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Product Details
PA5-17493
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Gly442 of human TLR9 protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10987365
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD289; Toll-like receptor 9
Gene Aliases: CD289; TLR9; UNQ5798/PRO19605
UniProt ID: (Human) Q9NR96
Entrez Gene ID: (Human) 54106
toll-like receptor signaling pathway
response to molecule of bacterial origin
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
I-kappaB phosphorylation
axonogenesis
positive regulation of gene expression
maintenance of gastrointestinal epithelium
negative regulation of NF-kappaB transcription factor activity
tumor necrosis factor production
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
positive regulation of chemokine production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
positive regulation of toll-like receptor signaling pathway
toll-like receptor 9 signaling pathway
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of NF-kappaB import into nucleus
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
positive regulation of interferon-gamma biosynthetic process
innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
regulation of cytokine secretion
positive regulation of inflammatory response
defense response to Gram-negative bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
negative regulation of calcium-transporting ATPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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