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Product Details
H00027242-M42
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4B6
Immunogen
TNFRSF21 (AAH17730.1, 47 a.a. approximately 214 a.a) partial recombinant protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: ASNLIGTYRH VDRATGQVLT CDKCPAGTYV SEHCTNTSLR VCSSCPVGTF TRHENGIEKC HDCSQPCPWP MIEKLPCAAL TDRECTCPPG MFQSNATCAP HTVCPVGWGV RKKGTETEDV RCKQCARGTF SDVPSSVMKC KAYTDCLSQN LVVIKPGTKE TDNVCGTL
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD358; Death receptor 6; Death receptor-6; MGC31965; sCD358; sDR6; soluble CD358; soluble DR6; TNFR-related death receptor 6; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
Gene Aliases: BM-018; CD358; DR6; TNFRSF21; UNQ437/PRO868
UniProt ID: (Human) O75509
Entrez Gene ID: (Human) 27242
B cell apoptotic process
adaptive immune response
apoptotic process
inflammatory response
immune response
humoral immune response
negative regulation of B cell proliferation
negative regulation of myelination
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
negative regulation of T cell proliferation
myelination
regulation of apoptotic process
regulation of oligodendrocyte differentiation
T cell receptor signaling pathway
neuron apoptotic process
cellular response to tumor necrosis factor
apoptotic signaling pathway
oligodendrocyte apoptotic process
negative regulation of interleukin-5 secretion
negative regulation of interleukin-13 secretion
negative regulation of interleukin-10 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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