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Invitrogen
TWEAK Chimeric Recombinant Rabbit Monoclonal Antibody (MTW-1)
FIGURE: 1 / 1
TWEAK Chimeric Antibody (MA5-48229) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of TWEAK in mouse splenocytes using TWEAK Chimeric Monoclonal Antibody (Product # MA5-48229). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with TWEAK Chimeric Monoclonal Antibody at 10 µg/mL followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane staining in subset of cells. The nuclear stain is DAPI (blue). Panel... View More
Product Details
MA5-48229
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MTW-1
Immunogen
This antibody was raised by immunising SD rats with CD8-mTWEAK, a fusion of the human CD8alpha extracellular region to murine TWEAK.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074672
Product Specific Information
Specificity: This antibody is specific for murine TWEAK. It has been shown not to react with TNF-alpha, FasL, and TRAIL.
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC129581; MGC20669; TNF-related weak inducer of apoptosis; Tumor necrosis factor ligand superfamily member 12; TWEAK
Gene Aliases: Apo3l; Dr3l; Dr3lg; Tnfsf12; Tweak
UniProt ID: (Mouse) O54907
Entrez Gene ID: (Mouse) 21944
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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