Product References
A prognostic risk model, tumor immune environment modulation, and drug prediction of ferroptosis and amino acid metabolism-related genes in hepatocellular carcinoma.
Human cell
Ji L,Zhang Q,Cao Y,Liu L
Mon May 01 00:00:00 EDT 2023
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
Nature cell biology
Navickas A,Asgharian H,Winkler J,Fish L,Garcia K,Markett D,Dodel M,Culbertson B,Miglani S,Joshi T,Yin K,Nguyen P,Zhang S,Stevers N,Hwang HW,Mardakheh F,Goga A,Goodarzi H
Thu Jun 01 00:00:00 EDT 2023
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Biochemical pharmacology
Li Y,She W,Guo T,Huang T,Liu Y,Liu P,Xu X,Wang X,Wang M,Yu C,Liu Y,Wei Y
Wed Feb 01 00:00:00 EST 2023
Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors.
European journal of medicinal chemistry
Zhou J,Yu LZ,Fan YL,Guo CH,Lv XM,Zhou ZY,Huang HD,Miao DD,Zhang SP,Li XY,Zhao PP,Liu XP,Hu WH,Zhang C
Thu Jan 05 00:00:00 EST 2023
Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway.
International journal of molecular sciences
Li Z,Gu Z,Wang L,Guan Y,Lyu Y,Zhang J,Wang Y,Wang X,Xiong J,Liu Y
Sat May 27 00:00:00 EDT 2023
SERD-NHC-Au(I) complexes for dual targeting ER and TrxR to induce ICD in breast cancer.
Pharmacological research
Lu Y,Sheng X,Liu C,Liang Z,Wang X,Liu L,Wen Z,Yang Z,Du Q,Liu W
Sat Apr 01 00:00:00 EDT 2023
Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
Oxidative medicine and cellular longevity
Huang Q,Peng M,Gu Y,Wu J,Zhan Y,Deng Z,Chen S,Yang R,Chen J,Xie J
Fri Dec 30 00:00:00 EST 2022
Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
Oxidative medicine and cellular longevity
Huang Q,Peng M,Gu Y,Wu J,Zhan Y,Deng Z,Chen S,Yang R,Chen J,Xie J
Fri Dec 30 00:00:00 EST 2022
Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
Oxidative medicine and cellular longevity
Huang Q,Peng M,Gu Y,Wu J,Zhan Y,Deng Z,Chen S,Yang R,Chen J,Xie J
Fri Dec 30 00:00:00 EST 2022
Metabolism-Related Gene TXNRD1 Regulates Inflammation and Oxidative Stress Induced by Cigarette Smoke through the Nrf2/HO-1 Pathway in the Small Airway Epithelium.
Oxidative medicine and cellular longevity
Huang Q,Peng M,Gu Y,Wu J,Zhan Y,Deng Z,Chen S,Yang R,Chen J,Xie J
Fri Dec 30 00:00:00 EST 2022
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation.
Redox biology
Gallego-Selles A,Galvan-Alvarez V,Martinez-Canton M,Garcia-Gonzalez E,Morales-Alamo D,Santana A,Gonzalez-Henriquez JJ,Dorado C,Calbet JAL,Martin-Rincon M
Thu Sep 01 00:00:00 EDT 2022
Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Biological trace element research
Lin T,Tao J,Chen Y,Zhang Y,Li F,Zhang Y,Han X,Zhao Z,Liu G,Li H
Tue Mar 01 00:00:00 EST 2022
Nanoparticle delivery of miR-21-3p sensitizes melanoma to anti-PD-1 immunotherapy by promoting ferroptosis.
Journal for immunotherapy of cancer
Guo W,Wu Z,Chen J,Guo S,You W,Wang S,Ma J,Wang H,Wang X,Wang H,Ma J,Yang Y,Tian Y,Shi Q,Gao T,Yi X,Li C
Wed Jun 01 00:00:00 EDT 2022
Anti-Inflammatory Effect of Dimethyl Fumarate Associates with the Inhibition of Thioredoxin Reductase 1 in RAW 264.7 Cells.
