Product References
MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma.
PloS one
Danielson LS,Guijarro MV,Menendez S,Higgins B,Sun Q,Mittal K,Popiolek DA,Overholtzer M,Palmer GD,Hernando E
Published figure using TSC1 monoclonal antibody (Product # 37-0400) in Western Blot
Mon Jan 30 00:00:00 EST 2023
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Cell
Prentzell MT,Rehbein U,Cadena Sandoval M,De Meulemeester AS,Baumeister R,Brohée L,Berdel B,Bockwoldt M,Carroll B,Chowdhury SR,von Deimling A,Demetriades C,Figlia G,de Araujo MEG,Heberle AM,Heiland I,Holzwarth B,Huber LA,Jaworski J,Kedra M,Kern K,Kopach A,Korolchuk VI,van 't Land-Kuper I,Macias M,Nellist M,Palm W,Pusch S,Ramos Pittol JM,Reil M,Reintjes A,Reuter F,Sampson JR,Scheldeman C,Siekierska A,Stefan E,Teleman AA,Thomas LE,Torres-Quesada O,Trump S,West HD,de Witte P,Woltering S,Yordanov TE,Zmorzynska J,Opitz CA,Thedieck K
37-0400 was used in Immunoprecipitation to report that Ras GTPase-activating protein-binding proteins 1 and 2 reside at the cytoplasmic surface of lysosomes.
Thu Feb 04 00:00:00 EST 2021
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Cell
Prentzell MT,Rehbein U,Cadena Sandoval M,De Meulemeester AS,Baumeister R,Brohée L,Berdel B,Bockwoldt M,Carroll B,Chowdhury SR,von Deimling A,Demetriades C,Figlia G,de Araujo MEG,Heberle AM,Heiland I,Holzwarth B,Huber LA,Jaworski J,Kedra M,Kern K,Kopach A,Korolchuk VI,van 't Land-Kuper I,Macias M,Nellist M,Palm W,Pusch S,Ramos Pittol JM,Reil M,Reintjes A,Reuter F,Sampson JR,Scheldeman C,Siekierska A,Stefan E,Teleman AA,Thomas LE,Torres-Quesada O,Trump S,West HD,de Witte P,Woltering S,Yordanov TE,Zmorzynska J,Opitz CA,Thedieck K
37-0400 was used in Immunoprecipitation to report that Ras GTPase-activating protein-binding proteins 1 and 2 reside at the cytoplasmic surface of lysosomes.
Thu Feb 04 00:00:00 EST 2021
The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses.
The EMBO journal
Ko CJ,Zhang L,Jie Z,Zhu L,Zhou X,Xie X,Gao T,Yang JY,Cheng X,Sun SC
37-0400 was used in Immunoprecipitation to establish Peli1 as a novel regulator of mTORC1 and downstream mTORC1-mediated actions on T cell metabolism and antitumor immunity.
Fri Jan 15 00:00:00 EST 2021
MicroRNA-92b-3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma.
Cancer science
Wang C,Uemura M,Tomiyama E,Matsushita M,Koh Y,Nakano K,Hayashi Y,Ishizuya Y,Jingushi K,Kato T,Hatano K,Kawashima A,Ujike T,Nagahara A,Fujita K,Imamura R,Tsujikawa K,Nonomura N
37-0400 was used in Immunohistochemistry to investigate the role of miR-92b-3p in ccRCC.
Wed Apr 01 00:00:00 EDT 2020
MicroRNA-92b-3p is a prognostic oncomiR that targets TSC1 in clear cell renal cell carcinoma.
Cancer science
Wang C,Uemura M,Tomiyama E,Matsushita M,Koh Y,Nakano K,Hayashi Y,Ishizuya Y,Jingushi K,Kato T,Hatano K,Kawashima A,Ujike T,Nagahara A,Fujita K,Imamura R,Tsujikawa K,Nonomura N
37-0400 was used in Immunohistochemistry to investigate the role of miR-92b-3p in ccRCC.
Wed Apr 01 00:00:00 EDT 2020
miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model.
International journal of molecular sciences
Streleckiene G,Inciuraite R,Juzenas S,Salteniene V,Steponaitiene R,Gyvyte U,Kiudelis G,Leja M,Ruzgys P,Satkauskas S,Kupcinskiene E,Franke S,Thon C,Link A,Kupcinskas J,Skieceviciene J
Published figure using TSC1 monoclonal antibody (Product # 37-0400) in Western Blot
Wed Jan 29 00:00:00 EST 2020
R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.
Nature communications
Cloutier P,Poitras C,Durand M,Hekmat O,Fiola-Masson É,Bouchard A,Faubert D,Chabot B,Coulombe B
Published figure using TSC1 monoclonal antibody (Product # 37-0400) in Western Blot
Wed May 31 00:00:00 EDT 2017
Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy.
Cell cycle (Georgetown, Tex.)
Valianou M,Cox AM,Pichette B,Hartley S,Paladhi UR,Astrinidis A
37-0400 was used in western blot to elucidate how PLK1 regulates cell survival during mTORC1 hyperactivation.
Wed Dec 02 00:00:00 EST 2015
Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy.
Cell cycle (Georgetown, Tex.)
Valianou M,Cox AM,Pichette B,Hartley S,Paladhi UR,Astrinidis A
37-0400 was used in western blot to elucidate how PLK1 regulates cell survival during mTORC1 hyperactivation.
Wed Dec 02 00:00:00 EST 2015
Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy.
