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Product Details
12205-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRIM27 Fusion Protein Ag2849 (165-514 aa encoded by BC013580)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EQARAELLS LTQMEREKIV WEFEQLYHSL KEHEYRLLAR LEELDLAIYN SINGAITQFS CNISHLSSLI AQLEEKQQQP TRELLQDIGD TLSRAERIRI PEPWITPPDL QEKIHIFAQK CLFLTESLKQ FTEKMQSDME KIQELREAQL YSVDVTLDPD TAYPSLILSD NLRQVRYSYL QQDLPDNPER FNLFPCVLGS PCFIAGRHYW EVEVGDKAKW TIGVCEDSVC RKGGVTSAPQ NGFWAVSLWY GKEYWALTSP MTALPLRTPL QRVGIFLDYD AGEVSFYNVT ERCHTFTFSH ATFCGPVRPY FSLSYSGGKS AAPLIICPMS GIDGFSGHVG NHGHSMETSP (165-514 aa encoded by BC013580)
Target Information
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ret finger protein; ret finger protein 1; RFP transforming protein; RING finger protein 76; tripartite motif protein 27; tripartite motif protein TRIM27; tripartite motif-containing 27; Tripartite motif-containing protein 27; Zinc finger protein RFP
Gene Aliases: AW538890; Gm19403; RFP; Rfp1; RNF76; TRIM27
UniProt ID: (Human) P14373, (Mouse) Q62158
Entrez Gene ID: (Human) 5987, (Mouse) 19720, (Rat) 291171
nucleic acid binding
DNA binding
transmembrane receptor protein tyrosine kinase activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
identical protein binding
metal ion binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
negative regulation of transcription from RNA polymerase II promoter
negative regulation of adaptive immune response
transcription, DNA-templated
negative regulation of protein kinase activity
spermatogenesis
cell proliferation
peptidyl-tyrosine phosphorylation
negative regulation of tumor necrosis factor production
negative regulation of viral transcription
Arp2/3 complex-mediated actin nucleation
retrograde transport, endosome to Golgi
innate immune response
negative regulation of gene expression, epigenetic
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of actin nucleation
protein trimerization
protein K63-linked ubiquitination
interferon-gamma secretion
negative regulation of calcium ion import
negative regulation of interleukin-2 secretion
negative regulation of viral release from host cell
regulation of transcription, DNA-templated
transport
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