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Product Details
CF801551
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI10F12
Immunogen
Full length human recombinant protein of human TYMS produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC88736; Thymidylate synthase; TS; TSase; tysy
Gene Aliases: HST422; OK/SW-cl.29; TMS; TS; TYMS
UniProt ID: (Human) P04818
Entrez Gene ID: (Human) 7298
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
nucleobase-containing compound metabolic process
dTMP biosynthetic process
dTTP biosynthetic process
aging
circadian rhythm
cell proliferation
deoxyribonucleoside monophosphate biosynthetic process
response to toxic substance
cell growth
immortalization of host cell by virus
uracil metabolic process
organ regeneration
methylation
response to progesterone
response to vitamin A
response to cytokine
tetrahydrofolate interconversion
response to drug
response to ethanol
dUMP metabolic process
pyrimidine nucleoside biosynthetic process
response to organophosphorus
developmental growth
cartilage development
response to glucocorticoid
response to folic acid
intestinal epithelial cell maturation
DNA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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