Cell cycle (Georgetown, Tex.)
Valianou M,Cox AM,Pichette B,Hartley S,Paladhi UR,Astrinidis A
37-0400 was used in western blot to elucidate how PLK1 regulates cell survival during mTORC1 hyperactivation.
Wed Dec 02 00:00:00 EST 2015
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Cell
Menon S,Dibble CC,Talbott G,Hoxhaj G,Valvezan AJ,Takahashi H,Cantley LC,Manning BD
Published figure using TSC1 monoclonal antibody (Product # 37-0400) in Immunoprecipitation
Thu Feb 13 00:00:00 EST 2014
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
The Journal of experimental medicine
Liang N,Zhang C,Dill P,Panasyuk G,Pion D,Koka V,Gallazzini M,Olson EN,Lam H,Henske EP,Dong Z,Apte U,Pallet N,Johnson RL,Terzi F,Kwiatkowski DJ,Scoazec JY,Martignoni G,Pende M
Published figure using TSC1 monoclonal antibody (Product # 37-0400) in Immunohistochemistry
Mon Oct 20 00:00:00 EDT 2014
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.
The Journal of experimental medicine
Liang N,Zhang C,Dill P,Panasyuk G,Pion D,Koka V,Gallazzini M,Olson EN,Lam H,Henske EP,Dong Z,Apte U,Pallet N,Johnson RL,Terzi F,Kwiatkowski DJ,Scoazec JY,Martignoni G,Pende M
Published figure using TSC1 monoclonal antibody (Product # 37-0400) in Immunohistochemistry
Mon Oct 20 00:00:00 EDT 2014
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Molecular cell
Dibble CC,Elis W,Menon S,Qin W,Klekota J,Asara JM,Finan PM,Kwiatkowski DJ,Murphy LO,Manning BD
Fri Aug 24 00:00:00 EDT 2012
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Molecular cell
Dibble CC,Elis W,Menon S,Qin W,Klekota J,Asara JM,Finan PM,Kwiatkowski DJ,Murphy LO,Manning BD
Fri Aug 24 00:00:00 EDT 2012
Hepatitis B virus X protein upregulates mTOR signaling through IKKβ to increase cell proliferation and VEGF production in hepatocellular carcinoma.
PloS one
Yen CJ,Lin YJ,Yen CS,Tsai HW,Tsai TF,Chang KY,Huang WC,Lin PW,Chiang CW,Chang TT
37-0400 was used in western blot to study signaling pathways underlying HBx-induced liver tumorigenesis.
Thu Jan 10 00:00:00 EST 2013
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Science signaling
Kuo HP,Lee DF,Chen CT,Liu M,Chou CK,Lee HJ,Du Y,Xie X,Wei Y,Xia W,Weihua Z,Yang JY,Yen CJ,Huang TH,Tan M,Xing G,Zhao Y,Lin CH,Tsai SF,Fidler IJ,Hung MC
37-0400 was used in western blot to suggest ARD inhibits the mTOR pathway.
Tue Feb 09 00:00:00 EST 2010
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Science signaling
Kuo HP,Lee DF,Chen CT,Liu M,Chou CK,Lee HJ,Du Y,Xie X,Wei Y,Xia W,Weihua Z,Yang JY,Yen CJ,Huang TH,Tan M,Xing G,Zhao Y,Lin CH,Tsai SF,Fidler IJ,Hung MC
37-0400 was used in western blot to suggest ARD inhibits the mTOR pathway.
Tue Feb 09 00:00:00 EST 2010
Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.
Genes to cells : devoted to molecular & cellular mechanisms
Kume K,Iizumi Y,Shimada M,Ito Y,Kishi T,Yamaguchi Y,Handa H
Thu Apr 01 00:00:00 EDT 2010
Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.
Genes to cells : devoted to molecular & cellular mechanisms
Kume K,Iizumi Y,Shimada M,Ito Y,Kishi T,Yamaguchi Y,Handa H
Thu Apr 01 00:00:00 EDT 2010
The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.
Human molecular genetics
Hartman TR,Liu D,Zilfou JT,Robb V,Morrison T,Watnick T,Henske EP
37-0400 was used in immunocytochemistry and western blot to characterize the ciliary disruption in tuberous sclerosis complex syndrome
Thu Jan 01 00:00:00 EST 2009
The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.
Human molecular genetics
Hartman TR,Liu D,Zilfou JT,Robb V,Morrison T,Watnick T,Henske EP
37-0400 was used in immunocytochemistry and western blot to characterize the ciliary disruption in tuberous sclerosis complex syndrome
Thu Jan 01 00:00:00 EST 2009
Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex.
Neuropathology : official journal of the Japanese Society of Neuropathology
Boer K,Troost D,Jansen F,Nellist M,van den Ouweland AM,Geurts JJ,Spliet WG,Crino P,Aronica E
37-0400 was used in immunohistochemistry - paraffin section to report the neuropathological findings of a 32-year-old patient with a germ-line mutation in the TSC2 gene
Mon Dec 01 00:00:00 EST 2008
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
Cell
Lee DF,Kuo HP,Chen CT,Hsu JM,Chou CK,Wei Y,Sun HL,Li LY,Ping B,Huang WC,He X,Hung JY,Lai CC,Ding Q,Su JL,Yang JY,Sahin AA,Hortobagyi GN,Tsai FJ,Tsai CH,Hung MC
37-0400 was used in western blot to investigate inflammation-mediated tumor angiogenesis
Fri Aug 10 00:00:00 EDT 2007