways.
Antioxidants (Basel, Switzerland)
Kwon OY,Lee SH
48-2300 was used in Western Blotting to demonstrate anti-neuroinflammatory activity of Ishige okamuae (IOE) by regulation of TLR-4/MyD88-dependent signaling pathways.
Thu Dec 29 00:00:00 EST 2022
Exosomal RNF157 mRNA from prostate cancer cells contributes to M2 macrophage polarization through destabilizing HDAC1.
Frontiers in oncology
Guan H,Mao L,Wang J,Wang S,Yang S,Wu H,Sun W,Chen Z,Chen M
48-2300 was used in Western Blot to investigate the role of exosomal RNF157 mRNA in prostate cancer development.
Fri Oct 21 00:00:00 EDT 2022
Sex differences in TLR4 expression in SHR do not contribute to sex differences in blood pressure or the renal T cell profile.
American journal of physiology. Regulatory, integrative and comparative physiology
Belanger KM,Mohamed R,Webb RC,Sullivan JC
48-2300 was used in Western Blotting to indicate that although male spontaneously hypertensive rats (SHR) have greater renal TLR4 expression than females, TLR4 does not contribute to the higher blood pressure and more proinflammatory renal T cell profile in males versus females.
Fri Apr 01 00:00:00 EDT 2022
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.
Science translational medicine
Yu J,Zhu C,Wang X,Kim K,Bartolome A,Dongiovanni P,Yates KP,Valenti L,Carrer M,Sadowski T,Qiang L,Tabas I,Lavine JE,Pajvani UB
48-2300 was used in Immunohistochemistry to identify if increased expression of the Notch ligand Jagged1 (JAG1) tracked with Notch activation and nonalcoholic fatty liver disease (NAFLD) activity score (NAS) in human liver biopsy specimens and mouse NASH models.
Wed Jun 23 00:00:00 EDT 2021
Fetuin-A secretion from β-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion.
Journal of cell science
Mukhuty A,Fouzder C,Kundu R
48-2300 was used in Flow cytometry/Cell sorting to support an association of fetuin-A with islet inflammation and β-cell dysfunction, owing to its role as a key chemoattractant and macrophage polarizing factor.
Mon Nov 01 00:00:00 EDT 2021
Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats.
Clinical and experimental pharmacology & physiology
Badawi GA,Shokr MM,Zaki HF,Mohamed AF
48-2300 was used in Western Blotting to find that PTX or its combination with phenytoin represent a promising drug to inhibit the epilepsy progression via targeting the HMGB1/TLR4/RAGE signalling pathway.
Sun Aug 01 00:00:00 EDT 2021
Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats.
Clinical and experimental pharmacology & physiology
Badawi GA,Shokr MM,Zaki HF,Mohamed AF
48-2300 was used in Western Blotting to find that PTX or its combination with phenytoin represent a promising drug to inhibit the epilepsy progression via targeting the HMGB1/TLR4/RAGE signalling pathway.
Sun Aug 01 00:00:00 EDT 2021
Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways.
Evidence-based complementary and alternative medicine : eCAM
Liu L,Zhou Y,Dai D,Xia H,Zhao K,Zhang J
48-2300 was used in Western Blotting to investigate the effect of Kangxian ruangan on nonalcoholic fatty liver disease fibrosis in vivo and in vitro.
Tue Aug 24 00:00:00 EDT 2021
Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways.
Evidence-based complementary and alternative medicine : eCAM
Liu L,Zhou Y,Dai D,Xia H,Zhao K,Zhang J
48-2300 was used in Western Blotting to investigate the effect of Kangxian ruangan on nonalcoholic fatty liver disease fibrosis in vivo and in vitro.
Tue Aug 24 00:00:00 EDT 2021
hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis.
Scientific reports
Lagosz-Cwik KB,Wielento A,Lipska W,Kantorowicz M,Darczuk D,Kaczmarzyk T,Gibbs S,Potempa J,Grabiec AM
48-2300 was used in Western Blot to determine the usefulness of the recently released hTERT-immortalized GF (TIGF) cell line for studies of host-pathogen interactions.
Mon May 24 00:00:00 EDT 2021
hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis.
Scientific reports
Lagosz-Cwik KB,Wielento A,Lipska W,Kantorowicz M,Darczuk D,Kaczmarzyk T,Gibbs S,Potempa J,Grabiec AM
48-2300 was used in Western Blot to determine the usefulness of the recently released hTERT-immortalized GF (TIGF) cell line for studies of host-pathogen interactions.
Mon May 24 00:00:00 EDT 2021
The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties.
Journal of neuroinflammation
Buzhdygan TP,Rodrigues CR,McGary HM,Khan JA,Andrews AM,Rawls SM,Ramirez SH
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Mon Mar 01 00:00:00 EST 2021
The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties.
Journal of neuroinflammation
Buzhdygan TP,Rodrigues CR,McGary HM,Khan JA,Andrews AM,Rawls SM,Ramirez SH
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Mon Mar 01 00:00:00 EST 2021
Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.
Journal of neuroinflammation
Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Fri Mar 05 00:00:00 EST 2021
Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.
