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Product Details
PA5-86571
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 31-80 of Human TNF-beta.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803341
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
TNF beta, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAMA-25N12.13; LT-alpha; lymphotoxin A; lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin-alpha; TNF b; TNF beta; TNF superfamily, member 1; TNF β; TNF-beta; TNFbeta; TNFβ; tumor necrosis factor beta; tumor necrosis factor ligand 1E; Tumor necrosis factor ligand superfamily member 1
Gene Aliases: LT; LTA; TNFB; TNFSF1; TNLG1E
UniProt ID: (Human) P01374, (Rat) Q06332
Entrez Gene ID: (Human) 4049, (Rat) 25008
response to hypoxia
positive regulation of chronic inflammatory response to antigenic stimulus
positive regulation of humoral immune response mediated by circulating immunoglobulin
apoptotic process
humoral immune response
signal transduction
cell-cell signaling
response to nutrient
response to lipopolysaccharide
positive regulation of interferon-gamma production
tumor necrosis factor-mediated signaling pathway
response to drug
positive regulation of apoptotic process
negative regulation of growth of symbiont in host
negative regulation of fibroblast proliferation
lymph node development
defense response to Gram-positive bacterium
positive regulation of glial cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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