Molecules (Basel, Switzerland)
Yang R,Sun S,Guo Y,Meng Y,Liu H,Shi M,Guan S,Xu J
Fri Dec 23 00:00:00 EST 2022
The role of selenoproteins in neutrophils during inflammation.
Archives of biochemistry and biophysics
Lee TJ,Nettleford SK,McGlynn A,Carlson BA,Kirimanjeswara GS,Prabhu KS
Thu Dec 15 00:00:00 EST 2022
Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death.
International journal of molecular sciences
Szeliga M,Rola R
Sun Dec 11 00:00:00 EST 2022
Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation.
Experimental and therapeutic medicine
Zhang SP,Zhou J,Fan QZ,Lv XM,Wang T,Wang F,Chen Y,Hong SY,Liu XP,Xu BS,Hu L,Zhang C,Zhang YM
Sun Aug 01 00:00:00 EDT 2021
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.
The Journal of pharmacology and experimental therapeutics
Martinez R,Huang W,Samadani R,Mackowiak B,Centola G,Chen L,Conlon IL,Hom K,Kane MA,Fletcher S,Shapiro P
Fri Jan 01 00:00:00 EST 2021
Libertellenone H, a Natural Pimarane Diterpenoid, Inhibits Thioredoxin System and Induces ROS-Mediated Apoptosis in Human Pancreatic Cancer Cells.
Molecules (Basel, Switzerland)
Zhang W,Zhu Y,Yu H,Liu X,Jiao B,Lu X
Sat Jan 09 00:00:00 EST 2021
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Medical science monitor : international medical journal of experimental and clinical research
Yang M,Zhang W,Yu X,Wang F,Li Y,Zhang Y,Yang Y
Mon Jun 14 00:00:00 EDT 2021
Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway.
Frontiers in molecular biosciences
Jiao W,Bai M,Yin H,Liu J,Sun J,Su X,Zeng H,Wen J
Tue Sep 21 00:00:00 EDT 2021
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor.
Bioorganic chemistry
Fan QZ,Zhou J,Zhu YB,He LJ,Miao DD,Zhang SP,Liu XP,Zhang C
Tue Dec 01 00:00:00 EST 2020
Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor.
Bioorganic chemistry
Fan QZ,Zhou J,Zhu YB,He LJ,Miao DD,Zhang SP,Liu XP,Zhang C
Tue Dec 01 00:00:00 EST 2020
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Antioxidants (Basel, Switzerland)
Jasek-Gajda E,Jurkowska H,Jasińska M,Lis GJ
Fri Jul 17 00:00:00 EDT 2020
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Oxidative medicine and cellular longevity
Qi J,Chen X,Wu Q,Wang J,Zhang H,Mao A,Zhu M,Miao C
Tue Nov 17 00:00:00 EST 2020
A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-Ovarian-Cancer Agent by Inhibiting TrxR and Activating ROS-Mediated ERS.
Chemistry (Weinheim an der Bergstrasse, Germany)
Bian M,Sun Y,Liu Y,Xu Z,Fan R,Liu Z,Liu W
Tue Jun 02 00:00:00 EDT 2020
A Gold(I) Complex Containing an Oleanolic Acid Derivative as a Potential Anti-Ovarian-Cancer Agent by Inhibiting TrxR and Activating ROS-Mediated ERS.
Chemistry (Weinheim an der Bergstrasse, Germany)
Bian M,Sun Y,Liu Y,Xu Z,Fan R,Liu Z,Liu W
Tue Jun 02 00:00:00 EDT 2020
Synthesis and biological evaluation of myricetin-pentadienone hybrids as potential anti-inflammatory agents in vitro and in vivo.
Bioorganic chemistry
Liu C,Han X,Yu PJ,Chen LZ,Xue W,Liu XH
Sun Mar 01 00:00:00 EST 2020
The novel thioredoxin reductase inhibitor A-Z2 triggers intrinsic apoptosis and shows efficacy in the treatment of acute myeloid leukemia.
Free radical biology & medicine
Zhang D,Liu Y,Luo Z,Chen Y,Xu A,Liang Y,Wu B,Tong X,Liu X,Shen H,Liu L,Wei Y,Zhou H,Liu Y,Zhou F
Wed Jan 01 00:00:00 EST 2020
WHSC1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Activating mTORC1 Signaling.
