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Product Details
13321-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TSG-6 Fusion Protein Ag3885 (1-277 aa encoded by BC030205)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MIILIYLFL LLWEDTQGWG FKDGIFHNSI WLERAAGVYH REARSGKYKL TYAEAKAVCE FEGGHLATYK QLEAARKIGF HVCAAGWMAK GRVGYPIVKP GPNCGFGKTG IIDYGIRLNR SERWDAYCYN PHAKECGGVF TDPKQIFKSP GFPNEYEDNQ ICYWHIRLKY GQRIHLSFLD FDLEDDPGCL ADYVEIYDSY DDVHGFVGRY CGDELPDDII STGNVMTLKF LSDASVTAGG FQIKYVAMDP VSKSSQGKNT STTSTGNKNF LAGRFSHL (1-277 aa encoded by BC030205)
Target Information
The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNF alpha, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (I alpha I)). TSG-6 potentiates the inhibitory effect of l alpha l on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and l alpha l can modulate the protease network and thus inhibit inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Hyaluronate-binding protein; TNF alpha-induced protein 6; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; tumor necrosis factor alpha-inducible protein 6; tumor necrosis factor induced protein 6; tumor necrosis factor, alpha induced protein 6; tumor necrosis factor, alpha-induced protein 6; Tumor necrosis factor-inducible gene 6 protein; tumor necrosis factor-stimulated gene-6 protein
Gene Aliases: TNFAIP6; Tnfip6; TSG-6; TSG6
UniProt ID: (Human) P98066, (Mouse) O08859
Entrez Gene ID: (Human) 7130, (Mouse) 21930, (Rat) 84397
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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