Proteintech

TRPV1 Monoclonal Antibody (1A3C9)

FIGURE: 1 / 1

TRPV1 Antibody (66983-1-IG) in WB

HepG2 cells were subjected to SDS PAGE followed by western blot with 66983-1-Ig (TRPV1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

66983-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:3,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1A3C9

Immunogen

TRPV1 Fusion Protein Ag18683

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Thermo-TRP channels are involved in BAT thermoregulation in cold-acclimated Brandt's voles.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

Lv J,Tang L,Zhang X,Wang D

Sun Jan 01 00:00:00 EST 2023

Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.

Nature communications

Li T,Jiang S,Zhang Y,Luo J,Li M,Ke H,Deng Y,Yang T,Sun X,Chen H

Sat Apr 29 00:00:00 EDT 2023

Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.

Nature communications

Li T,Jiang S,Zhang Y,Luo J,Li M,Ke H,Deng Y,Yang T,Sun X,Chen H

Sat Apr 29 00:00:00 EDT 2023

Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats.

Molecular neurobiology

Liu L,Zhao Y,An W,Zhao M,Ding N,Liu H,Ge N,Wen J,Zhang X,Zu S,Sun W

Fri Sep 01 00:00:00 EDT 2023

Smart nanostructures for targeted oxygen-producing photodynamic therapy of skin photoaging and potential mechanism.

Nanomedicine (London, England)

Wang Y,Lu Z,Huang Y,Jia W,Wang W,Zhang X,Chen C,Li Y,Yang C,Jiang G

Wed Feb 01 00:00:00 EST 2023

Effect of Xiongmatang Extract on Behavioral and TRPV1-CGRP/CGRP-R Pathway in Rats With Migraine.

Frontiers in pharmacology

Liu D,Chang L,Wang J,Zhu Q,Jiang N,Azhar M,Ahmed A,Zeng G

Fri Apr 01 00:00:00 EDT 2022

Effect of Xiongmatang Extract on Behavioral and TRPV1-CGRP/CGRP-R Pathway in Rats With Migraine.

Frontiers in pharmacology

Liu D,Chang L,Wang J,Zhu Q,Jiang N,Azhar M,Ahmed A,Zeng G

Fri Apr 01 00:00:00 EDT 2022

Cannabidiol Inhibits Inflammation Induced by Cutibacterium acnes-Derived Extracellular Vesicles via Activation of CB2 Receptor in Keratinocytes.

Journal of inflammation research

Jiang Z,Jin S,Fan X,Cao K,Liu Y,Wang X,Ma Y,Xiang L

Sat Aug 20 00:00:00 EDT 2022

Noninvasive near-infrared light triggers the remote activation of thermo-responsive TRPV1 channels in neurons based on biodegradable/photothermal polymer micelles.

Nanoscale

Chen WH,Onoe T,Kamimura M

Thu Feb 10 00:00:00 EST 2022

Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats.

Molecular pain

Liu Y,Zhang L,Xu ZH,Zhu J,Ma JL,Gao YP,Xu GY

Fri Apr 01 00:00:00 EDT 2022

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.

EBioMedicine

Lv Z,Han J,Li J,Guo H,Fei Y,Sun Z,Dong J,Wang M,Fan C,Li W,Xie Y,Sun W,Chen J,Liu Y,Chen F,Liu Z,Liu A,Wu R,Xu X,Yan W,Jiang Q,Ikegawa S,Chen X,Shi D

Sat Oct 01 00:00:00 EDT 2022

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.

EBioMedicine

Lv Z,Han J,Li J,Guo H,Fei Y,Sun Z,Dong J,Wang M,Fan C,Li W,Xie Y,Sun W,Chen J,Liu Y,Chen F,Liu Z,Liu A,Wu R,Xu X,Yan W,Jiang Q,Ikegawa S,Chen X,Shi D

Sat Oct 01 00:00:00 EDT 2022

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.

EBioMedicine

Lv Z,Han J,Li J,Guo H,Fei Y,Sun Z,Dong J,Wang M,Fan C,Li W,Xie Y,Sun W,Chen J,Liu Y,Chen F,Liu Z,Liu A,Wu R,Xu X,Yan W,Jiang Q,Ikegawa S,Chen X,Shi D

Sat Oct 01 00:00:00 EDT 2022

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.

EBioMedicine

Lv Z,Han J,Li J,Guo H,Fei Y,Sun Z,Dong J,Wang M,Fan C,Li W,Xie Y,Sun W,Chen J,Liu Y,Chen F,Liu Z,Liu A,Wu R,Xu X,Yan W,Jiang Q,Ikegawa S,Chen X,Shi D

Sat Oct 01 00:00:00 EDT 2022

The Contribution of TSLP Activation to Hyperalgesia in Dorsal Root Ganglia Neurons of a Rat.

International journal of molecular sciences

Lu CC,Lu YY,Tsai HP,Wu CH

Fri Feb 11 00:00:00 EST 2022

Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome.

Frontiers in pharmacology

Wang NN,Zhang XX,Shen P,Huang CS,Deng HF,Zhou L,Yue LX,Shen BY,Zhou W,Gao Y

Wed Sep 07 00:00:00 EDT 2022

Functional Characterization of Ovine Dorsal Root Ganglion Neurons Reveal Peripheral Sensitization after Osteochondral Defect.

eNeuro

Chakrabarti S,Ai M,Wong K,Newell K,Henson FMD,Smith ESJ

Wed Oct 20 00:00:00 EDT 2021

Effect of local ozone treatment on rats with anterior rectal resection and the possible mechanisms.

Biomedical engineering online

Zhang W,Wu M,Chen P,Zhang J,Ma J,Cheng Y,Li X,Hu J,Li W,Du Y,Ding K,Fan Z

Fri Aug 06 00:00:00 EDT 2021

Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury.

Cell calcium

Liu Z,Wang P,Lu S,Guo R,Gao W,Tong H,Yin Y,Han X,Liu T,Chen X,Zhu MX,Yang Z

Tue Apr 28 00:00:00 EDT 2020

Bioinformatics

Protein Aliases: Capsaicin receptor; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1

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Gene Aliases: TRPV1; VR1

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UniProt ID: (Human) Q9NQ74

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Entrez Gene ID: (Human) 7442

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Function(s)

transmembrane signaling receptor activity excitatory extracellular ligand-gated ion channel activity calcium channel activity calmodulin binding ATP binding calcium-release channel activity phosphoprotein binding ion channel

Process(es)

transport cell surface receptor signaling pathway chemosensory behavior thermoception release of sequestered calcium ion into cytosol calcium ion transmembrane transport cellular response to alkaloid cellular response to ATP

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRPV1 Monoclonal Antibody (1A3C9)

TRPV1 Antibody (66983-1-IG) in WB

Product Details

66983-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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