Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
H00051284-M10
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1G8
Immunogen
TLR7 (NP_057646, 27 a.a. approximately 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: ARWFPKTLPC DVTLDVPKNH VIVDCTDKHL TEIPGGIPTN TTNLTLTINH IPDISPASFH RLDHLVEIDF RCNCVPIPLG SKNNMCIKRL QIKPRSFSGL
Target Information
TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: RP23-139P21.3; Toll-like receptor 7; toll-like receptor 7-like
Gene Aliases: TLR7; TLR7-like; UNQ248/PRO285
UniProt ID: (Human) Q9NYK1
Entrez Gene ID: (Human) 51284
microglial cell activation
regulation of protein phosphorylation
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
I-kappaB phosphorylation
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
positive regulation of NF-kappaB import into nucleus
positive regulation of interferon-gamma biosynthetic process
innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
positive regulation of inflammatory response
defense response to virus
cellular response to mechanical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support