OncoTargets and therapy
Dai J,Jiang L,Qiu L,Shao Y,Shi P,Li J
Sat Apr 16 00:00:00 EDT 2022
Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity.
European journal of medicinal chemistry
Bian M,Wang X,Sun Y,Liu W
Fri May 01 00:00:00 EDT 2020
Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity.
European journal of medicinal chemistry
Bian M,Wang X,Sun Y,Liu W
Fri May 01 00:00:00 EDT 2020
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
International journal of molecular sciences
Sparaneo A,Fabrizio FP,la Torre A,Graziano P,Di Maio M,Fontana A,Bisceglia M,Rossi A,Pizzolitto S,De Maglio G,Tancredi A,Grimaldi F,Balsamo T,Centra F,Manzorra MC,Trombetta D,Pantalone A,Bonfitto A,Maiello E,Fazio VM,Muscarella LA
Thu May 23 00:00:00 EDT 2019
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
International journal of molecular sciences
Sparaneo A,Fabrizio FP,la Torre A,Graziano P,Di Maio M,Fontana A,Bisceglia M,Rossi A,Pizzolitto S,De Maglio G,Tancredi A,Grimaldi F,Balsamo T,Centra F,Manzorra MC,Trombetta D,Pantalone A,Bonfitto A,Maiello E,Fazio VM,Muscarella LA
Thu May 23 00:00:00 EDT 2019
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
Biochemical pharmacology
Ye J,Ma J,Liu C,Huang J,Wang L,Zhong X
Thu Aug 01 00:00:00 EDT 2019
miR-125b-5p inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma via targeting TXNRD1.
Cancer cell international
Hua S,Quan Y,Zhan M,Liao H,Li Y,Lu L
Sat Apr 09 00:00:00 EDT 2022
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Oxidative medicine and cellular longevity
Maryam A,Mehmood T,Yan Q,Li Y,Khan M,Ma T
Tue Sep 18 00:00:00 EDT 2018
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Oxidative medicine and cellular longevity
Maryam A,Mehmood T,Yan Q,Li Y,Khan M,Ma T
Tue Sep 18 00:00:00 EDT 2018
Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.
Neurotoxicology
Liu D,Xue J,Liu Y,Gu H,Wei X,Ma W,Luo W,Ma L,Jia S,Dong N,Huang J,Wang Y,Yuan Z
Sat Dec 01 00:00:00 EST 2018
Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.
Neurotoxicology
Liu D,Xue J,Liu Y,Gu H,Wei X,Ma W,Luo W,Ma L,Jia S,Dong N,Huang J,Wang Y,Yuan Z
Sat Dec 01 00:00:00 EST 2018
Golgi stress mediates redox imbalance and ferroptosis in human cells.
Communications biology
Alborzinia H,Ignashkova TI,Dejure FR,Gendarme M,Theobald J,Wölfl S,Lindemann RK,Reiling JH
Wed Mar 04 00:00:00 EST 2020
Golgi stress mediates redox imbalance and ferroptosis in human cells.
Communications biology
Alborzinia H,Ignashkova TI,Dejure FR,Gendarme M,Theobald J,Wölfl S,Lindemann RK,Reiling JH
Wed Mar 04 00:00:00 EST 2020
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Redox biology
Zheng X,Ma W,Sun R,Yin H,Lin F,Liu Y,Xu W,Zeng H
Sun Apr 01 00:00:00 EDT 2018
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Redox biology
Zheng X,Ma W,Sun R,Yin H,Lin F,Liu Y,Xu W,Zeng H
Sun Apr 01 00:00:00 EDT 2018
Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity.
