Proteintech

TRIM63 Polyclonal Antibody

TRIM63 Antibody in Immunocytochemistry (ICC/IF)

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TRIM63 Antibody (55456-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 55456-1-AP (TRIM63 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

TRIM63 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

55456-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 56 publications 56 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.67 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to TRIM63.

Target Information

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Spermidine-Activated Satellite Cells Are Associated with Hypoacetylation in ACVR2B and Smad3 Binding to Myogenic Genes in Mice.

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Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice.

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Singh RK,Kolonin AM,Fiorotto ML,Cooper TA

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Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.

Oncotarget

Guo D,Wang C,Wang Q,Qiao Z,Tang H

Tue Jun 13 00:00:00 EDT 2017

Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.

Oncotarget

Guo D,Wang C,Wang Q,Qiao Z,Tang H

Tue Jun 13 00:00:00 EDT 2017

Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.

Oncotarget

Guo D,Wang C,Wang Q,Qiao Z,Tang H

Tue Jun 13 00:00:00 EDT 2017

Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.

Oncotarget

Guo D,Wang C,Wang Q,Qiao Z,Tang H

Tue Jun 13 00:00:00 EDT 2017

Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis.

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Miao C,Lv Y,Zhang W,Chai X,Feng L,Fang Y,Liu X,Zhang X

Wed Mar 30 00:00:00 EDT 2022

Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis.

Frontiers in pharmacology

Miao C,Lv Y,Zhang W,Chai X,Feng L,Fang Y,Liu X,Zhang X

Wed Mar 30 00:00:00 EDT 2022

Asparagine reduces the mRNA expression of muscle atrophy markers via regulating protein kinase B (Akt), AMP-activated protein kinase α, toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling in weaning piglets after lipopolysaccharide challenge.

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Sat Oct 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRIM63; FLJ32380; Iris RING finger protein; MURF 1; MURF-1; muscle ring finger protein 1; muscle specific ring finger protein 2; Muscle-specific RING finger protein 1; OTTHUMP00000008701; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; RNF 28; Striated muscle RING zinc finger protein; TRIM 63; tripartite motif containing 63, E3 ubiquitin protein ligase; tripartite motif protein 63; tripartite motif-containing 63; Tripartite motif-containing protein 63

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Gene Aliases: IRF; Murf; MURF1; MURF2; RF1; RNF28; SMRZ; TRIM63

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UniProt ID: (Human) Q969Q1, (Rat) Q91Z63

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Entrez Gene ID: (Human) 84676, (Rat) 140939, (Mouse) 433766

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Function(s)

ubiquitin-protein transferase activity signal transducer activity protein binding zinc ion binding ligase activity titin binding ubiquitin protein ligase activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase

Process(es)

muscle contraction signal transduction skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation protein ubiquitination response to glucocorticoid response to interleukin-1 regulation of gene expression response to denervation involved in regulation of muscle adaptation proteasome-mediated ubiquitin-dependent protein catabolic process cellular response to dexamethasone stimulus

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRIM63 Polyclonal Antibody

TRIM63 Antibody (55456-1-AP) in ICC/IF

Product Details

55456-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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