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Product Details
H00010333-M05
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
2B10
Immunogen
TLR6 (NP_006059, 201 a.a. approximately 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK FLSELTRGST LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS
Target Information
TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 286; CD286; Toll-like receptor 6
Gene Aliases: CD286; TLR6
UniProt ID: (Human) Q9Y2C9
Entrez Gene ID: (Human) 10333
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
activation of NF-kappaB-inducing kinase activity
toll-like receptor 6 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
T-helper 1 type immune response
detection of diacyl bacterial lipopeptide
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
innate immune response
positive regulation of interleukin-6 biosynthetic process
interleukin-1 beta secretion
regulation of cytokine secretion
cellular response to diacyl bacterial lipopeptide
positive regulation of NLRP3 inflammasome complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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