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Invitrogen
TROP2 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 7
TROP2 Antibody (PA5-47074) in ICC/IF
Immunocytochemistry analysis of TROP2 in immersion fixed XB2 mouse teratoma keratinocyte cell line. Samples were incubated in TROP2 polyclonal antibody (Product # PA5-47074) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (yellow) and counterstained with DAPI (blue).
Product Details
PA5-47074
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TROP-2 Ser82-Thr268
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606931
Product Specific Information
In direct ELISAs, approximately 30% cross-reactivity with recombinant human TROP-2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 40kD glycoprotein, identified by monoclonal antibody GA733; Cell surface glycoprotein Trop-2; cell surface glycoprotein TROP2; epithelial glycoprotein-1; GA733; gastrointestinal tumor-associated antigen GA7331; lymphocyte antigen 97; Membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; Pancreatic carcinoma marker protein GA733-1; pancreatic carcinoma marker protein GA7331; Parturition-related protein 1; TACD2; truncated TACSTD2; Tumor-associated calcium signal transducer 2; tunor-associated calcium signal transducer 2
Gene Aliases: C80403; EGP-1; EGP1; GA733-1; GA7331; GP50; Ly97; M1S1; Prp1; TACSTD2; TROP2
UniProt ID: (Human) P09758, (Rat) Q6P9Z6, (Mouse) Q8BGV3
Entrez Gene ID: (Human) 4070, (Rat) 494343, (Mouse) 56753
biological_process
negative regulation of epithelial cell migration
regulation of epithelial cell proliferation
negative regulation of stress fiber assembly
ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of ruffle assembly
negative regulation of cell motility
positive regulation of stem cell differentiation
cell surface receptor signaling pathway
visual perception
cell proliferation
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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