Proteintech

TNNI1 Polyclonal Antibody

TNNI1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TNNI1 Antibody (16102-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 16102-1-AP ( TNNI1 Antibody) at dilution of 1:50 (under 40x lens).

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Product Details

16102-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TNNI1 Fusion Protein Ag9001 (1-187 aa encoded by BC012600)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPEVERKPK ITASRKLLLK SLMLAKAKEC WEQEHEEREA EKVRYLAERI PTLQTRGLSL SALQDLCREL HAKVEVVDEE RYDIEAKCLH NTREIKDLKL KVMDLRGKFK RPPLRRVRVS ADAMLRALLG SKHKVSMDLR ANLKSVKKED TEKERPVEVG DWRKNVEAMS GMEGRKKMFD AAKSPTSQ (1-187 aa encoded by BC012600)

Target Information

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Engineering of thick human functional myocardium via static stretching and electrical stimulation.

iScience

Pretorius D,Kahn-Krell AM,LaBarge WC,Lou X,Zhang J

Fri Mar 18 00:00:00 EDT 2022

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Basic research in cardiology

Hulikova A,Park KC,Loonat AA,Gunadasa-Rohling M,Curtis MK,Chung YJ,Wilson A,Carr CA,Trafford AW,Fournier M,Moshnikova A,Andreev OA,Reshetnyak YK,Riley PR,Smart N,Milne TA,Crump NT,Swietach P

Thu Mar 31 00:00:00 EDT 2022

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Basic research in cardiology

Hulikova A,Park KC,Loonat AA,Gunadasa-Rohling M,Curtis MK,Chung YJ,Wilson A,Carr CA,Trafford AW,Fournier M,Moshnikova A,Andreev OA,Reshetnyak YK,Riley PR,Smart N,Milne TA,Crump NT,Swietach P

Thu Mar 31 00:00:00 EDT 2022

Long noncoding RNA LINC00284 facilitates cell proliferation in papillary thyroid cancer via impairing miR-3127-5p targeted E2F7 suppression.

Cell death discovery

Zhou B,Ge Y,Shao Q,Yang L,Chen X,Jiang G

Sat Jun 26 00:00:00 EDT 2021

Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle.

Frontiers in physiology

Valentine WJ,Mostafa SA,Tokuoka SM,Hamano F,Inagaki NF,Nordin JZ,Motohashi N,Kita Y,Aoki Y,Shimizu T,Shindou H

Tue Feb 01 00:00:00 EST 2022

A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice.

Scientific reports

Ihara K,Sasano T,Hiraoka Y,Togo-Ohno M,Soejima Y,Sawabe M,Tsuchiya M,Ogawa H,Furukawa T,Kuroyanagi H

Tue Oct 27 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: SSTNI; TNN1; troponin I type 1 (skeletal, slow); troponin I, skeletal, slow 1; Troponin I, slow isoform; Troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform

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Gene Aliases: 2700018B22Rik; AI747285; SSTNI; TNN1; TNNI1

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UniProt ID: (Human) P19237, (Mouse) Q9WUZ5, (Rat) P13413

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Entrez Gene ID: (Human) 7135, (Mouse) 21952, (Rat) 29388

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Function(s)

actin binding protein binding metal ion binding non-motor actin binding protein

Process(es)

skeletal muscle contraction regulation of striated muscle contraction transition between fast and slow fiber muscle filament sliding ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction regulation of muscle contraction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TNNI1 Polyclonal Antibody

TNNI1 Antibody (16102-1-AP) in IHC (P)

Product Details

16102-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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