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NeoBiotechnologies
Tenascin C (Stromal Marker for Epithelial Malignancy) Monoclonal Antibody (TNC/4806)
Product Details
3371-MSM6-P1ABX
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2c, kappa
Class
Monoclonal
Type
Antibody
Clone
TNC/4806
Immunogen
Recombinant human full-length TNC protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
Positive Control: and lung carcinomas. Staining of normal fibroblasts serves as internal positive control (IHC). Extracellular matrix in tonsil and blood vessels. Stroma of many tumors such as breast squamous cell
Cellular Location: Connective tissue matrix
Target Information
Tenascin is a high molecular weight, multifunctional, extracellular matrix glycoprotein expressed in association with mesenchymal-epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors (Erickson and Bourdon 1989). It has been described under a variety of names: cytotactin, hexabrachion protein, J1, myotendinous antigen (MI) and glioma mesenchymal extracellular matrix (GMEM). The tenascin molecule is a disulfide-linked hexamer. The expression of tenascin is associated with development and growth, both normal and pathological, whereas the distribution in normal adult tissue is restricted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytotactin; deafness, autosomal dominant 56; Glioma-associated-extracellular matrix antigen; GMEM; GP 150-225; Hexabrachion; hexabrachion (tenascin); JI; MGC144208; MGC144209; MGC167029; Myotendinous antigen; Neuronectin; Tenascin; Tenascin-C; tenascin-C additional domain 1; tenascin-C isoform 14/AD1/16; TN; TN-C
Gene Aliases: 150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C; TNC
UniProt ID: (Human) P24821
Entrez Gene ID: (Human) 3371
osteoblast differentiation
cell adhesion
negative regulation of cell adhesion
neuromuscular junction development
positive regulation of cell proliferation
response to wounding
response to mechanical stimulus
positive regulation of gene expression
peripheral nervous system axon regeneration
extracellular matrix organization
wound healing
odontogenesis of dentin-containing tooth
response to ethanol
bud outgrowth involved in lung branching
mesenchymal-epithelial cell signaling involved in prostate gland development
prostate gland epithelium morphogenesis
cellular response to retinoic acid
cellular response to vitamin D
response to fibroblast growth factor
cellular response to prostaglandin D stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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