Invitrogen

TLR9 Polyclonal Antibody

View all (39) TLR9 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-89960

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 414-543 of human TLR9 (NP_0591381)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805867

Product Specific Information

Positive Samples: Mouse spleen, Rat spleen; Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome

Immunogen sequence: FPGLRYVDLS DNRISGASEL TATMGEADGG EKVWLQPGDL APAPVDTPSS EDFRPNCSTL NFTLDLSRNN LVTVQPEMFA QLSHLQCLRL SHNCISQAVN GSQFLPLTGL QVLDLSHNKL DLYHEHSFTE

Target Information

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD289; Toll-like receptor 9

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Gene Aliases: CD289; TLR9; UNQ5798/PRO19605

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UniProt ID: (Human) Q9NR96, (Mouse) Q9EQU3

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Entrez Gene ID: (Human) 54106, (Rat) 338457, (Mouse) 81897

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Function(s)
transmembrane signaling receptor activity interleukin-1 receptor binding 1-phosphatidylinositol-3-kinase activity siRNA binding unmethylated CpG binding protein binding
Process(es)
microglial cell activation regulation of protein phosphorylation toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway immune response I-kappaB phosphorylation male gonad development response to virus positive regulation of autophagy maintenance of gastrointestinal epithelium negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity positive regulation of interferon-gamma biosynthetic process innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of transcription from RNA polymerase II promoter regulation of cytokine secretion regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of NF-kappaB transcription factor activity defense response to virus positive regulation of nitric-oxide synthase biosynthetic process cellular response to lipopolysaccharide cellular response to metal ion response to molecule of bacterial origin immune system process regulation of dendritic cell cytokine production inflammatory response signal transduction positive regulation of gene expression tumor necrosis factor production positive regulation of granulocyte macrophage colony-stimulating factor production negative regulation of calcium-transporting ATPase activity axonogenesis phosphatidylinositol-3-phosphate biosynthetic process defense response to bacterium positive regulation of JNK cascade
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