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Thrombomodulin Polyclonal Antibody

Thrombomodulin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Thrombomodulin Antibody (14318-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart tissue slide using 14318-1-AP ( Thrombomodulin antibody at dilution of 1:200 (under 40x lens).

Thrombomodulin Antibody in Western Blot (WB)

Thrombomodulin Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

14318-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Thrombomodulin Fusion Protein Ag5558 (18-350 aa encoded by BC035602)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PAPAEPQPG GSQCVEHDCF ALYPGPATFL NASQICDGLR GHLMTVRSSV AADVISLLLN GDGGVGRRRL WIGLQLPPGC GDPKRLGPLR GFQWVTGDNN TSYSRWARLD LNGAPLCGPL CVAVSAAEAT VPSEPIWEEQ QCEVKADGFL CEFHFPATCR PLAVEPGAAA AAVSITYGTP FAARGADFQA LPVGSSAAVA PLGLQLMCTA PPGAVQGHWA REAPGAWDCS VENGGCEHAC NAIPGAPRCQ CPAGAALQAD GRSCTASATQ SCNDLCEHFC VPNPDQPGSY SCMCETGYRL AADQHRCEDV DDCILEPSPC PQRCVNTQGG FECH (18-350 aa encoded by BC035602)

Target Information

Thrombomodulin (TM) is also known as Fetomodulin (FM), endothelial anticoagulant protein, or glycoprotein P112. Thrombomodulin contains six repeated domains homologous with epidermal growth factor (EGF) and an amino terminal domain homologous to lectin-like protein. Through its accelerated activation of protein C, synthesis of TM is one of several mechanisms important in maintaining thrombo-resistance and thus reducing clot formation on the surface of the endothelial cells. Immunohistochemical staining of formalin-fixed tissue for TM has been used for the study of a variety of vascular tumors, meningiomas and choriocarcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The effect and mechanism of excessive iodine on the endothelial function of human umbilical vein endothelial cells.

Environmental toxicology

Wang D,Li P,Liu L,Liu P,Zhou Z,Jin M,Li B,Li F,Chen Y,Shen H

Sun Jan 01 00:00:00 EST 2023

The crescendo pulse frequency of shear stress stimulates the endothelialization of bone marrow mesenchymal stem cells on the luminal surface of decellularized scaffold in the bioreactor.

Bioengineered

Jiao Y,Zhang Y,Xiao Y,Xing Y,Cai Z,Wang C,Zhou Z,Feng Z,Gu Y

Tue Mar 01 00:00:00 EST 2022

Urinary SARS-CoV-2 RNA is An Indicator For The Progression and Prognosis of COVID-19 Disease.

Research square

Tian M,Zhang L,Zhu K,Shen B,Wang G,Song Y,Chen C,Liang W,Guan Y,Ding G,Lei T,Li X,Xie J,Tong Y,Wang H

Thu Feb 18 00:00:00 EST 2021

Urinary SARS-CoV-2 RNA Is an Indicator for the Progression and Prognosis of COVID-19.

Diagnostics (Basel, Switzerland)

Zhang L,Tian M,Song Y,Liang W,Li X,Tong Y,Wang H

Fri Nov 12 00:00:00 EST 2021

Crocin Improves Endothelial Mitochondrial Dysfunction via GPx1/ROS/KCa3.1 Signal Axis in Diabetes.

Frontiers in cell and developmental biology

Li X,Liu Y,Cao A,Li C,Wang L,Wu Q,Li X,Lv X,Zhu J,Chun H,Laba C,Du X,Zhang Y,Yang H

Tue Mar 30 00:00:00 EDT 2021

The histone methyltransferase SETD1A regulates thrombomodulin transcription in vascular endothelial cells.

Biochimica et biophysica acta. Gene regulatory mechanisms

Li Z,Chen B,Weng X,Yu L,Song M,Fang M,Guo J,Xu Y

Wed Aug 01 00:00:00 EDT 2018

The histone methyltransferase SETD1A regulates thrombomodulin transcription in vascular endothelial cells.

Biochimica et biophysica acta. Gene regulatory mechanisms

Li Z,Chen B,Weng X,Yu L,Song M,Fang M,Guo J,Xu Y

Wed Aug 01 00:00:00 EDT 2018

Endocardial Changes in Nonvalvular Atrial Fibrillation Without Atrial Thrombus-Thrombomodulin and Tissue Factor Pathway Inhibitor.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

An K,Mei J,Zhu J,Tang M

Mon Oct 01 00:00:00 EDT 2018

Endocardial Changes in Nonvalvular Atrial Fibrillation Without Atrial Thrombus-Thrombomodulin and Tissue Factor Pathway Inhibitor.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

An K,Mei J,Zhu J,Tang M

Mon Oct 01 00:00:00 EDT 2018

Atrial endocardial expression of von Willebrand factor and thrombomodulin is associated with recurrence after minimally invasive surgical atrial fibrillation ablation.

Interactive cardiovascular and thoracic surgery

An K,Yin H,Mei J,Zhu J,Tang M

Wed Aug 01 00:00:00 EDT 2018

Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor-23/α-Klotho.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

Tanaka K,Salunya T,Motomiya Y,Motomiya Y,Oyama Y,Yamakuchi M,Maruyama I

Tue Aug 01 00:00:00 EDT 2017

Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor-23/α-Klotho.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

Tanaka K,Salunya T,Motomiya Y,Motomiya Y,Oyama Y,Yamakuchi M,Maruyama I

Tue Aug 01 00:00:00 EDT 2017

Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor-23/α-Klotho.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

Tanaka K,Salunya T,Motomiya Y,Motomiya Y,Oyama Y,Yamakuchi M,Maruyama I

Tue Aug 01 00:00:00 EDT 2017

Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor-23/α-Klotho.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

Tanaka K,Salunya T,Motomiya Y,Motomiya Y,Oyama Y,Yamakuchi M,Maruyama I

Tue Aug 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: BDCA-3; CD141; CD141 antigen; DC141; Fetomodulin; sCD141; soluble CD141; Thrombomodulin; TM

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Gene Aliases: AHUS6; BDCA3; CD141; THBD; THPH12; THRM; TM

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UniProt ID: (Human) P07204

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Entrez Gene ID: (Human) 7056

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Function(s)

receptor activity transmembrane signaling receptor activity calcium ion binding protein binding transmembrane signal receptor

Process(es)

signal transduction female pregnancy blood coagulation response to X-ray negative regulation of platelet activation negative regulation of blood coagulation response to lipopolysaccharide leukocyte migration response to cAMP negative regulation of fibrinolysis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Thrombomodulin Polyclonal Antibody

Thrombomodulin Antibody (14318-1-AP) in IHC (P)

Product Details

14318-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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