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TWEAK Antibody (MA5-28606) in Flow
Flow Cytometry analysis of TWEAK using TWEAK Monoclonal Antibody (CARL-1) (Product # MA5-28606). Separation of CD255 transfected l5178Y cells (red-filled) from CD255 nontransfected (WT) l5178Y cells (black-dashed) in flow cytometry analysis (surface staining) of l5178Y cell suspensions stained using anti-human TWEAK (CARL-1) purified antibody (concentration in sample 3 μg/mL) GAM PE.
Product Details
MA5-28606
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
CARL-1
Immunogen
human CD255-transfected 2PK-3 cells
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 8.0
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745565
Product Specific Information
This antibody recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APO3 ligand; APO3/DR3 ligand; MGC129581; MGC20669; TNF-related WEAK inducer of apoptosis; tumor necrosis factor (ligand) superfamily member 12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand 4A; Tumor necrosis factor ligand superfamily member 12; TWEAK
Gene Aliases: APO3L; DR3LG; TNFSF12; TNLG4A; TWEAK; UNQ181/PRO207
UniProt ID: (Human) O43508
Entrez Gene ID: (Human) 8742
angiogenesis
positive regulation of endothelial cell proliferation
apoptotic process
immune response
signal transduction
cell differentiation
tumor necrosis factor-mediated signaling pathway
endothelial cell migration
positive regulation of protein catabolic process
positive regulation of angiogenesis
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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