Journal of neuroinflammation
Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Fri Mar 05 00:00:00 EST 2021
Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.
Journal of neuroinflammation
Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Fri Mar 05 00:00:00 EST 2021
Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.
Journal of neuroinflammation
Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Fri Mar 05 00:00:00 EST 2021
Distinct effects of calcineurin dependent and independent immunosuppressants on endotoxaemia-induced nephrotoxicity in rats: Role of androgens.
Clinical and experimental pharmacology & physiology
Elzokm SS,Fouda MA,Abdel Moneim RA,El-Mas MM
48-2300 was used in Western Blotting to reveal opposite effects for calcineurin-dependent (exaggeration) and -independent immunosuppressants (amelioration) on renal defects of endotoxaemia and implicate androgenic pathways in the worsened endotoxic renal profile induced by CNIs.
Wed Sep 01 00:00:00 EDT 2021
Solute carrier family 12 member 8 impacts the biological behaviors of breast carcinoma cells by activating TLR/NLR signaling pathway.
Cytotechnology
Li L,Xia J,Cui R,Kong B
48-2300 was used in Western Blotting to suggest that SLC12A8 plays a promoting effect on the cells viability, invasiveness and motility in breast carcinoma by activating TLR/NLR signaling pathway.
Mon Feb 01 00:00:00 EST 2021
Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling.
The Journal of experimental medicine
Lim TJF,Bunjamin M,Ruedl C,Su IH
48-2300 was used in Western Blotting to investigate the role and mechanism of Talin in regulating skin dendritic cells (DCs) during inflammatory responses.
Mon Aug 03 00:00:00 EDT 2020
TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.
eLife
Hussain S,Johnson CG,Sciurba J,Meng X,Stober VP,Liu C,Cyphert-Daly JM,Bulek K,Qian W,Solis A,Sakamachi Y,Trempus CS,Aloor JJ,Gowdy KM,Foster WM,Hollingsworth JW,Tighe RM,Li X,Fessler MB,Garantziotis S
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunoprecipitation
Tue Jan 28 00:00:00 EST 2020
TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.
eLife
Hussain S,Johnson CG,Sciurba J,Meng X,Stober VP,Liu C,Cyphert-Daly JM,Bulek K,Qian W,Solis A,Sakamachi Y,Trempus CS,Aloor JJ,Gowdy KM,Foster WM,Hollingsworth JW,Tighe RM,Li X,Fessler MB,Garantziotis S
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunoprecipitation
Tue Jan 28 00:00:00 EST 2020
Andrographolide mitigates IL‑1β‑induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF‑κB signaling pathway.
Molecular medicine reports
Zhang L,Chen Q,Wang H,Yang J,Sheng S
Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot
Sat Dec 01 00:00:00 EST 2018
Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages.
PloS one
Bueno-Silva B,Kawamoto D,Ando-Suguimoto ES,Alencar SM,Rosalen PL,Mayer MP
48-2300 was used in Western Blotting to evaluate whether Brazilian red propolis attenuates the inflammatory effect of lipopolysaccharide on macrophages, and investigate the underlying mechanisms.
Wed Jul 06 00:00:00 EDT 2016
Vizantin inhibits endotoxin-mediated immune responses via the TLR 4/MD-2 complex.
Journal of immunology (Baltimore, Md. : 1950)
Oda M,Yamamoto H,Shibutani M,Nakano M,Yabiku K,Tarui T,Kameyama N,Shirakawa D,Obayashi S,Watanabe N,Nakase H,Suenaga M,Matsunaga Y,Nagahama M,Takahashi H,Imagawa H,Kurosawa M,Terao Y,Nishizawa M,Sakurai J
48-2300 was used in immunocytochemistry and western blot to investigate the effect of vizantin on endotoxin-mediated immune responses
Sat Nov 01 00:00:00 EDT 2014
TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy.
PloS one
Ma J,Chadban SJ,Zhao CY,Chen X,Kwan T,Panchapakesan U,Pollock CA,Wu H
48-2300 was used in immunohistochemistry - paraffin section to examine the contribution of TLR4 to diabetic nephropathy
Fri Jan 09 00:00:00 EST 2015
TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy.
PloS one
Ma J,Chadban SJ,Zhao CY,Chen X,Kwan T,Panchapakesan U,Pollock CA,Wu H
48-2300 was used in immunohistochemistry - paraffin section to examine the contribution of TLR4 to diabetic nephropathy
Fri Jan 09 00:00:00 EST 2015
TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy.
PloS one
Ma J,Chadban SJ,Zhao CY,Chen X,Kwan T,Panchapakesan U,Pollock CA,Wu H
48-2300 was used in immunohistochemistry - paraffin section to examine the contribution of TLR4 to diabetic nephropathy
Fri Jan 09 00:00:00 EST 2015
Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens.
Placenta
Arce RM,Barros SP,Wacker B,Peters B,Moss K,Offenbacher S
Sun Feb 01 00:00:00 EST 2009
Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori.
International journal of medical microbiology : IJMM
Schmausser B,Andrulis M,Endrich S,Müller-Hermelink HK,Eck M
Wed Jun 01 00:00:00 EDT 2005