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Product Details
H00059341-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4E11
Immunogen
TRPV4 (NP_067638.3, 772 a.a. approximately 871 a.a) partial recombinant protein with GST-pstS1 tag.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: PDRRWCFRVD EVNWSHWNQN LGIINEDPGK NETYQYYGFS HTVGRLRRDR WSSVVPRVVE LNKNSNPDEV VVPLDSMGNP RCDGHQQGYP RKWRTDDAPL
Target Information
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Osm-9-like TRP channel 4; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily V, member 4; Transient receptor potential protein 12; TRP12; TrpV4; Vanilloi; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL-2
Gene Aliases: BCYM3; CMT2C; HMSN2C; OTRPC4; SMAL; SPSMA; SSQTL1; TRP12; TRPV4; VRL2; VROAC
UniProt ID: (Human) Q9HBA0
Entrez Gene ID: (Human) 59341
actin binding
osmosensor activity
protein kinase C binding
cation channel activity
calcium channel activity
protein binding
calmodulin binding
ATP binding
microtubule binding
stretch-activated, cation-selective, calcium channel activity
protein kinase binding
SH2 domain binding
alpha-tubulin binding
beta-tubulin binding
actin filament binding
ion channel
negative regulation of transcription from RNA polymerase II promoter
diet induced thermogenesis
calcium ion transport
cellular calcium ion homeostasis
cell volume homeostasis
actin filament organization
cell-cell junction assembly
positive regulation of cytosolic calcium ion concentration
osmosensory signaling pathway
response to mechanical stimulus
positive regulation of gene expression
positive regulation of macrophage chemotaxis
negative regulation of neuron projection development
vasopressin secretion
positive regulation of microtubule depolymerization
actin cytoskeleton reorganization
response to insulin
cellular response to heat
hyperosmotic salinity response
glucose homeostasis
positive regulation of vascular permeability
cortical microtubule organization
positive regulation of JNK cascade
microtubule polymerization
regulation of response to osmotic stress
positive regulation of inflammatory response
multicellular organismal water homeostasis
positive regulation of ERK1 and ERK2 cascade
calcium ion import
calcium ion transmembrane transport
cellular response to osmotic stress
cellular hypotonic response
cellular hypotonic salinity response
positive regulation of monocyte chemotactic protein-1 production
positive regulation of macrophage inflammatory protein 1 alpha production
positive regulation of chemokine (C-C motif) ligand 5 production
blood vessel endothelial cell delamination
negative regulation of brown fat cell differentiation
signal transduction involved in regulation of aerobic respiration
positive regulation of chemokine (C-X-C motif) ligand 1 production
positive regulation of energy homeostasis
positive regulation of interleukin-6 secretion
Performance Guarantee
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