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TNFR2 Antibody (MA5-35276) in WB
Western blot analysis of TNFR2 in extracts of various cell lines. Samples were incubated with TNFR2 Monoclonal antibody (Product # MA5-35276) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
MA5-35276
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC0397
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 362-461 of human TNFR2/TNFRSF1B (P20333)
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849178
Product Specific Information
Immunogen sequence: RASTGSSDSS PGGHGTQVNV TCIVNVCSSS DHSSQCSSQA SSTMGDTDSS PSESPKDEQV PFSKEECAFR SQLETPETLL GSTEEKPLPL GVPDAGMKPS
Target Information
TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD120b; p75; p75 TNF receptor; p75 TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR1B variant 1; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TNF receptor beta chain; TNF-R2; TNF-RII; TNFR; TNFR II; TNFR-II; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II
Gene Aliases: CD120b; p75; p75TNFR; TBPII; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr-2; TNFR1B; TNFR2; TNFR80; TNFRII; TNFRSF1B
UniProt ID: (Human) P20333, (Rat) Q80WY6, (Mouse) P25119
Entrez Gene ID: (Human) 7133, (Rat) 156767, (Mouse) 21938
inflammatory response
immune response
multicellular organism development
aging
intrinsic apoptotic signaling pathway in response to DNA damage
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of inflammatory response
RNA destabilization
positive regulation of membrane protein ectodomain proteolysis
cellular response to lipopolysaccharide
cellular response to growth factor stimulus
apoptotic signaling pathway
extrinsic apoptotic signaling pathway
cell surface receptor signaling pathway
programmed cell death
response to lipopolysaccharide
cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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