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Invitrogen
TYRP1 Chimeric Recombinant Rabbit Monoclonal Antibody (TA99)
FIGURE: 1 / 1
TYRP1 Chimeric Antibody (MA5-47827) in Flow
Flow Cytometry analysis of TYRP1 in Mouse splenocytes (A), B16F10 murine melanoma cells (B), KPC3 pancreas carcinoma cells (C) and KPC3 cells transfected with the Trp1 gene (D) using TYRP1 Chimeric Monoclonal Antibody (Product # MA5-47827). Cells were fixed using 2% PFA, permeabilized using 0.5% Triton and were subject to a primary treatment of either buffer, mouse-IgG1 chimeric 2C11 or mouse-IgG1 chimeric TA99 (indicated above plots) before a secondary treatment with buffer, goat anti-mouse Ig-allophycocyanin (G-aM Ig-APC) or anti-His Tag... View More
Product Details
MA5-47827
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
TA99
Immunogen
70-75 kDa pigmentation-associated glycoprotein in human melanoma cell lines.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3074274
Product Specific Information
Specificity: Binds Tyrosinase-related protein-1 (TRP-1), a 70-75k enzyme located in melanocytes, which are specialized cells that produce a pigment called melanin, helping to stabilize tyrosinase, which is the enzyme responsible for the first step in melanin production and determine the shape of melanosomes, which are the structures in melanocytes where melanin is produced.
Target Information
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; DHICA oxidase; Glycoprotein 75; Melanoma antigen gp75; MGC120175; MGC149362; RP11-3L8.1; TRP; TRY1; TRY4; TRYP1; Tyrosinase-related protein 1
Gene Aliases: b-PROTEIN; CAS2; CATB; GP75; OCA3; TRP; TRP1; TYRP; TYRP1; TYRRP
UniProt ID: (Human) P17643
Entrez Gene ID: (Human) 7306
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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