Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MSGGKKKSSF QITSVTTDYE GPGSPGASDP PTPQPPTGPP PRLPNGEPSP DPGGKGTPRN GSPPPGAPSS RFRVVKLPHG LGEPYRRGRW TCVDVYERDL EPHSFGGLLE GIRGASGGAG GRSLDSRLEL ASLGLGAPTP PSGLSQGPTS WLRPPPTSPG PQARSFTGGL GQLVVPSKAK AEKPPLSASS PQQRPPEPET GESAGTSRAA TPLPSLRVEA EAGGSGARTP PLSRRKAVDM RLRMELGAPE EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMFAVREE VEVLKEQIRE LAERNAALEQ ENGLLRALAS PEQLAQLPSS GVPRLGPPAP NGPSV
TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TSC22D1.
Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: tsc-22-like protein THG-1; TSC22 domain family protein 4; TSC22 domain family, member 4; TSC22-related-inducible leucine zipper protein 2
Gene Aliases: THG-1; THG1; THG1-PIT; TILZ2; TSC22D4
UniProt ID: (Human) Q9Y3Q8
Entrez Gene ID: (Human) 81628
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support