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Product Details
AHO1422
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG, kappa
Class
Monoclonal
Type
Antibody
Clone
75R23
Immunogen
Recombinant fragment of human Tuberin expressed in E. coli.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
purified
Storage buffer
PBS with 1% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2536339
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2), is implicated as a tumor suppressor and may function in vesicular transport, play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser 939 and Thr 1462 regulates its interaction with hamartin, and is stimulated by various growth factors through the phosphoinositide 3-kinase/Akt pathway. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. TSC2 specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000198394; protein phosphatase 1, regulatory subunit 160; renal carcinoma; Tsc2; Tuberin; tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog
Gene Aliases: LAM; Nafld; PPP1R160; Rc; Tcs2; TSC2; TSC4
UniProt ID: (Human) P49815, (Rat) P49816
Entrez Gene ID: (Human) 7249, (Rat) 24855, (Mouse) 22084
neural tube closure
negative regulation of protein kinase activity
protein import into nucleus
endocytosis
cell cycle arrest
heart development
protein localization
negative regulation of cell proliferation
negative regulation of phosphatidylinositol 3-kinase signaling
viral process
vesicle-mediated transport
regulation of endocytosis
negative regulation of Wnt signaling pathway
negative regulation of TOR signaling
protein kinase B signaling
positive regulation of GTPase activity
regulation of insulin receptor signaling pathway
negative regulation of insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
positive chemotaxis
regulation of small GTPase mediated signal transduction
regulation of cell cycle
negative regulation of protein kinase B signaling
response to hypoxia
acute-phase response
signal transduction
phosphatidylinositol 3-kinase signaling
cell projection organization
cellular response to insulin stimulus
negative regulation of MAP kinase activity
protein transport into plasma membrane raft
establishment of protein localization
negative regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
glucose import
negative regulation of epithelial cell proliferation
protein homooligomerization
protein heterooligomerization
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