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Product Details
PA5-144873
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 245-313. Recombinant protein control fragment (Product #RP-109854).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3092155
Product Specific Information
Immunogen sequence: SSQEQTFQLL KLWKHQNKDQ DIVKKIIQDI DLCENSVQRH IGHANLTFEQ LRSLMESLPG KKVGAEDIE
Antigen sequence identity: Mouse 81%; Rat 84%
Target Information
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC29565; Osteoclastogenesis inhibitory factor; Osteoprotegerin; soluble OPG; soluble Osteoprotegerin; sOPG; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
Gene Aliases: OCIF; OPG; PDB5; TNFRSF11B; TR1
UniProt ID: (Human) O00300
Entrez Gene ID: (Human) 4982
skeletal system development
inflammatory response
immune response
signal transduction
response to nutrient
extracellular matrix organization
response to magnesium ion
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
negative regulation of odontogenesis of dentin-containing tooth
response to drug
regulation of apoptotic process
positive regulation of MAPK cascade
response to estrogen
negative regulation of bone resorption
response to arsenic-containing substance
apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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