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TNFRSF14 Antibody (PA5-116056) in IHC (P)
Immunohistochemistry analysis of TNFRSF14 in human gastric cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-116056) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-116056
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TNFRSF14(Accession Q92956), corresponding to amino acid residues G220-E270.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900690
Product Specific Information
Antibody detects endogenous levels of total TNFRSF14.
Target Information
TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HGNC:11912; RP3-395M20.6; sCD2710; TR2; tumo; Tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2
Gene Aliases: ATAR; CD270; HVEA; HVEM; LIGHTR; TNFRSF14; TR2; UNQ329/PRO509
UniProt ID: (Human) Q92956
Entrez Gene ID: (Human) 8764, (Rat) 366518
positive regulation of cytokine secretion involved in immune response
inflammatory response
immune response
cell surface receptor signaling pathway
multicellular organism development
T cell costimulation
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of alpha-beta T cell proliferation
viral entry into host cell
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
apoptotic signaling pathway
positive regulation of T cell migration
biological_process
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