Redox biology
Zheng X,Ma W,Sun R,Yin H,Lin F,Liu Y,Xu W,Zeng H
Sun Apr 01 00:00:00 EDT 2018
Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Experimental and molecular pathology
Petersen DR,Orlicky DJ,Roede JR,Shearn CT
Wed Aug 01 00:00:00 EDT 2018
Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Experimental and molecular pathology
Petersen DR,Orlicky DJ,Roede JR,Shearn CT
Wed Aug 01 00:00:00 EDT 2018
Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
Biochemical and biophysical research communications
Hu X,Luo J,Lai H,Li M,Zheng X,Nie T,Li F,Li H
Wed Sep 05 00:00:00 EDT 2018
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Journal of Cancer
Mehmood T,Maryam A,Tian X,Khan M,Ma T
Wed Mar 30 00:00:00 EDT 2022
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Journal of Cancer
Mehmood T,Maryam A,Tian X,Khan M,Ma T
Wed Mar 30 00:00:00 EDT 2022
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Redox biology
Chen X,Zhao X,Cai H,Sun H,Hu Y,Huang X,Kong W,Kong W
Tue Aug 01 00:00:00 EDT 2017
The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways.
Redox biology
Chen X,Zhao X,Cai H,Sun H,Hu Y,Huang X,Kong W,Kong W
Tue Aug 01 00:00:00 EDT 2017
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
Scientific reports
Maryam A,Mehmood T,Zhang H,Li Y,Khan M,Ma T
Mon Jul 24 00:00:00 EDT 2017
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
Scientific reports
Maryam A,Mehmood T,Zhang H,Li Y,Khan M,Ma T
Mon Jul 24 00:00:00 EDT 2017
Ruthenium(II) Complexes with 2-Phenylimidazo[4,5-f][1,10]phenanthroline Derivatives that Strongly Combat Cisplatin-Resistant Tumor Cells.
Scientific reports
Zeng L,Chen Y,Liu J,Huang H,Guan R,Ji L,Chao H
Thu Jan 14 00:00:00 EST 2016
Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function.
Cancer research
Bera S,Weinberg F,Ekoue DN,Ansenberger-Fricano K,Mao M,Bonini MG,Diamond AM
Mon Sep 15 00:00:00 EDT 2014
Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function.
Cancer research
Bera S,Weinberg F,Ekoue DN,Ansenberger-Fricano K,Mao M,Bonini MG,Diamond AM
Mon Sep 15 00:00:00 EDT 2014
Translational regulation of GPx-1 and GPx-4 by the mTOR pathway.
PloS one
Reinke EN,Ekoue DN,Bera S,Mahmud N,Diamond AM
Thu Dec 17 00:00:00 EST 2015
Translational regulation of GPx-1 and GPx-4 by the mTOR pathway.
PloS one
Reinke EN,Ekoue DN,Bera S,Mahmud N,Diamond AM
Thu Dec 17 00:00:00 EST 2015
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Longevity & healthspan
Brown-Borg HM,Rakoczy S,Wonderlich JA,Armstrong V,Rojanathammanee L
Tue Jan 13 00:00:00 EST 2015
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Longevity & healthspan
Brown-Borg HM,Rakoczy S,Wonderlich JA,Armstrong V,Rojanathammanee L
Tue Jan 13 00:00:00 EST 2015
Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue.
Oral oncology
Zhu X,Huang C,Peng B
Fri Jul 01 00:00:00 EDT 2011
Overexpression of thioredoxin system proteins predicts poor prognosis in patients with squamous cell carcinoma of the tongue.
Oral oncology
Zhu X,Huang C,Peng B
Fri Jul 01 00:00:00 EDT 2011
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Oncology reports
Iwasawa S,Yamano Y,Takiguchi Y,Tanzawa H,Tatsumi K,Uzawa K
Tue Mar 01 00:00:00 EST 2011
Upregulation of thioredoxin reductase 1 in human oral squamous cell carcinoma.
Oncology reports
Iwasawa S,Yamano Y,Takiguchi Y,Tanzawa H,Tatsumi K,Uzawa K
Tue Mar 01 00:00:00 EST 2011
Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression.
Nucleic acids research
Miniard AC,Middleton LM,Budiman ME,Gerber CA,Driscoll DM
Sun Aug 01 00:00:00 EDT 2010
Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression.
Nucleic acids research
Miniard AC,Middleton LM,Budiman ME,Gerber CA,Driscoll DM
Sun Aug 01 00:00:00 EDT 2010
