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Immunogen sequence: MPEVERKPK ITASRKLLLK SLMLAKAKEC WEQEHEEREA EKVRYLAERI PTLQTRGLSL SALQDLCREL HAKVEVVDEE RYDIEAKCLH NTREIKDLKL KVMDLRGKFK RPPLRRVRVS ADAMLRALLG SKHKVSMDLR ANLKSVKKED TEKERPVEVG DWRKNVEAMS GMEGRKKMFD AAKSPTSQ (1-187 aa encoded by BC012600)
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
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Protein Aliases: SSTNI; TNN1; troponin I type 1 (skeletal, slow); troponin I, skeletal, slow 1; Troponin I, slow isoform; Troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform
Gene Aliases: 2700018B22Rik; AI747285; SSTNI; TNN1; TNNI1
UniProt ID: (Human) P19237, (Mouse) Q9WUZ5, (Rat) P13413
Entrez Gene ID: (Human) 7135, (Mouse) 21952, (Rat) 29388
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